The Dow advanced to close sharply higher with the blue chip index surging 118 points to 24,504 on strong gains in producer prices. Nasdaq lost 12 points to 6,862.
On the upside
Proteostasis Therapeutics (Nasdaq: PTI) reported positive results from three studies, PTI-428, PTI-801 and PTI-808 to treat cystic fibrosis.
GlycoMimetics (Nasdaq: GLYC) reported upbeat updated data from the Phase 1/2 trial for GMI-1271 to treat relapsed/refractory acute myeloid leukemia.
Bargain hunters lifted shares of Syros Pharmaceuticals (Nasdaq: SYRS).
On the downside
Two of seven patients in Global Blood Therapeutics (Nasdaq: GBT) study of voxelotor died.
Kosmos Energy (NYSE: KOS) will plug its Lamantin-1 exploration well offshore Mauritania.
Casey's General Stores (Nasdaq: CASY) reported lower second quarter earnings.
In the broad market, declining issues outpaced advancers by a margin of 6 to 5 on the NYSE and by 5 to 4 on Nasdaq. The broader S&P 500 rose 4 points to 2,664. Bitcoin soared $321 to $17,113.