The markets opened lower with the Dow dropping 79 points to 17,925 as crude oil prices retreated. Nasdaq fell 21 points to 4,953.

On the upside

Jaguar Animal Health (Nasdaq: JAGX) entered a $15 million common stock purchase agreement and a registration rights agreement with Aspire Capital Fund.

Staffing 360 Solutions (Nasdaq: STAF) reported higher preliminary full year and fourth quarter revenue.

Great Basin Scientific (Nasdaq: GBSN) will exhibit its diagnostic platform at the ASM Microbe 2016.

On the downside

Restoration Hardware (NYSE: RH) fell to a greater than expected loss of the first quarter, forecast current quarter earnings below estimates and cut its full year guidance.

Tailored Brands (NYSE: TLRD) disappointed with sharply lower first quarter results that missed estimates.

Profit taking sank shares of Biostar Pharmaceuticals (Nasdaq: BSPM).

In the broad market, declining issues outpaced advancers by a margin of 3 to 1 on the NYSE and by more than 5 to 2 on Nasdaq. The broader S&P 500 fell 9 points to 2,110. Bitcoin fell $5 to $569.