The markets opened lower with the Dow slipping 4 points to 17,732 on disappointing initial public offerings from two technology companies. Nasdaq eased a fraction to 5,074.

On the upside

Turing Pharmaceuticals chief executive Martin Shkreli bought more than 50% of KaloBios Pharmaceuticals (Nasdaq: KBIO) stock.

Celladon (Nasdaq: CLDN) will merge with Eiger BioPharmaceuticals.

Keurig Green Mountain (Nasdaq: GMCR) reported a greater than expected profit for the fourth quarter.

On the downside

Falling crude oil prices weighed down shares of Chesapeake Energy (NYSE: CHK).

Kirkland’s (Nasdaq: KIRK) fell to an unexpected loss for the third quarter, forecast current quarter results below estimates and lowered its full year earnings outlook.

JinkoSolar Holding (NYSE: JKS) reported lower third quarter earnings even as revenue soared.

In the broad market, advancing issues barely edged out decliners by a slim margin on the NYSE while decliners outpaced advancers more than 10 to 9 on Nasdaq. The broader S&P 500 eased a fraction to 2,082. Bitcoin fell $8 to $325.