Retreating crude oil prices weighed the markets down to a lower close with the Dow losing 49 points to 17,081. Nasdaq tumbled 42 points to 4,796.

On the upside

Fortress Investment Group (NYSE: FIG) will close the Fortress Macro Fund after disappointing performance this year.

Shares of Genocea Biosciences (Nasdaq: GNCA) extended its gains.

Deerfield Management acquired a 9.97% stake in XenoPort (Nasdaq: XNPT).

On the downside

Investors locked in profits on Heron Therapeutics (Nasdaq: HRTX).

MiMedx Group (Nasdaq: MDXG) reported sharply higher third quarter revenue but the stock price fell after the company established a credit facility.

Intrexon (NYSE: XON) subsidiary ViaGen Pets successfully delivered two litters of healthy, cloned kittens for clients but the stock price plunged.

In the broad market, declining issues outpaced advancers by a margin of more than 5 to 2 on both the NYSE and on Nasdaq. The broader S&P 500 dropped 13 points to 2,003. Bitcoin rose $3 to $247.