The markets opened mixed with the Dow slipping 5 points to 13,192 while Nasdaq added 3 points to 3123 as durable goods orders rose less than expected in February.

On the upside

Bloomberg reported that Amylin Pharmaceuticals (Nasdaq: AMLN) rejected a $3.5 billion acquisition offer from Bristol-Myers Squibb (NYSE: BMY).

The U. S. Patent and Trademark Office granted Vermillion (Nasdaq: VRML) a patent for the use of Protein C Inhibitor in ovarian cancer tests.

Pentair (NYSE: PNR) will merge with Tyco International’s (NYSE: TYC) flow control business.

On the downside

Investors locked in profits on Arena Pharmaceuticals (Nasdaq: ARNA), whose stock price climbed the last two days after announcing that European regulators accepted the marketing application for its weight loss treatment Lorcaserin.   

Shares of Alpha Natural Resources (NYSE: ANR), Arch Coal (NYSE: ACI) and Patriot Coal (NYSE: PCX) all fell after the Environmental Protection Agency proposed yesterday to limit carbon emissions. 

Profit taking sank shares of Affymax (Nasdaq: AFFY).

In the broad market, declining issues outpaced advancers by a margin of more than 10 to 9 on the NYSE while advancers were on par with decliners on Nasdaq. The Russell 2000 which tracks small cap stocks held steady at 839.