A shooting at Canada’s parliament building sent the markets tumbling to a sharply lower close with the Dow plummeting 153 points to 16,461. Nasdaq dropped 36 points to 4,382.

On the upside

NewLink Genetics (Nasdaq: NLNK) chief executive Charles Link said that an Ebola vaccine could be ready by the end of the year.

Super Micro Computer (Nasdaq: SMCI) reported higher first quarter earnings and revenue that surpassed analyst expectations. 

Third quarter earnings and revenue climbed Gentex (Nasdaq: GNTX) to top estimates.

On the downside

Investors locked in profits on Forest Oil (NYSE: FST).

BMO Capital Markets downgraded Coeur Mining (NYSE: CDE) from a Market Perform rating to an Underperform rating.

Tupperware Brands (NYSE: TUP) reported lower third quarter earnings that missed estimates.

In the broad market, declining issues outpaced advancers by a margin of nearly 7 to 3 on the NYSE and by nearly 3 to 1 on Nasdaq. The broader S&P 500 tumbled 14 points to 1927. Bitcoin slipped $2 to $380.