Crude oil prices fell to a five-year low sending the markets plunging to a sharply lower close with the Dow plummeting 106 points to 17,852. Nasdaq tumbled 40 points to 4,740.

On the upside

Merck’s (NYSE: MRK) acquisition of Cubist Pharmaceuticals (Nasdaq: CBST) lifted shares of fellow antibiotic developer Cempra (Nasdaq: CEMP).

Investor interest in CAR-T cancer immunotherapy lifted shares of Bluebird Bio (Nasdaq: BLUE) and Celgene (Nasdaq: CELG), which partnered to develop CAR-T therapies through a joint venture.

Norbord’s acquisition of Ainsworth Lumber lifted shares of building products manufacturer Louisiana-Pacific (NYSE: LPX).

On the downside

Goodrich Petroleum (NYSE: GDP), Sanchez Energy (NYSE: SN) and Mill Energy Resources (NYSE: MILL) as fell as crude oil prices dropped to its lowest level in five years.

Oilfield services provider Seventy Seven Energy (NYSE: SSE) tumbled.

Shares of oil and gas engineering firm McDermott International (NYSE: MDR) dropped.

In the broad market, declining issues outpaced advancers by a margin of nearly 5 to 2 on the NYSE and by nearly 3 to 1 on Nasdaq. The broader S&P 500 dropped 15 points to 2060. Bitcoin lost $8 to $363.