Quantum-Si demonstrates a path to enable >70% coverage of the human proteome and the identification of up to 90% of proteins, including post-translational modifications

Company continues to advance the core technology as it progresses towards commercialization of its Platinum™ Protein Sequencing Platform later this year

Jun. 1, 2022 -- Quantum-Si Incorporated (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Company”), a life sciences company commercializing single molecule protein sequencing, announced that Brian Reed, Ph.D., Head of Research at Quantum-Si, presented an update on the Company’s technology advancements at the Next-Generation Protein Analysis and Detection Conference, a VIB Tools & Technologies conference, in Ghent, Belgium. The presentation is available on the Investors section of the Quantum-Si website under Events & Presentations.

Dr. Reed discussed Quantum-Si’s research and development progress, including the expansion of the technology to interrogate more of the human proteome and its estimated 1,000,000+ proteoforms. This is essential for researchers to gain insights into how protein changes impact disease states. Reed also provided an overview of Quantum-Si’s protein sequencing technology platform, including Platinum™, which uses a proprietary and novel approach called Time Domain Sequencing™ to precisely decode the order of amino acids in a protein and interrogate changes for the identification of new drug targets and diagnostic biomarkers. The ability to directly sequence proteins from a variety of sample types will generate new applications across disciplines such as oncology, neurology and cardiology.

“We have invested heavily in protein engineering and directed evolution approaches to accelerate the development of amino acid recognizers and increase the proportion of the proteome that we can detect,” said Reed. “To date, we have made significant progress towards commercial launch, having now demonstrated successful on-chip recognition of 15 out of 20 amino acids. These 15 amino acids represent a path to more than 70% coverage of the human proteome, identification of up to 90% of proteins, as well as a greater understanding of protein sequence variation and post-translational modifications. Future developments of the platform will increase the accessibility of proteomics studies and enable new discoveries in biological and clinical research.”

To learn more about Quantum-Si’s technology, download the Company’s latest whitepaper, titled “Digitizing Protein Sequencing: Detecting Individual Amino Acids through Real-Time Photon Emission,” here.

About Quantum-Si Incorporated

Quantum-Si is focused on revolutionizing the growing field of proteomics. The Company's suite of technologies is powered by a first-of-its-kind semiconductor chip designed to enable single molecule next-generation protein sequencing and digitize proteomic research in order to advance drug discovery and diagnostics beyond what has been possible with DNA sequencing. Learn more at www.quantum-si.com.

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