Filed Pursuant to Rule 424(b)(3)
                                                     Registration No. 333-110858


                              PROSPECTUS SUPPLEMENT
                                    Number 1
                                       to

                       Prospectus dated December 18, 2003

                                       of

                              NEOPROBE CORPORATION

                        21,817,257 SHARES OF COMMON STOCK

This Prospectus Supplement relates to the sale of up to 21,817,257 shares of
Neoprobe Corporation common stock (the "Shares"). The Shares are being
registered to permit public secondary trading of the shares that are being
offered by the selling shareholders named in the prospectus. We are not selling
any of the Shares in this offering and therefore will not receive any proceeds
from this offering.

This Prospectus Supplement No. 1 includes the attached Annual Report on Form
10-KSB (the "Form 10-KSB") of Neoprobe Corporation (the "Company"), for the year
ended December 31, 2003, filed by the Company with the Securities and Exchange
Commission on March 30, 2004. The exhibits to the Form 10-KSB are not included
with this Prospectus Supplement No. 1 and are not incorporated by reference
herein.

Our common stock is traded on the Over-the-Counter Bulletin Board under the
symbol "NEOP".

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS SUPPLEMENT. ANY REPRESENTATION TO THE
CONTRARY IS A CRIMINAL OFFENSE.



         The date of this Prospectus Supplement No. 1 is March 30, 2004.