As filed with the Securities and Exchange Commission on October 10, 2003
                                                     REGISTRATION NO. 333-106988
================================================================================
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                ----------------

                                    FORM S-3
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                                ----------------

                           ESPERION THERAPEUTICS, INC.
             (Exact name of registrant as specified in its charter)

                                ----------------


           DELAWARE              3621 SOUTH STATE STREET        38-3419139
(State or other jurisdiction          695 KMS PLACE          (I.R.S. Employer
of incorporation or organization)  ANN ARBOR, MICHIGAN    Identification Number)
                                          48108
                                     (734) 332-0506


  (Address, including zip code, and telephone number, including area code, of
                   registrant's principal executive offices)

                                ----------------


                             ROGER S. NEWTON, PH.D.
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                           ESPERION THERAPEUTICS, INC.
                             3621 SOUTH STATE STREET
                                  695 KMS PLACE
                            ANN ARBOR, MICHIGAN 48108
                                 (734) 332-0506
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)

                                ----------------

                                   COPIES TO:
                              LINDA L. GRIGGS, ESQ.
                           MORGAN, LEWIS & BOCKIUS LLP
                         1111 PENNSYLVANIA AVENUE, N.W.,
                             WASHINGTON, D.C. 20004
                                 (202) 739-3000

      APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon
as practicable after this Registration Statement becomes effective.






         If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. [ ]

         If any of the securities being registered on this Form are to be
offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933, other than securities offered only in connection with
dividend or interest reinvestment plans check the following box. [X]

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [ ]

         If this Form is a post-effective amendment filed pursuant to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act registration statement number of the earlier registration statement for the
same offering. [ ]

         If delivery of the prospectus is expected to be made pursuant to Rule
434, please check the following box. [ ]


                         CALCULATION OF REGISTRATION FEE




                                                                PROPOSED            PROPOSED
                                              AMOUNT TO          MAXIMUM             MAXIMUM          AMOUNT OF
                                                 BE           OFFERING PRICE        AGGREGATE        REGISTRATION
TITLE OF EACH CLASS OF SECURITIES TO BE       REGISTERED        PER SHARE         OFFERING PRICE         FEE
             REGISTERED
                                                                                         
Common Stock, par value $.001 per share        25,000             19.60             $490,000           $39.64




(1)      The proposed maximum aggregate offering price, estimated solely for the
         purpose of calculating the registration fee, has been computed pursuant
         to Rule 457(h) promulgated under the Securities Act of 1933 and is
         based on the average of the high and low prices of Esperion
         Therapeutics, Inc.'s common stock, par value $.001 per share on October
         9, 2003, as reported by The Nasdaq National Market.

         THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE
OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT
SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THIS REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION, ACTING
PURSUANT TO SECTION 8(A), MAY DETERMINE.






         THE INFORMATION IN THIS PROSPECTUS IS NOT COMPLETE AND MAY BE CHANGED.
WE MAY NOT SELL THESE SECURITIES UNTIL THE REGISTRATION STATEMENT FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION IS EFFECTIVE. THIS PROSPECTUS IS NOT AN OFFER
TO SELL THESE SECURITIES AND IT IS NOT SOLICITING AN OFFER TO BUY THESE
SECURITIES IN ANY JURISDICTION WHERE THE OFFER OR SALE IS NOT PERMITTED.

                 SUBJECT TO COMPLETION, DATED OCTOBER 10, 2003

                                   PROSPECTUS

                          25,000 SHARES OF COMMON STOCK

                                 [COMPANY LOGO]

         This prospectus relates to an offering by Franklin Templeton Bank &
Trust, F.S.B. (the "Selling Stockholder"), as trustee of the Esperion
Therapeutics, Inc. 401(k) Savings Plan (the "Plan"), of up to 25,000 shares (the
"Shares") of common stock, par value $.001 per share (the "Common Stock"), of
Esperion Therapeutics, Inc., a Delaware corporation (the "Company").

         Our common stock is traded on The Nasdaq National Market under the
symbol "ESPR."

         An investment in our common stock involves risks. For a discussion of
certain factors that should be considered in evaluating an investment in the
Shares, see "Risk Factors," beginning on page 4.

         We will not receive any part of the proceeds from the sale of the
Shares by the Selling Stockholder. We have agreed to bear all of the expenses
incurred in connection with the registration of the Shares. The Selling
Stockholder will pay its own expenses, including any brokerage commissions,
personal legal fees or similar expenses relating to the offer and the sale of
the Shares.

         NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

                The date of this prospectus is October ____, 2003







                                TABLE OF CONTENTS




PROSPECTUS SUMMARY......................................1
RISK FACTORS............................................4
FORWARD-LOOKING STATEMENTS..............................16
USE OF PROCEEDS.........................................17
SELLING STOCKHOLDER.....................................18
PLAN OF DISTRIBUTION....................................18
WHERE YOU CAN FIND MORE INFORMATION.....................19
DOCUMENTS INCORPORATED BY REFERENCE.....................19
EXPERTS.................................................20








                                       i


                               PROSPECTUS SUMMARY

         This summary highlights information contained elsewhere in this
prospectus. You should read the following summary together with the more
detailed information regarding our company, our common stock and the financial
statements and notes to those statements incorporated herein by reference from
our other filings with the Securities and Exchange Commission (the "SEC"). We
urge you to read the entire prospectus carefully, especially the risks of
investing in our common stock, which are discussed under "Risk Factors," before
making an investment decision.

                           ESPERION THERAPEUTICS, INC.

         Esperion Therapeutics, Inc. is a biopharmaceutical company dedicated to
the discovery, development and commercialization of therapies to improve the
treatment of cardiovascular disease. Our initial focus is on the development and
commercialization of novel classes of drugs that focus on a new treatment
approach based upon our understanding of high density lipoprotein, or HDL,
function. We call this approach "HDL Therapy." By exploiting the beneficial
properties of HDL, or "good cholesterol," to remove excess cholesterol and other
lipids from artery walls and other tissues, we believe our portfolio of product
candidates offers an innovative approach in the fight against cardiovascular
disease. While current therapies are designed to slow the progression of
cardiovascular disease, we believe "HDL Therapy" has the potential to reverse
the damaging effects of cholesterol deposits within artery walls.

         We currently have four product candidates in clinical development,
including three biopharmaceuticals: ETC-588, or LUV; ETC-216, or AIM; and
ETC-642, or RLT Peptide; and one oral small molecule, ETC-1001, each targeted at
cardiovascular disease or its risk factors. Our biopharmaceuticals are being
developed to focus on the acute treatment of high-risk atherosclerosis, such as
acute coronary syndromes, while our oral small molecule targets chronic
treatment of risk factors associated with cardiovascular disease.

         We are also pursuing the discovery and development of orally active
organic small molecules designed to increase HDL-cholesterol, or HDL-C, levels
and enhance the function of HDL and to decrease low density
lipoprotein-cholesterol, LDL-C, or "bad cholesterol," levels and triglycerides,
another type of lipid, or fat. We believe some of these oral small molecules may
possess anti-diabetic and anti-obesity properties.

         We believe our product candidates will enhance the naturally occurring
processes in the body for the removal of excess cholesterol and other lipids
from artery walls and other tissues by enhancing the efficiency of the reverse
lipid transport, or RLT, pathway. The RLT pathway is a four-step process through
which excess cholesterol and other lipids are removed from artery walls and
other tissues. We believe this removal of excess cholesterol and other lipids
from artery walls and other tissues will lead to improvements in vascular
structure by stabilizing vulnerable plaque, which could ultimately lead to a
reduction in clinical events resulting from cardiovascular disease, including
atherosclerosis.

         Results of clinical trials and pre-clinical studies indicate that
ETC-588, ETC-216 and ETC-642 demonstrate mobilization of cholesterol, which is
the removal of excess cholesterol from artery walls and other tissues, as
evidenced by measurements of the amount of cholesterol and other lipids in the
blood before and after administration. The current clinical development status
of our product candidates is as follows:

         o        ETC-588 (PHASE II): Enrollment in one of our two ongoing Phase
                  II studies was completed in July 2003. The objective of this
                  study is to evaluate the safety and tolerability of ETC-588 in



1


                  approximately 150 patients with acute coronary syndromes.
                  Enrollment in the second of the ongoing Phase II clinical
                  trials for ETC-588 was completed in September 2003. This Phase
                  II trial uses magnetic resonance imaging (MRI) technology to
                  examine the effect, if any, of ETC-588 on plaque in the
                  carotid arteries and whether the benefits of therapy persist
                  three months after completion of treatment.

         o        ETC-216 (PHASE II): In June 2003, we reported initial results
                  that showed that our multiple-dose, multi-center Phase II
                  clinical study met its primary efficacy objective of
                  demonstrating statistically significant regression of
                  atherosclerosis with ETC-216. The trial was a double-blind,
                  placebo-controlled study evaluating the efficacy of ETC-216 at
                  two different dose levels (15 mg/kg and 45 mg/kg),
                  administered once weekly for a maximum of five treatments. The
                  study included 47 evaluable patients with acute coronary
                  syndromes who were scheduled to undergo coronary angiography
                  and who continued to receive their current treatments during
                  the study. Changes in plaque volume were measured using
                  intravascular ultrasound, in which a tiny ultrasound probe is
                  inserted into the coronary artery to directly image
                  atherosclerotic plaques. The primary endpoint was the change
                  in percent plaque volume for all evaluable patients receiving
                  ETC-216 comparing end-of-treatment values to baseline values
                  as measured with intravascular ultrasound. The results of this
                  study demonstrated, for the first time in a clinical trial,
                  statistically significant regression of atherosclerosis at the
                  end of six weeks.

         o        ETC-642 (PHASE I): In June 2003, we initiated our first
                  multiple-dose, multi-center clinical trial in up to 32
                  patients with stable cardiovascular disease. The primary
                  objective of this study is to assess potential dosing levels
                  and regimens for ETC-642 while evaluating safety and
                  tolerability. In 2002, a Phase I single escalating dose
                  clinical trial for ETC-642 was initiated in patients with
                  stable cardiovascular disease. Enrollment in this study was
                  completed in August 2003. The objective of this study is to
                  determine the maximum tolerated dose.

         o        ETC-1001 (PHASE I): We recently completed enrollment in our
                  first clinical trial for ETC-1001 in healthy volunteers. This
                  trial is a double-blind, placebo-controlled trial designed to
                  evaluate the safety and tolerability of single escalating
                  doses of ETC-1001.

         We believe our drug discovery technology and scientific and drug
development expertise have potential applicability to the discovery and
development of therapies for a broad range of vascular diseases, including
treatments for coronary heart disease, peripheral arterial disease
(atherosclerosis occurring in arteries near the body's extremities) and stroke.


         In August 2003, we completed a public offering of 4,434,000 shares of
our common stock, raising net proceeds of approximately $66.8 million. We
currently intend to use the net proceeds from that offering to fund our
operations, for working capital and for general corporate purposes, including
the following: capital expenditures, clinical development, manufacturing,
in-licensing of technology and/or for other purposes.

         Our largest stockholder is a group of investment managers and funds
associated with Scott Sacane. As of the completion of our sale of shares in our
recent public offering, Mr. Sacane and the related investment managers (the
"Sacane Group") beneficially owned 29.1% of our outstanding common stock. The
Sacane Group accumulated this stock in numerous transactions that were not
reported under Section 16(a) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act"), until filings made on July 31, 2003, which reported both
purchases and sales between May 29, 2002 and July 24, 2003. In addition, the
Sacane Group had




2

not disclosed to us any changes in its beneficial ownership after November 8,
2002, the date of the Schedule 13G they filed reporting beneficial ownership of
6,390,217 shares, or 21.8% of our then outstanding common stock, until July 25,
2003, when the Sacane Group advised us that it had become the beneficial owner
of 9,726,900 shares, or almost 33%, of our outstanding common stock, which it
reported in a Schedule 13D filed on July 29, 2003. As a result of this
information, on July 29, 2003, we amended our stockholder rights agreement to
provide that the Sacane Group would not be an "Acquiring Person" under that
agreement unless and until the earlier of such time as the Sacane Group becomes
the beneficial owner of more than 33% of our outstanding common stock or ceases
to hold any of the common stock of which it is the beneficial owner without any
intention of changing or influencing control of the Company. In addition, we
determined that it was in the best interests of our stockholders to enter into
an agreement with the Sacane Group in which it agreed not to acquire beneficial
ownership of more than 33% of our common stock and not to sell any shares of our
common stock prior to October 29, 2003. (In connection with our public offering,
the Sacane Group agreed not to sell any shares prior to January 31, 2004.) On
August 25, 2003, we filed a complaint in the U.S. District Court for the
District of Connecticut to recover short-swing profits under Section 16(b) of
the Exchange Act and to obtain other relief from the Sacane Group and the Durus
Life Sciences Master Fund, Ltd. (the "Master Fund"), through which the Sacane
Group beneficially owned a large amount of its shares. We had been informed on
July 29, 2003 that the Sacane Group had acknowledged its liability to the
Company under Section 16(b) of the Exchange Act. Since that time, we have been
in discussions with, and are in the process of seeking to resolve our claims
against, the Master Fund. We are also responding to an SEC subpoena and an
inquiry by the Nasdaq relating to the Sacane Group and trading in our shares.




                                  OUR STRATEGY

               Our objective is to discover, develop and commercialize therapies
to address significant unmet needs associated with cardiovascular disease by
exploiting the beneficial properties of HDL. The key elements of our business
strategy are as follows:

         o        discover novel cardiovascular product candidates that overcome
                  limitations of existing treatments;

         o        develop and commercialize a portfolio of drug candidates
                  focused on enhancing the RLT pathway, utilizing the beneficial
                  properties of HDL;

         o        leverage the scientific, drug discovery and drug development
                  expertise and experience of our management team;

         o        enter into strategic collaborations with established
                  pharmaceutical companies in which we retain co-development and
                  co-promotion rights to our biopharmaceutical product
                  candidates; and

         o        focus on the development of biopharmaceutical product
                  candidates for acute treatments and orally active small
                  molecules for chronic therapies to complement statins and
                  other lipid regulating treatments.




3



                             ADDITIONAL INFORMATION

         We were incorporated in Delaware and commenced operations in July 1998.
We became a public company in August 2000 and our common stock trades on The
Nasdaq National Market under the symbol "ESPR." Our executive offices and
primary research facility are located at 3621 South State Street, 695 KMS Place,
Ann Arbor, Michigan 48108; our telephone number is (734) 332-0506; and our
website is http://www.esperion.com. The information on our website is not
incorporated into, and does not constitute any part of, this prospectus.

                                  RISK FACTORS

         INVESTING IN OUR COMMON STOCK INVOLVES A HIGH DEGREE OF RISK. YOU
SHOULD CONSIDER CAREFULLY THE FOLLOWING RISK FACTORS, IN ADDITION TO THE OTHER
INFORMATION IN THIS PROSPECTUS, BEFORE MAKING AN INVESTMENT DECISION. EACH OF
THESE RISK FACTORS COULD ADVERSELY AFFECT OUR BUSINESS, OPERATING RESULTS AND
FINANCIAL CONDITION, AND THE VALUE OF AN INVESTMENT IN OUR COMMON STOCK.


RISKS RELATED TO OUR COMPANY

WE ARE A DEVELOPMENT STAGE BIOPHARMACEUTICAL COMPANY WITH A HISTORY OF LOSSES,
AND, EVEN IF OUR PRODUCT CANDIDATES ARE APPROVED AND COMMERCIALIZED, WE MAY
NEVER BE PROFITABLE.

         We have devoted substantially all of our resources since we began our
operations in July 1998 to the research and development of product candidates
for cardiovascular disease. We have incurred substantial losses since we began
our operations. These losses have resulted principally from costs incurred in
our research and development programs, from our general and administrative
expenses and from acquisition-related costs from our September 2000 acquisition
of Talaria Therapeutics, Inc. To date, we have not generated revenue from
product sales or royalties, and we do not expect to achieve any revenue from
product sales or royalties until we receive regulatory approval and begin
commercialization of our product candidates. We are not certain of when, if
ever, that will occur. We expect to incur significant additional operating
losses for at least the next several years. Research and development costs
relating to our product candidates will continue to increase. Manufacturing,
sales and marketing costs will increase as we prepare for the commercialization
of our product candidates.

         All of our current product candidates are in early stages of
development, and we face the risks of failure inherent in developing drugs based
on new technologies. Because our product development strategy is predicated on a
novel treatment approach based upon our understanding of HDL, we have limited
in-house experience with our product candidates. Our product candidates are not
expected to be commercially available for several years, if at all.


THE TECHNOLOGY UNDERLYING OUR PRODUCT CANDIDATES IS UNCERTAIN AND UNPROVEN,
WHICH COULD KEEP OUR PRODUCT CANDIDATES FROM BECOMING COMMERCIALLY SUCCESSFUL.




4


         All of our current product development efforts are based on unproven
technology and therapeutic approaches that have not been widely tested or used
or approved for marketing in any country. To date, no products that use our
technology have been commercialized. If our product candidates do not work as
intended, or if the data from our clinical trials indicate that our product
candidates are not safe and effective, the applicability of our technology for
treating cardiovascular disease will be highly uncertain. For example, the
future of ETC-216 may be called into question and the market price of our common
stock could decline if the information that we ultimately release about the
recently completed ETC-216 trial with respect to the patients who did not
receive ETC-216 suggests that ETC-216 will not produce a statistically
significant regression of atherosclerosis as compared to the current treatment
for acute coronary syndromes. In June 2003, we announced initial results from
this trial that demonstrated statistically significant regression of
atherosclerosis at the end of six weeks. We did not announce, however, the
results of plaque volume measurements taken at the beginning and end of a
six-week period in the limited number of patients in the trial who did not
receive ETC-216 but who continued to receive their current treatments. We have
not released this information publicly yet because the primary endpoint of the
trial was not designed to compare the results of this non-treatment group with
the treatment groups, and because of our need to comply with non-disclosure
rules applied by medical journals, including those to which the manuscript of
this study might be submitted. Even if the information that we ultimately
release with regard to the non-treatment group is not inconsistent with the
recently announced favorable initial trial results, this would not mean that
ETC-216 would reduce the number of clinical events resulting from cardiovascular
disease. As a result, there is a significant risk that our therapeutic
approaches will not prove to be successful, and there can be no guarantee that
our drug discovery technology will result in any commercially successful
products.


ALL OF OUR PRODUCT CANDIDATES MUST BE TESTED AND SUBMITTED TO THE FDA AND
FOREIGN REGULATORY AGENCIES FOR APPROVAL BEFORE WE CAN SELL THEM IN THE UNITED
STATES OR OTHER COUNTRIES, AND EVEN IF OUR PRODUCT CANDIDATES RECEIVE REGULATORY
APPROVAL, THAT APPROVAL MAY BE LIMITED, WHICH WOULD HINDER OUR ABILITY TO
COMMERCIALIZE THEM.

         Our product candidates must satisfy rigorous standards of safety and
efficacy before they receive regulatory approval in the United States and other
countries. We will need to conduct significant additional research, including
additional pre-clinical testing involving animals and clinical trials involving
humans, before we can file applications for product approval.

         Many of the product candidates in the pharmaceutical and
biopharmaceutical industries do not successfully complete pre-clinical testing
and clinical trials. Satisfaction of regulatory requirements typically takes
many years, is dependent upon the type, complexity and novelty of the product
and requires the expenditure of substantial resources. Success in pre-clinical
testing and early clinical trials does not ensure that later clinical trials
will be successful. For example, a number of companies in the pharmaceutical
industry, including biotechnology companies, have suffered significant setbacks
in advanced clinical trials, even after promising results in earlier trials and
in interim analyses. In addition, delays or rejections may be encountered based
upon additional government regulations, including any changes in FDA policy,
during the process of product development, clinical trials and regulatory
approvals.

         In order to receive regulatory approval from U.S. or foreign regulatory
authorities to market a product, we must demonstrate through human clinical
trials that the product candidate is safe and effective for the treatment of a
specific condition. Even if we believe that the clinical trials demonstrate
safety and efficacy of a



5


product, the FDA and foreign regulatory authorities may not accept our
assessment of the results and may require us to conduct additional advanced
clinical trials.

         Approval of a product by applicable regulatory authorities is necessary
in foreign countries prior to the commencement of marketing of the product in
those countries, whether or not U.S. regulatory approval has been obtained. The
approval procedure varies among countries and can involve additional testing.
The time required may differ from that required for U.S. regulatory approval.
Although there are some procedures for unified filings for some European
countries with the sponsorship of the country that first granted marketing
approval, in general, each country has its own procedures and requirements, many
of which are time consuming and expensive.

         We do not know whether planned clinical trials will begin on time or
will be completed on schedule or at all. If we experience significant delays in
testing or approvals, or if we need to perform more or larger clinical trials
than planned, our product development costs will increase. Any of our future
clinical studies might be delayed or halted because the drug is not safe and
effective, or physicians think that the drug is not safe or effective; patients
do not enroll in the studies at the rate we expect; or drug supplies are not
sufficient to treat the patients in the studies.

         Any regulatory approvals in the United States that we receive in the
future could also include significant restrictions on the use or marketing of
any future products. Product approvals, if granted, can be withdrawn for failure
to comply with regulatory requirements or upon the occurrence of adverse events
following commercial introduction of the products.


IF WE FAIL TO OBTAIN THE CAPITAL NECESSARY TO FUND OUR OPERATIONS, WE WILL BE
UNABLE TO SUCCESSFULLY DEVELOP OUR PRODUCT CANDIDATES OR RETAIN RIGHTS TO OUR
PRODUCT CANDIDATES.

         Significant additional capital will be required in the next several
years to fund our operations. Our current available capital is sufficient to
fund our currently planned operations, capital expenditures and debt service
until at least the end of 2005. We do not know whether additional financing will
be available on acceptable terms when needed. We have used substantial cash
resources to date and expect capital outlays and operating expenditures to
increase over the next several years as we expand our infrastructure and
research and development activities. If adequate funds are unavailable, we may
be required to:

         o        delay, reduce the scope of or eliminate one or more of our
                  research or development programs;

         o        license rights to our technology or product candidates on
                  terms that are less favorable to us than might otherwise be
                  available; or

         o        obtain funds through arrangements that may require us to
                  relinquish rights to all or some of our product candidates
                  that we would otherwise seek to develop or commercialize
                  ourselves.


OUR FREEDOM TO OPERATE OUR BUSINESS OR PROFIT FULLY FROM ANY SALES OF OUR FUTURE
PRODUCTS MAY BE LIMITED DEPENDING UPON THE TERMS OF ANY COLLABORATIVE AGREEMENTS
INTO WHICH WE ENTER, AND THE INABILITY TO ESTABLISH ONE OR MORE COLLABORATIVE
ARRANGEMENTS COULD ADVERSELY AFFECT OUR ABILITY TO DEVELOP AND COMMERCIALIZE
PRODUCTS.




6


         We are seeking to collaborate with pharmaceutical companies to gain
access to their drug development, regulatory, manufacturing, marketing, sales
and financial resources. However, we may not be able to negotiate arrangements
with partners on favorable terms, if at all, or enter into collaborations that
will be commercially successful. Our ability to enter into collaborative
arrangements relating to less than all of our biopharmaceutical product
candidates may be adversely affected by the similarities among those product
candidates. Any collaborative relationships that we enter into may include
restrictions on our freedom to operate our business or may limit any sales of
our future products. If a collaborative arrangement is established, the
collaborative partner may discontinue funding any particular program or may,
either alone or with others, pursue alternative technologies or indications or
develop alternative product candidates for the diseases we are targeting.
Competing products, developed by a collaborative partner or to which a
collaborative partner has rights, may result in the collaborative partner
withdrawing support as to all or a portion of our technology.

         Our ability to enter into a collaborative arrangement for ETC-216 may
be limited by the terms of our agreement with Pharmacia Corporation. Pharmacia
has the right to co-develop and exclusively market ETC-216 outside the United
States and Canada once we complete Phase IIb clinical trials and a right of
first negotiation if we wish to pursue a co-development and co-promotion
arrangement in the United States and Canada. If Pharmacia does not exercise its
right to co-develop and market ETC-216 outside the United States and Canada, or
if it does not choose to participate in co-development and co-promotion within
the United States and Canada, other potential partners may not be willing to
enter into an agreement relating to ETC-216. If we decide to seek a
co-development and co-promotion arrangement in the United States and Canada
prior to completion of Phase IIb clinical trials and Pharmacia does not respond
to our request that they advise us whether they want to exercise their right of
first negotiation, we may need to agree to indemnify our partner from any claims
made by Pharmacia that we have breached our agreement with it.

         Without collaborative arrangements, we must fund our own research,
development, manufacturing, marketing and sales activities, which would
accelerate the depletion of our cash and require us to raise substantial
additional cash to enable us to develop our own development, regulatory,
manufacturing, marketing and sales capabilities. Therefore, if we are unable to
establish and maintain satisfactory collaborative arrangements and if other
sources of cash are not available, we could experience a material adverse effect
on our ability to develop products and, if developed and approved, to
manufacture, market and sell them successfully.


WE EXPECT OUR QUARTERLY AND ANNUAL RESULTS TO FLUCTUATE SIGNIFICANTLY.

         During the next several years, we expect our quarterly and annual
operating results to fluctuate significantly, depending primarily on the
following factors:

         o        timing of pre-clinical studies and clinical trials;

         o        interruptions or delays in the supply of our product
                  candidates or components;

         o        timing of payments to licensors and other third parties;

         o        whether we enter into collaboration agreements and the timing
                  and accounting treatment of payments, if any, to us under
                  those agreements;

         o        timing of patent prosecution and maintenance fees and costs;

         o        timing of investments in new technologies; and

         o        other costs, which may be unexpected.




7


IF THE THIRD-PARTY CLINICAL RESEARCH ORGANIZATIONS THAT WE RELY ON TO CONDUCT
OUR CLINICAL TRIALS DO NOT PERFORM IN AN ACCEPTABLE AND TIMELY MANNER, OR IF WE
ARE NOT ABLE TO MANAGE OR ADMINISTER MULTIPLE CLINICAL TRIALS SIMULTANEOUSLY,
OUR CLINICAL TRIALS COULD BE DELAYED, HALTED OR UNSUCCESSFUL, AND WE COULD BE
UNABLE TO COMMERCIALIZE OUR PRODUCT CANDIDATES ON A TIMELY BASIS, IF AT ALL.

         We do not currently have the ability to independently conduct clinical
trials and obtain regulatory approvals for our product candidates, and we
currently rely and intend to continue to rely on third-party clinical
investigators and contract research organizations to perform these functions. If
we cannot locate acceptable contractors to run our clinical trials or enter into
favorable agreements with them, or if these third parties do not successfully
carry out their contractual duties or meet expected deadlines, we will be unable
to obtain required approvals and will be unable to commercialize our product
candidates on a timely basis, if at all.

         Our clinical studies may also be limited by, delayed or halted because
of the nature of the clinical study; the size of the potential patient
population; the distance between patients and the clinical trial sites; the
number of trials utilizing the same patient population; delays in enrolling
patients; or the eligibility and exclusion criteria for patients in the trial.

         To date, we have not managed multiple late-stage clinical trials
simultaneously. As of June 30, 2003, we have completed six clinical trials (two
of which were conducted through a company that we acquired) and have five
clinical trials in progress. It may be difficult or we may be unable to retain
individuals qualified to administer these and future late-stage clinical trials
due to the complexity of the protocols and the size of the studies. We may be
unable to complete multiple late-stage clinical trials concurrently as
effectively or as quickly as we currently anticipate, which could have a
material adverse effect on our business, financial condition and results of
operations.


IF OUR CURRENT AND FUTURE MANUFACTURING AND SUPPLY STRATEGIES ARE UNSUCCESSFUL,
WE MAY BE UNABLE TO COMPLETE ANY FUTURE CLINICAL TRIALS OR COMMERCIALIZE OUR
PRODUCT CANDIDATES IN A TIMELY MANNER, IF AT ALL.

         Completion of our clinical trials and commercialization of our product
candidates will require access to, or development of, facilities to manufacture
a sufficient supply of our product candidates. We do not have the resources,
facilities or experience to manufacture our product candidates on our own and do
not intend to develop or acquire facilities for the manufacture of product
candidates for clinical trials or commercial purposes in the foreseeable future.
We currently rely, and will continue to rely, on contract manufacturers to
produce sufficient quantities of our product candidates. We are currently
exploring ways to improve the manufacturing process for our ETC-216 product
candidate, as the yield from the current process will need to be enhanced in
order to meet late-stage clinical trial supply and commercial-scale
requirements. If we are unable to improve the current manufacturing process, we
may be unable to complete future clinical trials for, or to cost-effectively
commercialize, this product candidate. Most of our contract manufacturers have
limited experience with manufacturing, formulating, analyzing, filling and
finishing our particular product candidates. Our manufacturing strategy presents
the following difficulties:

         o        we may not be able to locate acceptable manufacturers or enter
                  into favorable long-term agreements with them;




8


         o        third parties may not be able to manufacture our product
                  candidates successfully in a cost-effective or timely manner
                  or in quantities needed for clinical trials or commercial
                  sales;

         o        delays in, or failures to achieve, scale-up to commercial
                  quantities, or changes to current raw material suppliers or
                  product manufacturers (whether the change is attributable to
                  us or the vendor) could delay clinical studies, regulatory
                  submissions and commercialization of our product candidates;

         o        we may not have intellectual property rights, or may have to
                  share intellectual property rights, to the manufacturing
                  processes for our product candidates;

         o        manufacturing and validation of manufacturing processes and
                  materials are complicated and time-consuming and may not
                  provide yields adequate to meet clinical trial supply or
                  commercial scale-up requirements;

         o        because many of our current third-party manufacturers are
                  located outside of the United States, there may be
                  difficulties in importing our product candidates or their
                  components into the United States as a result of, among other
                  things, FDA import inspections, increased customs security
                  measures, incomplete or inaccurate import documentation, or
                  defective packaging; and

         o        manufacturers of our product candidates are subject to the
                  FDA's current Good Manufacturing Practices regulations, the
                  FDA's current Good Laboratory Practices regulations and
                  comparable foreign standards and we do not have control over
                  compliance with these regulations by our third-party
                  manufacturers.

         If any manufacturer of our product candidates fails to comply with
applicable FDA or other regulatory requirements including manufacturing, quality
control, labeling, safety surveillance, promoting and reporting, such failure
may result in our criminal prosecution, levy of civil penalties against us,
recall or seizure of any of our future products, total or partial suspension of
production or an injunction, as well as other regulatory actions against our
manufacturers, our potential products or us. Discovery of previously unknown
problems with a product, supplier, manufacturer or facility may result in
restrictions on the sale of a future product, including a withdrawal of the
product from the market.


IF ONE OF OUR BIOPHARMACEUTICAL PRODUCT CANDIDATES DOES NOT SHOW SAFETY AND
EFFICACY IN EARLY CLINICAL TRIALS, IT COULD IMPACT THE DEVELOPMENT PATH FOR OUR
OTHER BIOPHARMACEUTICAL PRODUCT CANDIDATES BECAUSE OF THE SIMILARITIES IN THE
TECHNOLOGY FOR EACH OF OUR BIOPHARMACEUTICAL PRODUCT CANDIDATES.

         The development of each of our biopharmaceutical product candidates
(ETC-588, ETC-216 and ETC-642) is based on our knowledge and understanding of
HDL and how HDL contributes to the RLT pathway. While there are important
differences in each of the product candidates in terms of their composition and
properties, each product candidate is focused on affecting various steps in the
RLT pathway. In addition, all three of the biopharmaceutical product candidates
are infused, rather than orally administered, and are currently being targeted
for the treatment of patients with acute coronary syndromes.

         As a result of these similarities, our product candidates may be
perceived to have overlapping utility in the treatment of cardiovascular
disease. Since we are developing these product candidates in parallel, we expect
to learn from the results of each trial and apply some of our findings to the
development of the other product candidates. If one of the product candidates
has negative clinical trial results or is shown to be ineffective, it could
impact the development path or future development of the other biopharmaceutical
product candidates. If we find that one of the biopharmaceutical product
candidates is unsafe, we may be unable to raise sufficient





9


capital to fund the development of the other biopharmaceutical product
candidates due to any resultant negative perceptions about HDL as an infused,
acute treatment for cardiovascular disease.


IF WE FAIL TO SECURE AND ENFORCE PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS
UNDERLYING OUR PRODUCT CANDIDATES AND TECHNOLOGY, WE MAY BE UNABLE TO DEVELOP
OUR PRODUCT CANDIDATES OR COMPETE EFFECTIVELY.

         The pharmaceutical and biopharmaceutical industries place considerable
importance on obtaining patent and trade secret protection for new technologies,
products and processes. Our success will depend, in part, on our ability, and
the ability of our licensors, to obtain and enforce our exclusive rights to our
product candidates and technology under the patent laws of the United States and
other countries. Our success also will depend on our ability to prevent others,
including our employees, from using our trade secrets, know how and other
confidential information. In addition, we must operate in a way that does not
infringe, or violate, the patent, trade secret and other intellectual property
rights of other parties.

         The standards that the United States Patent and Trademark Office uses
to grant patents can change. Consequently, we may be unable to determine the
type and extent of patent claims that will be issued to us or to our licensors
in the future. Any patents issued may not contain claims that will permit us to
stop competitors from using the same or similar technology.

         Patent prosecution and maintenance are also very costly and successful
prosecution and defense may depend on the patent strategies that are pursued.

         The standards that courts use to interpret patents can change,
particularly as new technologies develop. Consequently, we cannot know how much
protection, if any, our patents will provide. If we choose to seek a court order
that prohibits a third party from using the inventions claimed in our patents,
the third party may ask the court to rule that our patents are invalid and
unenforceable. This type of lawsuit is expensive and time consuming and could be
unsuccessful. There is also the risk that, even if the validity of our patents
is upheld, the court will refuse to stop the third party on the ground that its
activities do not infringe the patent.


IF OUR LICENSING ARRANGEMENTS WITH THIRD PARTIES ARE BREACHED OR TERMINATED, WE
MAY LOSE RIGHTS TO COMMERCIALIZE OUR PRODUCT CANDIDATES.

         We license most of the technology for our biopharmaceutical product
candidates from third parties. We depend, and will continue to depend, on these
and other licensing arrangements. If any of our licenses with third parties are
terminated or breached, we may lose our rights to develop and commercialize our
product candidates or lose patent or trade secret protection for our product
candidates.

         Disputes may arise with respect to our licensing agreements and
strategic relationships regarding ownership rights to technology developed by or
with other parties or with respect to manufacturing, development and other
strategies and decisions. Such disputes could lead to delays in or termination
of the research, development, manufacture and commercialization of our product
candidates, or to litigation.



10


WE MAY FACE SIGNIFICANT EXPENSE AND LIABILITY AS A RESULT OF LITIGATION OR OTHER
PROCEEDINGS RELATING TO PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS OF THIRD
PARTIES, WHICH COULD REDUCE OUR AVAILABLE CAPITAL.

         If third parties file patent applications, or are issued patents,
claiming technology also claimed by us or our licensors in pending applications
or issued patents, we may be required to participate in interference proceedings
in the United States Patent and Trademark Office to determine priority of
invention. An adverse outcome in an interference proceeding could require us to
forfeit our patents or applications involved in the interference, cease using
the technology or license rights from prevailing third parties. We could also be
subject to allegations of trade secret violations and other claims relating to
the intellectual property rights of third parties.


IF PRODUCT LIABILITY LAWSUITS ARE SUCCESSFULLY BROUGHT AGAINST US, WE MAY INCUR
SUBSTANTIAL LIABILITIES AND MAY BE REQUIRED TO LIMIT COMMERCIALIZATION OF ANY OF
OUR FUTURE PRODUCTS.

         Our business exposes us to product liability risks that are inherent in
the clinical testing, manufacturing, marketing and sale of pharmaceutical and
biopharmaceutical products. We may not be able to avoid product liability
claims. Product liability insurance for the pharmaceutical and biopharmaceutical
industries is generally expensive, if available at all. We have clinical trial
liability insurance for our product candidates in clinical trials; however,
there can be no assurance that such insurance coverage is or will continue to be
adequate or available. We may not be able to secure greater or broader product
liability insurance coverage on acceptable terms or at reasonable costs when
needed. If we are unable to obtain sufficient insurance coverage on reasonable
terms or to otherwise protect against potential product liability claims, we may
be unable to commercialize our product candidates. A successful product
liability claim brought against us for damages in an amount that exceeds our
insurance coverage, if any, may cause us to incur substantial liabilities and
our business may fail.


IF OUR COMPETITORS DEVELOP AND COMMERCIALIZE PRODUCTS FASTER THAN WE DO OR
COMMERCIALIZE PRODUCTS THAT ARE SUPERIOR TO OUR PRODUCT CANDIDATES, OUR
COMMERCIAL OPPORTUNITIES WILL BE REDUCED OR ELIMINATED.

         The extent to which any of our product candidates achieve market
acceptance will depend on competitive factors, many of which are beyond our
control. Competition in the pharmaceutical and biopharmaceutical industries is
intense and has been accentuated by the rapid pace of technology development.
Our competitors include large fully-integrated pharmaceutical companies,
biopharmaceutical companies, biotechnology companies, universities and public
and private research institutions. Many of these entities have substantially
greater research and development capabilities and financial, scientific,
manufacturing, marketing and sales resources than we do, as well as more
experience in research and development, clinical trials, regulatory matters,
manufacturing, marketing and sales. These organizations also compete with us to:

         o        attract parties for collaborations, joint ventures or
                  acquisitions;

         o        license the proprietary technology that is competitive with
                  our technology;

         o        attract funding; and

         o        attract and hire scientific talent.



11


         Our competitors may succeed in developing and commercializing products
earlier, and obtaining regulatory approval more rapidly, than we do. Our
competitors may also develop products or technologies that are superior to those
we are developing, and render our product candidates or technology obsolete or
non-competitive. If we cannot successfully compete with new or existing
products, our marketing and sales would suffer and we may not ever be
profitable.


OUR PRODUCT CANDIDATES MAY NOT BE COMMERCIALLY SUCCESSFUL BECAUSE PHYSICIANS,
PATIENTS AND GOVERNMENT AGENCIES AND OTHER THIRD-PARTY PAYORS MAY NOT ACCEPT
THEM.

         Even if regulatory authorities approve our product candidates, they may
not be commercially successful. Third parties may develop superior products or
less costly alternative products, or have proprietary rights that preclude us
from marketing any of our future products. We also expect that most of our
product candidates will be considered expensive, if approved. Patient acceptance
of and demand for any product candidates for which we obtain regulatory approval
will also depend upon acceptance by physicians of any of our product candidates
as safe and effective therapies and the extent, if any, of reimbursement of drug
and treatment costs by government agencies and other third-party payors.

         In addition, any of our product candidates could cause adverse events,
such as immunologic or allergic reactions. These reactions may not be observed
in clinical trials, but may nonetheless occur after commercialization. If any of
these reactions occur, they may render any commercialized product ineffective in
some patients and thereby hinder the sales of such product.


OUR FAILURE TO OBTAIN AN ADEQUATE LEVEL OF REIMBURSEMENT OR ACCEPTABLE PRICES
FOR ANY OF OUR FUTURE PRODUCTS COULD DIMINISH ANY REVENUES WE MAY BE ABLE TO
GENERATE.

         Our ability to commercialize any future products successfully, alone or
with collaborators, will depend in part on the extent to which reimbursement for
the products will be available from:

         o        government and health administration authorities;

         o        private health insurers; and

         o        other third-party payors.

         Government and other third-party payors increasingly are attempting to
contain healthcare costs by limiting both coverage and the level of
reimbursement for new drugs. Third-party private health insurance coverage may
not be available to potential patients for any of our future products.

         The continuing efforts of government and other third-party payors to
contain or reduce the costs of healthcare through various means may limit our
commercial opportunity and reduce any associated revenue and profits. We expect
proposals to implement similar government control to continue. In addition,
increasing emphasis on managed care will continue to put pressure on the pricing
of pharmaceutical and biopharmaceutical products. Cost control initiatives could
decrease the price that we or any potential collaborators could receive for any
of our future products and could adversely affect our profitability. In
addition, in some countries other than the United States, pricing and
profitability of prescription pharmaceuticals and biopharmaceuticals are subject
to government control.




12



EVEN IF WE OBTAIN REGULATORY APPROVAL OF ANY OF OUR PRODUCT CANDIDATES, WE WILL
NOT BE ABLE TO SUCCESSFULLY COMMERCIALIZE SUCH PRODUCT CANDIDATES IF WE ARE
UNABLE TO CREATE SALES, MARKETING AND DISTRIBUTION CAPABILITIES OR ENTER INTO
APPROPRIATE COLLABORATIVE ARRANGEMENTS.

         In order to commercialize any of our product candidates successfully,
we must either internally develop full and efficient sales, marketing and
distribution capabilities or make arrangements with third parties to perform
these services. We have no experience in developing, training or managing a
sales force and will incur substantial additional expenses in doing so. The cost
of establishing and maintaining a sales force may exceed its cost effectiveness.
In addition, we will compete with many companies that currently have extensive
and well-funded marketing and sales operations. Our marketing and sales efforts
may be unable to compete successfully against these companies.


IF WE FAIL TO RECRUIT, RETAIN AND MOTIVATE SKILLED PERSONNEL, OUR PRODUCT
DEVELOPMENT PROGRAMS, OUR RESEARCH AND DEVELOPMENT EFFORTS AND THE RELEASE OF
OUR PRODUCT CANDIDATES MAY BE DELAYED.

         Our success depends on our ability to recruit, retain and motivate
highly-qualified management and scientific personnel, including skilled chemists
and clinical development personnel, for which competition is intense. Our loss
of the services of any of our key personnel, in particular, Roger S. Newton,
Ph.D., our President and Chief Executive Officer, could significantly impede the
achievement of our research and development objectives and could delay our
product development programs and strategies.


IF WE USE BIOLOGICAL AND HAZARDOUS MATERIALS IN A MANNER THAT CAUSES INJURY, WE
MAY BE LIABLE FOR DAMAGES.

         Our research and development activities involve the controlled use of
potentially harmful biological materials as well as hazardous materials,
chemicals and various radioactive compounds. We cannot completely eliminate the
risk of accidental contamination or injury from the use, storage, handling or
disposal of these materials. In the event of contamination or injury, we could
be held liable for damages, and such liability could exceed our resources. We
are subject to federal, state, local and international laws and regulations
governing the use, storage, handling and disposal of these materials and
specified waste products. The cost of compliance with these laws and regulations
could become significant.


RISKS RELATED TO THIS OFFERING

OUR COMMON STOCK PRICE HAS BEEN VOLATILE AND COULD EXPERIENCE A SUBSTANTIAL
DECLINE IN VALUE.

         The market price of our common stock has historically experienced and
may continue to experience volatility. During the 12 months ended September 30,
2003, the market price of our common stock ranged from $5.19 to $21.00 per
share. The closing market price of our common stock decreased from a closing
price of $20.49 on Friday, July 25, 2003, to a closing price of $13.98 on
Wednesday, August 11, 2003. On July 29, 2003, we disclosed that our largest
stockholder, the Sacane Group, had represented that it owned approximately 33%
of our common stock and had agreed to certain voting and transfer restrictions.
The volume of trading in




13

our stock, as well as the stock price, may have been, and may be in the future,
adversely affected by these transfer restrictions because the Sacane Group's
transactions in our shares of common stock represented approximately 25% of the
market transactions in our common stock during the period from September 3, 2002
to July 24, 2003. This volume of trading by the Sacane Group may have caused our
stock price during that period to be higher than it otherwise would have been.
In addition, if the stockholder does not comply with the transfer restrictions
or rumors continue to exist in the market that the stockholder will sell its
shares notwithstanding the transfer restrictions, the market price of our common
stock may continue to be volatile.

         In addition, our quarterly operating results, announcements of
collaborations, the success or failure of the drug development efforts of our
collaborators, technological innovations being developed by us or our
competitors, changes in general conditions in the economy or the financial
markets and other developments affecting our competitors, our collaborators or
us could cause the market price of our common stock to fluctuate substantially.
In addition, in recent years, the stock market in general, and the market for
pharmaceutical and biopharmaceutical companies in particular, have experienced
significant price and volume fluctuations. This volatility has affected the
market prices of securities issued by many companies, often for reasons
unrelated to their operating performance, and may adversely affect the price of
our common stock.

         In the past, securities class action litigation has often been
instituted following periods of volatility in the market price of a company's
securities. A securities class action suit against us could result in potential
liabilities, substantial costs and the diversion of management's attention and
resources, regardless of whether we win or lose.


OUR SHARE OWNERSHIP IS CONCENTRATED, AND OUR OFFICERS, DIRECTORS AND PRINCIPAL
STOCKHOLDERS MAY EXERT SIGNIFICANT CONTROL OVER CHANGES IN THE PRICE OF OUR
SECURITIES, OUR BUSINESS AND MATTERS REQUIRING STOCKHOLDER APPROVAL.

         Our largest stockholder is a group of investment managers and funds
associated with Scott Sacane. As of the completion of our sale of shares in our
recent public offering, Mr. Sacane and the related investment managers (the
"Sacane Group") beneficially owned 29.1% of our outstanding common stock. The
Sacane Group accumulated this stock in numerous transactions that were not
reported under Section 16(a) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act"), until filings made on July 31, 2003, which reported both
purchases and sales between May 29, 2002 and July 24, 2003. In addition, the
Sacane Group had not disclosed to us any changes in its beneficial ownership
after November 8, 2002, the date of the Schedule 13G they filed reporting
beneficial ownership of 6,390,217 shares, or 21.8% of our then outstanding
common stock, until July 25, 2003, when the Sacane Group advised us that it had
become the beneficial owner of 9,726,900 shares, or almost 33%, of our
outstanding common stock, which it reported in a Schedule 13D filed on July 29,
2003. As a result of this information, on July 29, 2003, we amended our
stockholder rights agreement to provide that the Sacane Group would not be an
"Acquiring Person" under that agreement unless and until the earlier of such
time as the Sacane Group becomes the beneficial owner of more than 33% of our
outstanding common stock or ceases to hold any of the common stock of which it
is the beneficial owner without any intention of changing or influencing control
of the Company. In addition, we determined that it was in the best interests of
our stockholders to enter into an agreement with the Sacane Group in which it
agreed not to acquire beneficial ownership of more than 33% of our common stock
and not to sell any shares of our common stock prior to October 29, 2003. (In
connection with our public offering, the Sacane Group agreed not to sell any
shares prior to January 31, 2004.) There can be no assurance that the voting and
transfer restrictions the Sacane Group has



14


agreed to will not be breached, intentionally or unintentionally, in the future
and that, as a result, our share price is negatively affected.

         On August 31, 2003, our directors and officers and stockholders known
to us to hold more than 5% of our common stock beneficially owned on an
aggregate basis approximately 33% of our outstanding common stock. Collectively
and notwithstanding the voting restrictions applicable to the Sacane Group as
discussed above, these stockholders may have the ability to significantly
influence the outcome of all corporate matters requiring stockholder approval.
Therefore, they may vote their shares in a way with which you do not agree. In
particular, this concentration of ownership may have the effect of delaying,
deferring or preventing an acquisition of us and may adversely affect the market
price of our common stock.


FUTURE SALES OF OUR COMMON STOCK MAY DEPRESS OUR STOCK PRICE.

         The market price of our common stock could decline as a result of sales
of substantial amounts of our common stock in the public market, or the
perception that these sales could occur. In addition, these factors could make
it more difficult for us to raise funds through future offerings of common
stock.

         As of August 31, 2003, we have an aggregate of 4,368,584 shares of
common stock that have been registered and are reserved for issuance upon
exercise of options granted or reserved for grant under our 2000 Equity
Compensation Plan, our 1998 Stock Option Plan and our Employee Stock Purchase
Plan. Stockholders can sell these shares in the public market upon issuance,
subject to restrictions under the securities laws. In addition, some of our
existing stockholders will be entitled to register their shares of common stock
after this offering.


ANTI-TAKEOVER PROVISIONS IN OUR CHARTER DOCUMENTS, UNDER DELAWARE LAW AND UNDER
OUR STOCKHOLDER RIGHTS PLAN COULD MAKE AN ACQUISITION OF US MORE DIFFICULT.

         o        Provisions of our amended and restated certificate of
                  incorporation and amended and restated bylaws will make it
                  more difficult for a third party to acquire us on terms not
                  approved by our board of directors and may have the effect of
                  deterring hostile takeover attempts. For example, our amended
                  and restated certificate of incorporation currently authorizes
                  our board of directors to issue substantial amounts of
                  preferred stock and to fix the price, rights, preferences,
                  privileges and restrictions, including voting rights, of those
                  shares without any further vote or action by the stockholders.
                  The rights of the holders of our common stock will be subject
                  to, and may be harmed by, the rights of the holders of any
                  preferred stock that may be issued in the future. The issuance
                  of preferred stock could reduce the voting power of the
                  holders of our common stock and the likelihood that common
                  stockholders will receive payments upon liquidation. In
                  addition, our amended and restated certificate of
                  incorporation divides our board of directors into three
                  classes having staggered terms.

         o        We are also subject to provisions of Delaware law that could
                  have the effect of delaying, deferring or preventing a change
                  in control of our company. One of these provisions prevents us
                  from engaging in a business combination with any interested
                  stockholder for a period of three years after the date the
                  person becomes an interested stockholder, unless specified
                  conditions are satisfied.



15


         o        We have also implemented a stockholder rights plan, or poison
                  pill, that would substantially reduce or eliminate the
                  expected economic benefit to an acquiror from acquiring us in
                  a manner or on terms not approved by our board of directors.
                  These and other impediments to a third-party acquisition or
                  change of control could limit the price investors are willing
                  to pay in the future for shares of our common stock.


BECAUSE WE DO NOT INTEND TO PAY DIVIDENDS, STOCKHOLDERS WILL BENEFIT FROM AN
INVESTMENT IN OUR COMMON STOCK ONLY IF IT APPRECIATES IN VALUE.

         We have never declared or paid any cash dividends on our common stock.
We currently intend to retain our future earnings, if any, to finance further
research and the expansion of our business and do not expect to pay any cash
dividends in the foreseeable future. As a result, the success of an investment
in our common stock will depend upon any future appreciation in its value. There
is no guarantee that our common stock will appreciate in value or even maintain
the price at which stockholders have purchased their shares.


ARTHUR ANDERSEN LLP HAS NOT CONSENTED TO THE INCORPORATION BY REFERENCE OF THEIR
REPORTS ON OUR FINANCIAL STATEMENTS AND IT MAY NOT BE ABLE TO SATISFY POTENTIAL
CLAIMS AGAINST THEM.

         Arthur Andersen LLP audited our consolidated financial statements for
the two years ended December 31, 2001, and the period from our inception in May
1998 to December 31, 2001 and issued a report thereon dated January 18, 2002,
which are incorporated by reference herein. Arthur Andersen LLP has not reissued
their report on our financial statements and has not consented to the
incorporation by reference of their report on our financial statements in this
prospectus, and we have relied on Rule 437a under the Securities Act in filing
this registration statement without such a consent. On June 15, 2002, Arthur
Andersen LLP was convicted of obstruction of justice by a federal jury in
Houston, Texas in connection with Arthur Andersen LLP's work for Enron Corp. On
September 15, 2002, a federal judge upheld this conviction. Arthur Andersen LLP
ceased its audit practice before the Commission on August 31, 2002. Effective
April 18, 2002, we terminated the engagement of Arthur Andersen LLP as our
independent accountants and engaged PricewaterhouseCoopers LLP to serve as our
independent accountants for the fiscal year ending December 31, 2002. Because
Arthur Andersen LLP has not consented to the incorporation by reference of their
report on our financial statements in this prospectus and because of the
circumstances affecting Arthur Andersen LLP, as a practical matter, it may not
be able to satisfy any claims arising from the provision of auditing services to
us, including claims you may have that are available to securities holders under
federal and state securities laws.

                           FORWARD-LOOKING STATEMENTS

         The information contained in this prospectus, including the information
incorporated by reference into this prospectus, includes "forward-looking
statements" within the meaning of Section 21E of the Securities Exchange Act of
1934, as amended (the "Exchange Act"), and Section 27A of the Securities Act as
enacted by the Private Securities Litigation Reform Act of 1995. These
forward-looking statements are often identified by words such as "hope," "may,"
"believe," "anticipate," "plan," "expect," "require," "intend," "assume" and
similar expressions. We caution readers that forward-looking statements speak
only as of the date of this filing, reflect management's current expectations,
estimations and projections and involve certain factors, such as risks and
uncertainties, that may cause our actual results, performance or achievements to
be far different from those



16


suggested by our forward-looking statements. These factors include, but are not
limited to, risks associated with:

         o        our ability to successfully execute our business strategies,
                  including entering into strategic partnerships or other
                  transactions;

         o        the progress and cost of development of our product
                  candidates;

         o        the extent and timing of market acceptance of new products
                  developed by us or by our competitors;

         o        our dependence on third parties to conduct clinical trials for
                  our product candidates;

         o        the extent and timing of regulatory approval, as desired or
                  required, for our product candidates;

         o        our dependence on licensing arrangements and other strategic
                  relationships with third parties;

         o        clinical trials;

         o        manufacturing;

         o        our dependence on patents and proprietary rights;

         o        procurement, maintenance, enforcement and defense of our
                  patents and proprietary rights;

         o        competitive conditions in the industry;

         o        business cycles affecting the markets in which any of our
                  future products may be sold;

         o        extraordinary events and transactions;

         o        seeking and consummating business acquisitions, including the
                  diversion of management's attention to the assimilation of the
                  operations and personnel of any acquired business;

         o        the timing and extent of our financing needs and our access to
                  funding, including through the equity market;

         o        fluctuations in foreign exchange rates; and

         o        economic conditions generally or in various geographic areas.

         Because all of the foregoing factors are difficult to forecast, you
should not place undue reliance on any forward-looking statements. These and
other risks and uncertainties are discussed above in the section entitled "Risk
Factors." We do not intend to update any of these factors or to publicly
announce the results of any revisions to any of our forward-looking statements
other than as required under the federal securities laws.


                                 USE OF PROCEEDS

         The Company will not realize any proceeds from the sale of the Shares
by the Selling Stockholder.

                               SELLING STOCKHOLDER

         The Selling Stockholder, Franklin Templeton Bank & Trust, F.S.B., is
the trustee of our 401(k) Savings Plan (the "Trustee)." The Selling Stockholder
may from time to time engage in sales of the Common Stock in order to administer
the Plan.




17

         The following table sets forth the name of the Selling Stockholder and
(i) the number of shares of Common Stock beneficially owned by the Selling
Stockholder, as Trustee, on October 10, 2003, (ii) the number of shares of
Common Stock to be issued by the Company to the Selling Stockholder pursuant to
the Plan and being offered hereby, and (iii) the number of shares of Common
Stock and the percentage of the total class of Common Stock outstanding on
October 10, 2003 that will be beneficially owned by the Selling Stockholder, as
Trustee, following the offering.

                               SELLING STOCKHOLDER





                                                                                    NUMBER AND
                                       NUMBER OF             NUMBER OF         PERCENTAGE OF SHARES
                                      SHARES OWNED            SHARES             OWNED AFTER SALE
      NAME OF SELLING                 PRIOR TO THE             BEING             ----------------
        STOCKHOLDER                     OFFERING              OFFERED            # (3)       % (3)
        -----------                   ------------            -------            -----       -----
                                                                                
Franklin Templeton Bank & Trust,
F.S.B., as trustee of the Plan          6,738 (1)            25,000 (2)            __          __




         (1)      Represents Shares that have been issued by the Company to the
                  Trustee as a matching contribution under the Plan with respect
                  to the 2002 Plan year.

         (2)      Represents the estimated number of Shares to be issued by the
                  Company to the Trustee as Company matching contributions under
                  the Plan with respect to subsequent Plan years.

         (3)      Assumes that the Selling Stockholder disposes of all of the
                  Shares covered in this prospectus and does not acquire any
                  additional shares of Common Stock.


                              PLAN OF DISTRIBUTION

         The sale of the Shares by the Selling Stockholder may be effected from
time to time in transactions on The Nasdaq National Market or on such other
exchange or market in which the Common Stock may from time to time be trading,
in negotiated transactions, or a combination of such methods of sale, at fixed
prices that may be changed, at market prices prevailing at the time of sale, at
prices related to such prevailing market prices, or at negotiated prices. The
Selling Stockholder may effect such transactions by selling Shares directly to
purchasers or to or through broker-dealers which may act as agents or
principals. Such broker-dealers may receive compensation in the form of
discounts, concessions or commissions from the Selling Stockholder or the
purchasers of Shares for whom such broker-dealers may act as agent or to whom
they sell as principal, or both (which compensation as to a particular
broker-dealer might be in excess of customary commissions). Any such broker or
dealer may be deemed to be an "underwriter" within the meaning of Section 2(11)
of the Act, and any commissions received by any such broker or dealer in
connection with such sales and any profits received by any such broker or dealer
on the resale of any Shares acquired as principal may be deemed to be
underwriting compensation.

         The Company has agreed to bear all of the expenses incurred by it in
connection with the registration of the Shares, except for any legal fees or
similar expenses incurred by the Selling Stockholder.




18

         The Company is required to indemnify the Selling Stockholder against
various losses, liabilities, costs and expenses pursuant to the Trust Agreement
between the Company and the Selling Stockholder, including liabilities that
arise under the Securities Act. However, the Selling Stockholder shall not be
entitled to indemnification to the extent that its liabilities, losses, costs or
expenses are attributed to its own negligence, willful misconduct or breach of
the Trust Agreement.

                       WHERE YOU CAN FIND MORE INFORMATION

         We file annual, quarterly and current reports, proxy statements and
other information with the Securities and Exchange Commission through the SEC's
Electronic Data Gathering, Analysis and Retrieval, or EDGAR, system. You can
inspect and/or copy these reports and other information at:

         o        the Public Reference Room at the SEC's principal offices
                  located at Judiciary Plaza, 450 Fifth Street, N.W.,
                  Washington, D.C. 20549;

         o        the Public Reference Room at the SEC's principal offices
                  located at Judiciary Plaza, 450 Fifth Street, N.W.,
                  Washington, D.C. 20549; and

         o        the SEC's website at http://www.sec.gov.

         Please call the SEC at 1-800-SEC-0330, or see its website, for further
information about the operation of the Public Reference Room.

                       DOCUMENTS INCORPORATED BY REFERENCE

         We are incorporating by reference into this prospectus the information
that we file with the SEC. This means that we can disclose to you important
information contained in other documents that we file with the SEC by referring
you to those documents. The information incorporated by reference is, therefore,
an important part of this prospectus. We incorporate by reference the documents
listed below and any future filings we make with the SEC under Sections 13(a),
13(c), 14 or 15(d) of the Exchange Act, until all of the shares covered by this
prospectus are sold (other than Current Reports on Form 8-K containing
disclosure furnished under Item 9 or Item 12 and exhibits relating to such
disclosures, unless otherwise specifically stated in any such Current Report on
Form 8-K):

         o        our annual report on Form 10-K for the fiscal year ended
                  December 31, 2002, filed on March 26, 2003;

         o        our quarterly reports on Form 10-Q for the quarter ended March
                  31, 2003, filed on May 14, 2003, and for the quarter ended
                  June 30, 2003, filed on August 14, 2003;

         o        our definitive proxy statement on Schedule 14A for our 2003
                  annual meeting of stockholders, filed on May 14, 2003;

         o        our current report on Form 8-K, filed on July 29, 2003; and

         o        the description of our common stock contained in our
                  registration statement on Form 8-A (filed on August 4, 2000
                  and amended by our current reports on Form 8-K filed on April
                  23, 2002 and July 29, 2003).



19


         Information in reports that we file with the SEC after the date of this
prospectus may contain information that updates, modifies or is contrary to
information in this prospectus or in documents incorporated by reference into
this prospectus. You should review these reports as they may disclose a change
in our business, prospects, financial condition or other affairs after the date
of this prospectus. The information that we file later with the SEC pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act and before the
termination of this offering will automatically update and supercede previously
filed information incorporated by reference into this prospectus.

         We undertake to provide to you, without charge, the documents
incorporated by reference into this prospectus, other than exhibits not
specifically incorporated by reference into such documents. Please make your
request by writing to us at: Esperion Therapeutics, Inc., Attn: Christine K.
Ballman, 3621 South State St., 695 KMS Place, Ann Arbor, MI 48108, or by calling
us at: (734) 332-0506.

                                     EXPERTS

         The financial statements as of and for the year ended December 31, 2002
incorporated in this prospectus by reference to the Annual Report on Form 10-K
for the fiscal year ended December 31, 2002 of Esperion Therapeutics, Inc. have
been so incorporated in reliance on the report of PricewaterhouseCoopers LLP,
independent accountants, given on the authority of said firm as experts in
auditing and accounting. The audited consolidated financial statements and
schedules for our two fiscal years ended December 31, 2001 and incorporated by
reference in this prospectus were audited by Arthur Andersen LLP, our former
independent public accountants, as indicated in their reports with respect
thereto. Copies of such reports are incorporated by reference herein, but Arthur
Andersen LLP has not reissued such reports or consented to the incorporation of
such reports into this prospectus and has ceased operations.







20


                                     PART II

                   INFORMATION NOT REQUIRED IN THE PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

         We will pay the expenses relating to the registration of the shares. We
estimate the expenses to be as follows:


                                                            
SEC Registration Fee .......................................    $ 39.64
Legal Fees and Expenses.....................................    $ 25,000*
Accounting Fees and Expenses................................    $ 3,100*
Printing Expenses...........................................    $ 3,000*
       Total................................................    $ 31,140*



--------
*  Estimated

ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         Esperion Therapeutics, Inc. is a Delaware corporation, subject to the
provisions of the Delaware General Corporation Law. Section 145 of the Delaware
General Corporation Law provides that each Delaware corporation may indemnify
any person who was or is a party or is threatened to be a party to any
threatened, pending or completed action, suit or proceeding, whether civil,
criminal, administrative or investigative, by reason of the fact that he or she
is or was a director, officer, employee or agent of the corporation or serving
another corporation at the request of the corporation, against expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement,
actually and reasonably incurred by him or her if he or she acted in good faith
and in a manner he or she reasonably believed to be in or not opposed to the
best interests of the corporation and, with respect to a criminal action or
proceeding, had no reasonable cause to believe his or her conduct was unlawful.
Lack of good faith is not to be presumed from settlement. No indemnification is
allowed in respect to any proceeding charging improper personal benefit to the
officer or director in which such person was adjudged to be liable on the basis
that personal benefit was improperly received. To the extent any such person
succeeds on the merits or otherwise, he or she shall be indemnified against
expenses (including attorneys' fees). A determination that the person to be
indemnified meets the applicable standard of conduct, if not made by a court, is
made by the Board of Directors by majority vote of a quorum consisting of
directors not party to such action, suit or proceeding or, if a quorum is not
obtainable or a disinterested quorum so directs, by independent legal counsel or
by the stockholders. Expenses may be paid in advance upon receipt of
undertakings to repay. A corporation may purchase indemnification insurance.

         Article VIII of our amended and restated certificate of incorporation
and Section 6.07 of our bylaws provide that our officers, directors, employees
and agents acting in their official capacities are entitled, under certain
conditions, to indemnification against liabilities and expenses. We have not
entered into separate indemnification agreements with any of our officers or
directors.

         Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers or persons controlling us pursuant
to the foregoing provisions, we have been informed that in the opinion of the
SEC such indemnification is against public policy as expressed in the Securities
Act and is therefore unenforceable.



II-1


         We also currently maintain a directors' and officers' liability
insurance policy, insuring our officers and directors against certain
liabilities and expenses incurred by such persons in such capacities. We
consider the maintenance of such insurance coverage to be vital in attracting
and retaining the services of qualified directors and officers. We cannot be
assured, however, that our existing policy will be renewed upon expiration or
that, if the policy is not renewed, we will be able to obtain similar insurance
coverage elsewhere or that the cost thereof will not be prohibitively expensive.


ITEM 16. LIST OF EXHIBITS

              EXHIBIT NO.                 DESCRIPTION

                  5.1       Opinion of Morgan, Lewis & Bockius LLP
                  23.1      Consent of PricewaterhouseCoopers LLP
                  24.1      Power of attorney (included on the signature page)


ITEM 17. UNDERTAKINGS.

         The undersigned registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this registration statement;

         (i) To include any prospectus required by Section 10(a)(3) of the
Securities Act;

         (ii) To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement;

         (iii) To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;

         Provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if
the information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed with or furnished to the SEC
by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act
that are incorporated by reference in the registration statement.

         (2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.


II-2


         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act that is incorporated by reference in the registration statement
shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.

         Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions or otherwise, the registrant has
been advised that in the opinion of the SEC such indemnification is against
public policy as expressed in the Act and is, therefore, unenforceable. In the
event that a claim for indemnification against such liabilities (other than the
payment by us of expenses incurred or paid by a director, officer or person
controlling us in the successful defense of any action, suit or proceeding) is
asserted by such director, officer or controlling person in connection with the
securities being registered, we will unless in the opinion of counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, the information omitted from
the form of prospectus filed as part of this registration statement in reliance
upon Rule 430A and contained in a form of prospectus filed by the registrant
pursuant to Rule 424(b)(1) or (4) or 497(h) under the Securities Act shall be
deemed to be part of this registration statement as of the time it was declared
effective.




II-3


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Ann Arbor, State of Michigan, on October 10, 2003.

                                      ESPERION THERAPEUTICS, INC.

                                      By /s/ Roger S. Newton
                                         ---------------------
                                         Roger S. Newton
                                         President and Chief Executive Officer

         Pursuant to the requirements of the Securities Act, this registration
statement on Form S-3 has been signed by the following persons in the capacities
indicated on October 10, 2003. Each person whose individual signature appears
below hereby appoints Roger S. Newton, Timothy M. Mayleben and any other person
appointed as attorney-in-fact, or any of them, as his or her true and lawful
attorney-in-fact, with full power of substitution and resubstitution,` with the
authority to execute in the name of each such person and to file with the
Securities and Exchange Commission, together with any exhibits and other
documents, any and all amendments (including any post-effective amendments) to
this registration statement necessary or advisable to enable the registrant to
comply with the Securities Act and any rules, regulations and requirements of
the Securities and Exchange Commission in respect thereof, which amendments may
make such other changes in the registration statement as the aforesaid
attorney-in-fact executing the same deems appropriate.

           SIGNATURE                                 TITLE

     /s/ Roger S. Newton             President, Chief Executive Officer and
     -------------------
          Roger S. Newton            Director (Principal Executive Officer)

     /s/ Timothy M. Mayleben         Chief Operating Officer and Chief Financial
     -----------------------
          Timothy M. Mayleben        Officer (Principal Financial Officer)

     /s/ Frank E. Thomas             Vice President, Finance and Investor
     -------------------
          Frank E. Thomas            Relations (Principal Accounting Officer)

     /S/ Susan B. Bayh               Director
     -----------------
          Susan B. Bayh

     /s/ Henry E. Blair              Director
     ------------------
          Henry E. Blair

     /s/ Ronald M. Cresswell         Director
     -----------------------
          Ronald M. Cresswell

     /s/ Antonio M. Gotto, Jr.       Director
     -------------------------
          Antonio M. Gotto, Jr.

     /s/ Eileen M. More              Director
     ------------------
          Eileen M. More





II-4




                                INDEX TO EXHIBITS



      EXHIBIT NO.                     DESCRIPTION

          5.1             Opinion of Morgan, Lewis & Bockius LLP
          23.1            Consent of PricewaterhouseCoopers LLP
          24.1            Power of attorney (included on the signature page)