Edgar Filing: KERYX BIOPHARMACEUTICALS INC

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

SCHEDULE 14A
(RULE 14A-101)

INFORMATION REQUIRED IN PROXY STATEMENT

SCHEDULE 14A INFORMATION

PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
EXCHANGE ACT OF 1934

Filed by the Registrant [X]
Filed by a Party Other Than the Registrant [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement
[ ] Confidential, for Use of the Commission Only (as permitted by Rule
14a-6(e)(2))
[X] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to Section 240.14a-12

KERYX BIOPHARMACEUTICALS, INC.
(Name of Registrant as Specified in Its Charter)

Payment of Filing Fee (Check the appropriate box):

[X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

(1) Title of each class of securities to which transaction applies:

---------------------------------------------------------------
(2) Aggregate number of securities to which transaction applies:

---------------------------------------------------------------
(3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which
the filing fee is calculated and state how it was determined):

-----------------------------------------------------------------
(4) Proposed maximum aggregate value of transaction:

-----------------------------------------------------------------
(5) Total fee paid:

-----------------------------------------------------------------
[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by
Exchange Act Rule 0-11(a)(2) and identify the filing for which the
offsetting fee was paid previously. Identify the previous filing
by registration statement number, or the Form or Schedule and the
date of its filing.

(1) Amount previously paid:

-----------------------------------------------------------------
(2) Form, Schedule or Registration Statement No.:

-----------------------------------------------------------------
(3) Filing Party:

-----------------------------------------------------------------
(4) Date Filed:

-----------------------------------------------------------------

(KERYX LOGO)

KERYX BIOPHARMACEUTICALS, INC.
750 LEXINGTON AVENUE
NEW YORK, NEW YORK 10022

Dear Stockholder:

You are cordially invited to our 2004 Annual Meeting of Stockholders, to be
held at 10:00 a.m. local time, on June 10, 2004, at the offices of our legal
counsel, Alston & Bird LLP, located at 90 Park Avenue, New York, New York 10016.
At the meeting, the stockholders will be asked (i) to re-elect our seven current
directors to serve an additional one-year term on our Board of Directors, (ii)
to approve the issuance of up to approximately 3.4 million shares of our common
stock as milestone-based merger consideration for our recently completed
acquisition of ACCESS Oncology, Inc., (iii) to approve the 2004 Long-Term
Incentive Plan, (iv) to approve the delisting of our common stock from the
Alternative Investment Market of the London Stock Exchange, and (v) to amend our
certificate of incorporation to increase the number of authorized shares of our
common stock. You will also have the opportunity to ask questions and make
comments at the meeting. Enclosed with this letter are the following documents:
(1) the Notice of 2004 Annual Meeting of Stockholders, (2) our 2003 Annual
Report, and (3) our Proxy Statement and voting card.

It is important that your stock be represented at the meeting regardless of
the number of shares you hold. You are encouraged to specify your voting
preferences by so marking the enclosed proxy card or by voting electronically
using the Internet or by telephone. If you do attend the meeting and wish to
vote in person, you may revoke your proxy at the meeting.

If you have any questions about the Proxy Statement or the accompanying
2003 Annual Report, please contact Ron Bentsur at (212) 531-5965.

We look forward to seeing you at the 2004 Annual Meeting.

Sincerely,

/s/ Michael S. Weiss
Michael S. Weiss
Chairman and Chief Executive Officer

(KERYX LOGO)

KERYX BIOPHARMACEUTICALS, INC.
750 LEXINGTON AVENUE
NEW YORK, NEW YORK 10022
NOTICE OF 2004 ANNUAL MEETING OF STOCKHOLDERS
The 2004 Annual Meeting of Stockholders of Keryx Biopharmaceuticals, Inc.
will be held at the offices of our legal counsel, Alston & Bird LLP, located at
90 Park Avenue, New York, New York 10016, on Thursday, June 10, 2004, at 10:00
a.m., local time. At the meeting, stockholders will consider and act on the
following items:
1. The re-election of our seven current directors, each for an
additional term of one year;

2. The issuance of up to approximately 3.4 million shares of our
common stock as merger consideration, subject to the achievement of certain
milestones, in connection with our recently completed acquisition of ACCESS
Oncology, Inc.;

3. The approval of our 2004 Long-Term Incentive Plan;
4. The delisting of our common stock from the Alternative Investment
Market of the London Stock Exchange;
5. The amendment of our certificate of incorporation to increase the
number of authorized shares of our common stock; and
6. The transaction of any other business that may properly come before
the 2004 Annual Meeting or any adjournment of the 2004 Annual Meeting.
Only those stockholders of record as of the close of business on April 15,
2004 are entitled to vote at the 2004 Annual Meeting or any postponements or
adjournments of the 2004 Annual Meeting. A complete list of stockholders
entitled to vote at the 2004 Annual Meeting will be available for your
inspection beginning May 31, 2004, at our offices located at 750 Lexington
Avenue, New York, New York 10022, between the hours of 9:30 a.m. and 5:00 p.m.,
local time, each business day.
YOUR VOTE IS IMPORTANT!

You may vote your shares by completing and returning the enclosed proxy
card or you may vote electronically via the Internet or by telephone. Submitting
your proxy card does not affect your right to vote in person if you decide to
attend the 2004 Annual Meeting. You are urged to submit your proxy as soon as
possible, regardless of whether or not you expect to attend the 2004 Annual
Meeting. You may revoke your proxy at any time before its exercise at the 2004
Annual Meeting (i) by delivering written notice to the Company's Secretary, Ron
Bentsur, at the above address, (ii) by submitting a later dated proxy card, or
(iii) by attending the 2004 Annual Meeting to vote in person. No revocation
under clauses (i) or (ii) shall be effective until written notice is received by
the Secretary at or before the 2004 Annual Meeting.

When you submit your proxy card, you authorize Michael S. Weiss and Ron
Bentsur to vote your shares at the 2004 Annual Meeting in accordance with your
instructions, and to vote on any adjournments of the 2004 Annual Meeting.

By Order of the Board of Directors,

/s/ Ron Bentsur
Ron Bentsur
Secretary

April 29, 2004
New York, New York

KERYX BIOPHARMACEUTICALS, INC.
750 LEXINGTON AVENUE
NEW YORK, NEW YORK 10022
PHONE: (212) 531-5965
FAX: (212) 531-5961

PROXY STATEMENT

THIS PROXY STATEMENT AND THE ACCOMPANYING PROXY CARD ARE BEING MAILED,
BEGINNING ON OR ABOUT APRIL 29, 2004, TO THE OWNERS OF SHARES OF COMMON STOCK OF
KERYX BIOPHARMACEUTICALS, INC. (THE "COMPANY," "OUR," "WE," OR "KERYX") AS OF
APRIL 15, 2004, IN CONNECTION WITH THE SOLICITATION OF PROXIES BY OUR BOARD OF
DIRECTORS FOR OUR 2004 ANNUAL MEETING OF STOCKHOLDERS (THE "ANNUAL
MEETING"). The Annual Meeting will take place at the offices of our legal
counsel, Alston & Bird LLP, located at 90 Park Avenue, New York, New York 10016
on Thursday, June 10, 2004, at 10:00 a.m., local time. Our Board of Directors
encourages you to read this document thoroughly and take this opportunity to
vote, via proxy, on the matters to be decided at the Annual Meeting. As
discussed below, you may revoke your proxy at any time before your shares are
voted at the Annual Meeting.

TABLE OF CONTENTS

PROXY STATEMENT............................................. I
QUESTIONS AND ANSWERS....................................... 1
What is the purpose of the Annual Meeting?................ 1
Who is entitled to vote at our Annual Meeting?............ 1
How do I vote?............................................ 1
What is a proxy?.......................................... 1
How will my shares be voted if I vote by proxy?........... 1
How do I revoke my proxy?................................. 2
Is my vote confidential?.................................. 2
How are votes counted?.................................... 2
What constitutes a quorum at an Annual Meeting?........... 2
What vote is required to elect our new directors?......... 2
What vote is required to approve the issuance of our
common stock as merger consideration for our
acquisition of ACCESS Oncology?........................ 3
What will happen if we don't approve the issuance of our
common stock to the former stockholders of ACCESS
Oncology?.............................................. 3
What vote is required to approve and adopt the 2004
Long-Term Incentive Plan?.............................. 3
What vote is required to approve the delisting of our
common stock from the Alternative Investment Market of
the London Stock Exchange?............................. 3
What vote is required to amend our certificate of
incorporation to increase the number of authorized
shares of our common stock?............................ 3
What percentage of our outstanding common stock do our
directors and executive officers own?.................. 3
Who is our independent public accountant? Will they be
represented at the Annual Meeting?..................... 4
How can I obtain a copy of our annual report on Form
10-K?.................................................. 4
OUR BOARD OF DIRECTORS AND ITS COMMITTEES................... 5
Communicating with the Board of Directors................. 5
Audit Committee........................................... 5
Compensation Committee.................................... 6
Nominating Committee...................................... 6
DIRECTOR COMPENSATION....................................... 7
REPORT OF THE AUDIT COMMITTEE............................... 7
INDEPENDENT AUDITOR FEES AND OTHER MATTERS.................. 9
Audit Fees................................................ 9
Audit-Related Fees........................................ 9
Tax Fees.................................................. 9
All Other Fees............................................ 9
Pre-Approval of Services from KPMG........................ 9
OUR EXECUTIVE OFFICERS...................................... 10
Executive Officers........................................ 10
Employment Agreements..................................... 10
EXECUTIVE COMPENSATION...................................... 13
Summary Compensation Table................................ 13
Option Grants in Last Fiscal Year......................... 13
Aggregated Option/SAR Exercises in Fiscal Year 2003 and
Fiscal Year-End Option/SAR Values...................... 14
Equity Compensation Plan Information...................... 14

REPORT OF THE COMPENSATION COMMITTEE........................ 15
What is our compensation philosophy?...................... 15
What is the structure of our executive compensation?...... 15
How do we determine base salaries?........................ 15
How do we determine annual bonuses?....................... 15
How do we use compensation to ensure that our senior
management is focused on our long-term performance?.... 15
How do we determine the compensation of our Chief
Executive Officer?..................................... 16
What is the impact of Internal Revenue Code Section
162(m)?................................................ 16
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER
PARTICIPATION............................................. 16
COMMON STOCK PERFORMANCE GRAPH.............................. 17
SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE..... 18
RELATED-PARTY TRANSACTIONS.................................. 18
STOCK OWNERSHIP OF OUR DIRECTORS, EXECUTIVE OFFICERS, AND 5%
BENEFICIAL OWNERS......................................... 19
PROPOSAL ONE: ELECTION OF DIRECTORS; NOMINEES............... 20
Certain Information Concerning the Director Nominees...... 20
PROPOSAL TWO: ISSUANCE OF COMMON STOCK TO FORMER
STOCKHOLDERS OF ACCESS ONCOLOGY UPON ACHIEVEMENT OF
CERTAIN MILESTONES........................................ 22
Background of the Merger.................................. 22
The Merger Consideration.................................. 23
Interests of Certain Persons in Matters to be Acted
Upon................................................... 24
Registration and Listing with Nasdaq...................... 25
Financial and Other Information........................... 25
PROPOSAL THREE: APPROVAL OF THE 2004 LONG-TERM INCENTIVE
PLAN...................................................... 25
Summary of the 2004 Plan.................................. 26
Termination and Amendment................................. 29
Certain Federal Tax Effects............................... 29
PROPOSAL FOUR: APPROVAL OF THE DELISTING OF OUR COMMON STOCK
FROM THE ALTERNATIVE INVESTMENT MARKET OF THE LONDON STOCK
EXCHANGE.................................................. 31
PROPOSAL FIVE: APPROVAL OF AMENDMENT OF CERTIFICATE OF
INCORPORATION TO INCREASE AUTHORIZED COMMON STOCK......... 32
General................................................... 32
Purposes and Effects of the Amendment..................... 32
ADDITIONAL INFORMATION...................................... 33
Householding of Annual Meeting Materials.................. 33
Shareholder Proposals for our 2005 Annual Meeting......... 33
Other Matters............................................. 33
Solicitation of Proxies................................... 34
Incorporation of Information by Reference................. 34
ANNEX A -- FORM OF PROXY CARD............................... A-1
ANNEX B -- AMENDED AND RESTATED AUDIT COMMITTEE CHARTER..... B-1
ANNEX C -- 2004 LONG-TERM INCENTIVE PLAN.................... C-1

iii

QUESTIONS AND ANSWERS

Q. WHAT IS THE PURPOSE OF THE ANNUAL MEETING?

A. At the Annual Meeting, our stockholders will act upon the matters outlined
in the Notice of 2004 Annual Meeting of Stockholders accompanying this Proxy
Statement, including (i) the re-election of our seven current directors,
(ii) the issuance of up to approximately 3.4 million shares of our common
stock as merger consideration in connection with our recent acquisition of
ACCESS Oncology, Inc. ("ACCESS Oncology"), (iii) the approval of our 2004
Long-Term Incentive Plan, (iv) the approval of the delisting of our common
stock from the Alternative Investment Market of the London Stock Exchange,
and (v) the amendment of our certificate of incorporation to increase the
number of authorized shares of our common stock. We will also respond to
questions from stockholders.

Q. WHO IS ENTITLED TO VOTE AT OUR ANNUAL MEETING?

A. The record holders of our common stock at the close of business on the
record date, April 15, 2004, may vote at the Annual Meeting. Each share of
our common stock is entitled to one vote. There were 30,394,700 shares of
common stock outstanding on the record date and entitled to vote at the
Annual Meeting. A list of stockholders entitled to vote at the Annual
Meeting, including the address of and number of shares held by each
stockholder of record, will be available for your inspection beginning May
31, 2004, at our offices located at 750 Lexington Avenue, New York, New York
10022, between the hours of 9:30 a.m. and 5:00 p.m., local time, each
business day.

Q. HOW DO I VOTE?

A. You may vote by completing and returning the enclosed proxy card (attached
to this Proxy Statement as Annex A), by voting in person at the Annual
Meeting, or by voting electronically via the Internet at info@keryx.com or
by telephone. To vote by mail, simply mark, sign and date the enclosed proxy
card, and return it in the enclosed postage-paid envelope. Alternatively,
you may deliver your proxy card to us in person, by facsimile at (212)
531-5961 or by a courier at the address provided above. If you hold your
shares through a broker, bank, or other nominee, you will receive separate
instructions from the broker, bank, or nominee describing how to vote your
shares.

Q. WHAT IS A PROXY?

A. A proxy is a person you appoint to vote your shares on your behalf. If you
are unable to attend the Annual Meeting, our Board of Directors is seeking
your appointment of a proxy so that your shares of common stock may be
voted. You must complete and return the enclosed proxy card to vote by
proxy. If you vote by proxy, you will be designating Michael S. Weiss, our
Chief Executive Officer, and Ron Bentsur, our Vice President of Finance and
Investor Relations and Secretary, as your proxy. They may act on your behalf
and have the authority to appoint a substitute to act as proxy.

Q. HOW WILL MY SHARES BE VOTED IF I VOTE BY PROXY?

A. Your proxy will be voted according to the instructions provided on your
executed proxy card. IF YOU COMPLETE AND RETURN YOUR PROXY CARD BUT DO NOT
OTHERWISE PROVIDE INSTRUCTIONS, YOUR SHARES WILL BE VOTED (I) "FOR" THE
INDIVIDUALS NOMINATED TO SERVE AS DIRECTORS OF THE BOARD OF DIRECTORS, (II)
"FOR" THE ISSUANCE OF UP TO 3,372,422 SHARES OF OUR COMMON STOCK AS MERGER
CONSIDERATION IN CONNECTION WITH OUR RECENT ACQUISITION OF ACCESS ONCOLOGY,
(III) "FOR" THE APPROVAL OF OUR 2004 LONG-TERM INCENTIVE PLAN, (IV) "FOR"
THE APPROVAL OF THE DELISTING OF OUR COMMON STOCK FROM THE ALTERNATIVE
INVESTMENT MARKET, AND (V) "FOR" THE AMENDMENT OF OUR CERTIFICATE OF
INCORPORATION TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF OUR COMMON
STOCK. Presently, our Board of Directors does not know of any other matter
that may come before the Annual Meeting. However, your proxies are
authorized to vote on your behalf, using their discretion, on any other
business that properly comes before the Annual Meeting.

Q. HOW DO I REVOKE MY PROXY?

A. You may revoke your proxy at any time before your shares are voted at the
Annual Meeting by:

- notifying our Secretary, Ron Bentsur, in writing at 750 Lexington Avenue,
New York, New York 10022, that you are revoking your proxy;

- executing and returning to our Secretary, Ron Bentsur, a later dated
proxy card; or

- attending and voting by ballot at the Annual Meeting.

Q. IS MY VOTE CONFIDENTIAL?

A. Yes. All votes remain confidential, unless you indicate otherwise.

Q. HOW ARE VOTES COUNTED?

A. Before the Annual Meeting, our Board of Directors will appoint one or more
inspectors of election for the meeting. The inspectors will determine the
number of shares represented at the meeting, the existence of a quorum, and
the validity and effect of proxies. The inspectors also will receive, count,
and tabulate ballots and votes and determine the results of the voting on
each matter that comes before the Annual Meeting.

Abstentions and votes withheld, and shares represented by proxies reflecting
abstentions or votes withheld, will be considered as shares present and
entitled to vote at the Annual Meeting and will be counted as votes cast at
the Annual Meeting for quorum purposes. They will not be considered by the
inspectors of election as votes "for" or "against" any matter for which the
stockholder has indicated their intention to abstain or withhold their vote.
Broker or nominee non-votes, which occur when shares held in "street name"
by brokers or nominees who indicate on their proxies that they do not have
discretionary authority to vote on a particular matter, and shares
represented by proxies reflecting broker or nominee non-votes, will be
considered as not present and not entitled to vote on that subject matter
and therefore will not be considered by the inspectors of election when
counting votes cast on the matter. These shares will be considered entitled
to vote for quorum purposes and may be entitled to vote on other matter.

Q. WHAT CONSTITUTES A QUORUM AT THE ANNUAL MEETING?

A. In accordance with Delaware law (the law under which we are incorporated)
and our bylaws, the presence at the Annual Meeting, by proxy or in person,
of the holders of a majority of the shares of our common stock outstanding
on the record date constitutes a quorum, thereby permitting the stockholders
to conduct business at the Annual Meeting. Abstentions, votes withheld, and
broker or nominee non-votes, and shares represented by proxies reflecting
abstentions, votes withheld, or broker or nominee non-votes, will be
included in the calculation of the number of shares considered present at
the Annual Meeting for purposes of determining a quorum.

If a quorum is not present at the Annual Meeting, a majority of the
stockholders present in person and by proxy may adjourn the meeting to
another date. If an adjournment is for more than 30 days or a new record
date is fixed for the adjourned meeting, we will provide notice of the
adjourned meeting to each stockholder of record entitled to vote at the
adjourned meeting. At any adjourned meeting at which a quorum is present,
any business may be transacted that might have been transacted at the
originally called meeting.

Q. WHAT VOTE IS REQUIRED TO ELECT OUR NEW DIRECTORS?

A. The affirmative vote of a plurality of the votes of the shares present, in
person or by proxy, at the Annual Meeting is required for the election of
each of the nominees for director. Abstentions, votes withheld, and broker
or nominee non-votes, and shares represented by proxies reflecting
abstentions, votes withheld, or broker or nominee non-votes, will not affect
the outcome of director elections.

Q. WHAT VOTE IS REQUIRED TO APPROVE THE ISSUANCE OF OUR COMMON STOCK AS MERGER
CONSIDERATION FOR OUR ACQUISITION OF ACCESS ONCOLOGY?

A. The affirmative vote of a majority of the shares present, in person or by
proxy, and entitled to vote at the Annual Meeting is required to approve the
issuance of our common stock to the former stockholders of ACCESS Oncology
as merger consideration. Abstentions and votes withheld, and shares
represented by proxies reflecting abstentions or votes withheld, will have
the same effect as a negative vote. However, broker or nominee non-votes,
and shares represented by proxies reflecting broker or nominee non-votes,
will not have the effect of a vote against this proposal as they are not
considered to be present and entitled to vote on this matter.

Q. WHAT WILL HAPPEN IF WE DO NOT APPROVE THE ISSUANCE OF OUR COMMON STOCK TO
THE FORMER STOCKHOLDERS OF ACCESS ONCOLOGY?

A. The merger agreement we entered into with ACCESS Oncology obligates us to
issue fixed amounts of our common stock to the former ACCESS Oncology
stockholders when drug candidates of ACCESS Oncology achieve certain
development or revenue milestones or if we enter into certain strategic
transactions. If our stockholders do not approve the issuance of our common
stock to the former ACCESS Oncology stockholders, we will instead be
required to make cash payments to the former ACCESS Oncology stockholders
that have a value that is approximately equal to the value of the stock they
would have received upon the achievement of the milestone or the occurrence
of the strategic transaction.

Q. WHAT VOTE IS REQUIRED TO APPROVE AND ADOPT OUR 2004 LONG-TERM INCENTIVE
PLAN?

A. The affirmative vote of a majority of the shares present, in person or by
proxy, and entitled to vote at the Annual Meeting is required to approve and
adopt our 2004 Long-Term Incentive Plan. Abstentions and votes withheld, and
shares represented by proxies reflecting abstentions or votes withheld, will
have the same effect as a negative vote. However, broker or nominee
non-votes, and shares represented by proxies reflecting broker or nominee
non-votes, will not have the effect as a vote against this proposal as they
are not considered to be present and entitled to vote on this matter.

Q. WHAT VOTE IS REQUIRED TO APPROVE THE DELISTING OF OUR COMMON STOCK FROM THE
ALTERNATIVE INVESTMENT MARKET OF THE LONDON STOCK EXCHANGE?

A. The affirmative vote of 75% of the shares present, in person or by proxy,
and entitled to vote at the Annual Meeting is required to approve the
delisting of our common stock from the Alternative Investment Market of the
London Stock Exchange. Abstentions and votes withheld, and shares
represented by proxies reflecting abstentions or votes withheld, will have
the same effect as a negative vote. However, broker or nominee non-votes,
and shares represented by proxies reflecting broker or nominee non-votes,
will not have the effect as a vote against this proposal as they are not
considered to be present and entitled to vote on this matter.

Q. WHAT VOTE IS REQUIRED TO AMEND OUR CERTIFICATE OF INCORPORATION TO INCREASE
THE NUMBER OF AUTHORIZED SHARES OF OUR COMMON STOCK?

A. The affirmative vote of a majority of the shares present, in person or by
proxy, and entitled to vote at the Annual Meeting is required to approve the
amendment of our certificate of incorporation to increase the number of
authorized shares of our common stock. Abstentions and votes withheld, and
shares represented by proxies reflecting abstentions or votes withheld, will
have the same effect as a negative vote. However, broker or nominee
non-votes, and shares represented by proxies reflecting broker or nominee
non-votes, will not have the effect as a vote against this proposal.

Q. WHAT PERCENTAGE OF OUR OUTSTANDING COMMON STOCK DO OUR DIRECTORS AND
EXECUTIVE OFFICERS OWN?

A. As of December 31, 2003, our directors and executive officers owned
approximately 28.91% of our outstanding common stock. See the discussion
under the heading "Stock Ownership of Our Directors, Executive Officers, and
5% Beneficial Owners" on page 19 for more details.

Q. WHO IS OUR INDEPENDENT PUBLIC ACCOUNTANT? WILL THEY BE REPRESENTED AT THE
ANNUAL MEETING?

A. KPMG, our current auditor, has served as our independent public accountant
and auditor since 1999. Our Audit Committee has approved the retention of
KPMG to audit our financial statements for fiscal year 2004. We expect a
representative of KPMG to be present at the Annual Meeting. The
representative will have an opportunity to make a statement and will be
available to answer your questions.

Q. HOW CAN I OBTAIN A COPY OF OUR ANNUAL REPORT ON FORM 10-K?

A. We have filed our Annual Report on Form 10-K for the year ended December 31,
2003 with the Securities and Exchange Commission (the "SEC"). You may
obtain, free of charge, a copy of our Annual Report on Form 10-K, including
financial statements and financial statement schedules, by writing to our
Secretary, Ron Bentsur, at 750 Lexington Avenue, New York, New York 10022,
or via e-mail at info@keryx.com. Upon request, we will also furnish any
exhibits to the Annual Report on Form 10-K as filed with the SEC.

OUR BOARD OF DIRECTORS AND ITS COMMITTEES

Our Board of Directors consists of the following seven persons, additional
information about which is presented in connection with Proposal One: Election
of Directors; Nominees beginning on page 20 of this proxy statement.

NAME AGE POSITION DIRECTOR SINCE
---- --- -------- --------------

Michael S. Weiss.......................... 38 Chairman of the Board and 2002
Chief Executive Officer
I. Craig Henderson, M.D................... 62 President, Director 2004
Malcolm Hoenlein.......................... 60 Director 2001
Peter Morgan Kash......................... 42 Vice Chairman 1998
Lawrence Jay Kessel, M.D.................. 50 Director 2003
Lindsay A. Rosenwald, M.D................. 49 Director 2000
Peter Salomon, M.D........................ 44 Director 2003

Consistent with the new corporate governance standards applicable to
issuers listed on the Nasdaq National Market ("Nasdaq"), our Board of Directors
undertook its annual review of director independence on April 14, 2004. During
the review, our Board of Directors considered relationships and transactions
during 2004 and during the past three fiscal years between each director or any
member of his immediate family, on the one hand, and we and our subsidiaries and
affiliates, on the other hand. The purpose of this review was to determine
whether any such relationships or transactions were inconsistent with a
determination that the director is independent. Based on this review, our Board
of Directors determined that Messrs. Hoenlein, Kash, Kessel, Rosenwald and
Salomon are independent under the criteria established by Nasdaq and by our
Board of Directors.

During 2003, each incumbent director standing for re-election attended at
least 75% of the meetings of the Board of Directors and the meeting(s) of those
committees on which each incumbent director served, in each case during the
period that such person was a director. The current, permanent committees
established by our Board of Directors are the Audit Committee and the
Compensation Committee, descriptions of which are set forth in more detail
below. In addition, the directors are expected to attend each annual meeting of
stockholders and all directors attended the 2003 Annual Meeting of Stockholders.

COMMUNICATING WITH THE BOARD OF DIRECTORS

Our Board of Directors has established a process through which stockholders
can send communications to the Board of Directors. You may communicate with the
Board of Directors as a group, or to specific non-management directors, by
writing to our Secretary and Vice President of Finance and Investor Relations,
Ron Bentsur, at our offices located at 750 Lexington Avenue, New York, New York
10022. The Secretary will review all such correspondence and regularly forward
to the Board of Directors a summary of all such correspondence and copies of all
correspondence that, in the opinion of the Secretary, deals with the functions
of the Board or committees thereof or that he otherwise determines requires
their attention. Directors may at any time review a log of all correspondence we
receive that is addressed to members of our Board of Directors and request
copies of any such correspondence. Concerns relating to accounting, internal
controls, or auditing matters may be communicated in this manner, or may be
submitted on an anonymous basis via e-mail at the following e-mail address:
info@keryx.com. These concerns will be immediately brought to the attention of
our Audit Committee and handled in accordance with procedures established by the
Audit Committee with respect to such matters.

AUDIT COMMITTEE

The Audit Committee held five meetings during the fiscal year ended
December 31, 2003. The Audit Committee currently consists of Mr. Peter Kash, Dr.
Lawrence Kessel and Dr. Peter Salomon. The duties and responsibilities of the
Audit Committee are set forth in the amended and restated charter of the Audit
Committee adopted by the Board of Directors. A copy of the amended and restated
charter of the Audit Committee is attached to this proxy statement as Annex B.
(In addition, a copy of the amended and restated charter of the Audit

Committee can be found on our corporate website at www.keryx.com.). Among other
things, the duties and responsibilities of the Audit Committee include reviewing
and monitoring our financial statements and internal accounting procedures,
making recommendations to our Board of Directors regarding the selection of
independent accountants and consulting with and reviewing the services provided
by our independent accountants.

During the year, our Board of Directors examined the composition of the
Audit Committee in light of the current rules and regulations governing audit
committees, particularly the new Nasdaq corporate governance Rules and Rule
10A-(3)(b)(1) of the Securities Exchange Act of 1934, as amended (the "Exchange
Act"). Based upon this examination, our Board of Directors has determined that
all members of the Audit Committee are "independent," as required by Nasdaq and
set forth in the rules of the National Association of Securities Dealers (the
"NASD Rules"), specifically rules 4200(a)(15) and 4350(d)(2), and are otherwise
qualified members of our Audit Committee under the NASD Rules. The Board of
Directors has determined that Mr. Kash is an "audit committee financial expert,"
as the SEC defines that term. Please see Proposal One for a description of the
relevant experience of Mr. Kash.

The report of the Audit Committee can be found beginning on page 7 of this
proxy statement.

COMPENSATION COMMITTEE

The Compensation Committee held one meeting during the fiscal year ended
December 31, 2003 and took a number of other actions by unanimous written
consent. The Compensation Committee currently consists of Dr. Lindsay Rosenwald
and Mr. Malcolm Hoenlein. Among other things, the Compensation Committee
determines the compensation of our Chief Executive Officer and reviews and takes
action on the recommendation of our Chief Executive Officer as to the
appropriate compensation of our other executive officers. The Compensation
Committee is primarily responsible for the administration of our stock option
plans, under which option grants and stock issuances may be made to all
employees, directors and consultants. The Board of Directors has determined that
all members of the Compensation Committee are "independent," as that term is
defined in Rule 4200(a)(15) of the NASD Rules.

NOMINATING COMMITTEE

We do not currently have a nominating committee or any other committee
serving a similar function. Director nominations are recommended to the full
Board of Directors by a vote of a majority of our independent directors.
Although we do not have a written charter in place to select director nominees,
our Board of Directors has adopted resolutions authorizing a director nomination
process. We believe that the current process in place functions to select
director nominees who will be valuable members of our Board of Directors.

Our independent directors will consider candidates recommended by
stockholders for nomination to our Board of Directors. A stockholder who wishes
to recommend a candidate for nomination to our Board of Directors must submit
such recommendation to our Secretary, Ron Bentsur, at our offices located at 750
Lexington Avenue, New York, New York 10022. Such written recommendation must be
received not less than 120 calendar days nor more than 150 calendar days before
the first anniversary date of the proxy statement being released in connection
with the previous year's annual meeting. All stockholder recommendations of
candidates for nomination for election to our Board of Directors must be in
writing and must set forth as to each director candidate recommended the
following: (i) the candidate's name, age, business address, and other contact
information, (ii) a complete description of the candidate's qualifications,
experience, background and affiliations, as would be required to be disclosed in
the proxy statement pursuant to Regulation 14A of the SEC, (iii) a sworn or
certified statement by the candidate in which he or she consents to being named
in the proxy statement as a nominee and to serve as director if elected and (iv)
the name and address of the stockholder(s) of record making such a
recommendation.

Our independent directors evaluate candidates to our Board of Directors by
reviewing their biographical information and qualifications. If the independent
directors determine that a candidate is qualified to serve on our Board
Directors, such candidate is interviewed by at least one of the independent
directors and our Chief Executive Officer. Members of the Board also have an
opportunity to interview qualified candidates. The independent directors then
determine, based on the background information and the information obtained in

the interviews, whether to recommend to the Board of Directors that the
candidate be nominated for approval by the stockholders to fill a directorship.
With respect to an incumbent director whom the independent directors are
considering as a potential nominee for re-election, the independent directors
review and consider the incumbent director's service to us during his or her
term, including the number of meetings attended, level of participation, and
overall contribution to us in addition to such person's biographical information
and qualifications. The manner in which the independent directors evaluate a
potential nominee will not differ based on whether the candidate is recommended
by our directors or stockholders.

We consider the following qualifications, among others, when making a
determination as to whether a person should be nominated to our Board of
Directors: the independence of the director nominee; the nominees' character and
integrity, financial literacy, level of education and business experience;
whether the nominee has sufficient time to devote to our Board of Directors; and
the nominees commitment to represent the long-term interests of our
stockholders.

Our independent directors identify potential nominees for director through
a variety of business contacts, including current executive officers, directors,
community leaders and stockholders as a source for potential candidates. The
independent directors may, to the extent they deem appropriate, retain a
professional search firm and other advisors to identify potential nominees for
director.

DIRECTOR COMPENSATION

Directors who neither are employed by us nor have a contractual right to a
seat on our Board of Directors are entitled to the following compensation:

- Each director receives reimbursement for reasonable travel expenses
incurred in attending meetings of our Board of Directors and meetings of
committees of our Board of Directors.

- Upon initial election or appointment to our Board of Directors, each
director is entitled to receive an option to purchase 25,000 shares of
our common stock pursuant to our 2000 Stock Option Plan. Upon each
re-election to our Board of Directors, each director receives an option
to purchase an additional 5,000 shares of our common stock. These options
are granted to each director on the next business day after the
adjournment of the annual meeting of stockholders. Under United States
federal income tax law, these options are non-qualified stock options.
Pursuant to the 2000 Stock Option Plan, each option grant has an exercise
price per share equal to the fair market value of our common stock on the
date of grant and a portion of such grant may be immediately exercisable.
Each grant has a term of ten years, subject to earlier termination
following the director's cessation of service on our Board of Directors.

- Mr. Peter Kash receives an annual stipend of $60,000, solely as
compensation for his work as a non-employee director and Vice Chairman of
our Board of Directors.

REPORT OF THE AUDIT COMMITTEE

The following report of the Audit Committee does not constitute soliciting
material and should not be deemed filed or incorporated by reference into any
other filing we make under the Securities Act of 1933, as amended (the
"Securities Act"), or the Exchange Act, except to the extent we specifically
incorporate this report by reference therein.

In March 2004, our Audit Committee reviewed its written charter previously
adopted by our Board of Directors in light of the new corporate governance rules
established by Nasdaq and the SEC. Following this review, our Board of Directors
adopted an amended and restated charter for our Audit Committee, a copy of which
is attached to this proxy statement as Annex B.

As discussed more fully in the amended and restated charter, the Audit
Committee's primary responsibilities fall into three broad categories:

- First, the Audit Committee is charged with monitoring the preparation of
quarterly and annual financial statements by our management, including
discussions with management and our outside auditor about the preparation
of the statements and key accounting, reporting and disclosure matters;

- Second, the Audit Committee is responsible for monitoring our
relationship with our outside auditor, including controlling the
appointment, retention, compensation and evaluation of the auditor,
reviewing the scope of audit and permissible non-audit services and
related fees (including any other services being provided to us by the
auditor), and determining whether the outside auditor is independent; and

- Third, the Audit Committee oversees management's implementation of
effective systems of internal controls, including the review of policies
relating to legal and regulatory compliance, ethics, and conflicts of
interests, and review of the activities and recommendations of our
internal auditing program.

The Audit Committee has implemented procedures to ensure that during the
course of each fiscal year it devotes appropriate attention to each of the
matters assigned to it under its amended and restated charter.

In monitoring the preparation of our financial statements, the Audit
Committee met with both management and our outside auditors to review and
discuss all financial statements prior to their issuance and to discuss any and
all significant accounting issues. Management and our auditor advised the Audit
Committee that each of the financial statements were prepared in accordance with
generally accepted accounting principles. The Audit Committee's review included
a discussion of the matters required to be discussed pursuant to the Statement
on Auditing Standards No. 61, "Codification of Statements on Auditing
Standards," as amended ("SAS 61"). SAS 61 requires our independent auditor to
discuss with the Audit Committee, among other things, the following:

- Methods used to account for significant or unusual transactions;

- The effect of any accounting policies in controversial or emerging areas
for which there is a lack of authoritative guidance or consensus;

- The process used by management to formulate sensitive accounting
estimates and the basis for the auditor's conclusion regarding the
reasonableness of any such estimates; and

- Any disagreements with management over the application of accounting
principals, the basis for management's accounting estimates and the
disclosures necessary in the financial statements.

With respect to our outside auditor, the Audit Committee, among other
things, discussed with KPMG its independence, including the written disclosures
made by KPMG to the Audit Committee as required by the Independence Standards
Board Standard No. 1, "Independence Discussions with Audit Committees."
Independence Standards Board Standard No. 1 requires auditors to (i) disclose in
writing all relationships that in the auditors' professional opinion may
reasonably be thought to bear on independence, (ii) confirm their perceived
independence, and (iii) engage in a discussion of independence with the Audit
Committee.

Finally, the Audit Committee continued to monitor the scope and adequacy of
our internal controls and other procedures, including any and all proposals for
adequate staffing and for strengthening internal procedures and controls where
appropriate and necessary.

On the basis of these reviews and discussions, the Audit Committee
recommended to the Board of Directors that it approve the inclusion of our
audited financial statements in our Annual Report on Form 10-K for the fiscal
year ended December 31, 2003, for filing with the SEC.

By the Audit Committee of the Board of
Directors

Mr. Peter Morgan Kash, Chairman

Dr. Lawrence Jay Kessel

Dr. Peter Salomon

INDEPENDENT AUDITOR FEES AND OTHER MATTERS

KPMG LLP has audited our financial statements for the fiscal years ended
December 31, 2002 and December 31, 2003. The Audit Committee has reviewed the
fees described below and concluded that the payment of such fees is compatible
with maintaining KPMG's independence. All proposed engagements of KPMG, whether
for audit services or permissible non-audit services, are pre-approved by the
Audit Committee.

AUDIT FEES

During the fiscal years ended December 31, 2002 and December 31, 2003, KPMG
billed us an aggregate of approximately $120,300 and $107,900, respectively, in
fees for the professional services rendered in connection with the audits of our
annual financial statements included in our Annual Reports on Form 10-K for
those two fiscal years, and the review of our financial statements included in
our Quarterly Reports on Form 10-Q during those two fiscal years.

AUDIT-RELATED FEES

During the fiscal years ended December 31, 2002 and December 31, 2003, KPMG
billed us an aggregate of approximately $0 and $27,900, respectively, for
assurance and related services reasonably related to the performance of the
audits and reviews for those two fiscal years, in addition to the fees described
above under the heading "Audit Fees." These services included consultation in
connection with non-cash stock compensation, the restructuring of our operations
and our registration statement filings.

TAX FEES

During the fiscal years ended December 31, 2002 and December 31, 2003, KPMG
billed us an aggregate of approximately $73,700 and $35,400, respectively, for
professional services rendered for tax compliance, tax advice, and tax planning
services. These professional services consisted of general consultation from
time to time regarding compliance with and planning for federal, state, local,
and international tax matters.

ALL OTHER FEES

During the fiscal years ended December 31, 2002 and December 31, 2003, KPMG
billed us an aggregate of approximately $11,000 and $11,100, respectively, in
fees for services, other than those described above, rendered to us and our
affiliates for those two fiscal years. These fees were incurred for consulting
services on various issues, including primarily the structuring of potential
licensing arrangements and non-cash stock compensation.

PRE-APPROVAL OF SERVICES FROM KPMG

Since May 6, 2003, all services provided to us by KPMG have been required
by SEC rules implementing the Sarbanes-Oxley Act of 2002 to be approved by the
Audit Committee before KPMG commences performance of those services. In
preparation for these rules taking effect, the Audit Committee established a
policy setting forth procedures for KPMG, in cooperation with our management, to
seek pre-approval to provide services to us. The potential services that might
be provided by KPMG fall into three classifications:

- Services that are permitted by the Audit Committee, including the audit
and review of our annual and quarterly financial statements and related
attestations, pension and benefit plan audits and similar audit reports,
financial and other due diligence on acquisitions, and federal, state,
and non-US tax services;

- Services that may be permitted by the Audit Committee, subject to
individual pre-approval, including compliance and internal-control
reviews, indirect tax services such as transfer pricing and customs and
duties, certain human resources services, and forensic auditing; and

- Services that KPMG, as our independent auditor, may not legally provide,
such as bookkeeping, internal audit outsourcing, and investment advising
or investment banking.

All proposed engagements of KPMG, whether for audit services or permissible
non-audit services, are pre-approved by the Audit Committee. We jointly prepare
a schedule with KPMG that outlines services that we reasonably expect to need
from KPMG, and categorize them according to the classifications described above.
Each service identified is reviewed and approved or rejected by the Audit
Committee.

OUR EXECUTIVE OFFICERS

EXECUTIVE OFFICERS

Our executive officers are as follows:

NAME AGE POSITION
---- --- --------

Michael S. Weiss.......................... 38 Chairman and Chief Executive Officer
I. Craig Henderson, M.D................... 62 President
Ron Bentsur............................... 38 Vice President Finance and Investor
Relations

The following is information about our executive officers who are not also
directors. No executive officer is related by blood, marriage or adoption to any
other director or executive officer.

RON BENTSUR, 38, has served as our Vice President of Finance and Investor
Relations since June 2003. From October 2000 to June 2003, Mr. Bentsur served as
our Director of Investor Relations. From July 1998 to October 2000, he served as
Director of Technology Investment Banking at Leumi Underwriters, where he was
responsible for all technology/biotechnology private placement and advisory
transactions. From June 1994 to July 1998, Mr. Bentsur worked as an investment
banker at ING Barings Furman Selz. Mr. Bentsur holds a B.A. in Economics and
Business Administration with distinction from the Hebrew University of
Jerusalem, Israel and an M.B.A. from New York University's Stern Graduate School
of Business.

EMPLOYMENT AGREEMENTS

The following is a summary of the employment agreements with each of our
named executive officers.

MICHAEL S. WEISS

We entered into an employment agreement with Michael S. Weiss, dated as of
December 23, 2002, to serve as our Chairman and Chief Executive Officer. The
agreement provides that his initial base salary would be $250,000, with annual
salary increases to be determined at the sole discretion of our Board of
Directors. Mr. Weiss is also eligible to receive an annual bonus of up to 100%
of his base salary if certain corporate goals and objectives set by our Board of
Directors are met to the satisfaction of the Board of Directors. Mr. Weiss is
also eligible for additional performance-based cash bonuses as follows: (i) $1
million if our total market capitalization is greater than $500 million or our
working capital is at least $100 million, and (ii) $2 million if our total
market capitalization is greater than $1 billion or our working capital is at
least $150 million.

In order to induce Mr. Weiss to enter into an employment arrangement with
us, our Board of Directors granted Mr. Weiss an initial ten-year option to
purchase 4,050,000 shares of our common stock at an exercise price of $1.30 per
share, the fair market value of our common stock on the date of grant. This
option vests as follows:

- 1,350,000 shares of our common stock over the first three years of
employment, with 450,000 shares vesting at the end of the first year and
an additional 112,500 shares vesting quarterly thereafter;

- 1,350,000 shares of our common stock after seven years of employment,
provided that Mr. Weiss is employed on that date as our Chairman and/or
Chief Executive Officer and/or a member of our Board of Directors. These
options shall be accelerated upon the occurrence of the earlier of our:

- achieving a total market valuation of more than $500 million (including
shares held by affiliates); or

- obtaining at least $100 million in working capital.

- achieving a total market valuation of more than $1 billion (including
shares of our common stock held by affiliates); or

- obtaining at least $150 million in working capital.

The Board of Directors may, in its discretion, provide Mr. Weiss with
additional annual or special grants of stock options.

These options are intended to qualify as "incentive stock options" under
Section 422 of the Internal Revenue Code of 1986, as amended, to the extent
allowable. In the event of a change of control or a reorganization event, or in
the event that we terminate Mr. Weiss' employment, either without cause, or as a
result of his death or disability, or he terminates his employment for good
reason, the options described above that are unexercisable at the time of such
event or termination shall be accelerated and the time period during which he
shall be allowed to exercise such options shall be extended to the shorter of
two years from the date of the termination of his employment or December 24,
2012. Additionally, our Board of Directors shall have the discretion to
accelerate all or a portion of these options at any time.

The agreement may be terminated by either party for any reason on 90 days
notice. If we terminate Mr. Weiss without cause (as defined in the employment
agreement), or he terminates the agreement for good reason (as defined in the
employment agreement) and he signs a waiver and release of any claims against
us, he shall be entitled to receive a severance payment equal to 12 months of
his base salary and a pro-rata payment of the bonus he would have been entitled
to had he remained employed by us. Additionally, the occurrence of certain
events, such as a change in control (as defined in the employment agreement),
will cause the acceleration of certain unvested options held by Mr. Weiss. If he
is not re-elected to our Board of Directors at our 2004 Annual Meeting, he will
be entitled to terminate this employment agreement for good cause. The agreement
also provides that if Mr. Weiss's employment is terminated because of his death
or disability, he or his heirs will be paid his current salary for three months.

RON BENTSUR

We entered into an employment agreement with Ron Bentsur, dated June 23,
2003, to serve as our Vice President, Finance & Investor Relations. The
agreement provides that his initial base salary would be $160,000, with annual
salary increases to be determined at the discretion of the Board of Directors,
except that his salary will increase to $170,000 one year after the effective
date of his employment. Mr. Bentsur is also eligible to receive one or more
bonuses per calendar year in an amount determined at the discretion of the Chief
Executive Officer in consultation with our Board of Directors.

This employment agreement may be terminated by us or Mr. Bentsur for any
reason by providing 90 days written notice. If Mr. Bentsur is terminated within
the first nine months following the effective date of the employment agreement,
we will pay him his full salary and benefits until one year following the
effective date of his employment agreement. If Mr. Bentsur is terminated without
cause and signs a waiver and release of claims against us, our Board of
Directors will take all necessary steps to ensure the vesting of all of Mr.
Bentsur's unvested options. The employment agreement also provides that should
his employment be terminated due to disability or death, his heirs will be paid
his base salary for three months.

I. CRAIG HENDERSON, M.D.

We entered into an employment agreement with Dr. I. Craig Henderson, dated
as of January 31, 2004, to serve as our President. The agreement provides that
his initial base salary would be $250,000, with annual salary increases in
accordance with our corporate policies, but in no year should a salary increase
be less than the consumer price index announced for the previous calendar year.
Dr. Henderson is also eligible to receive an annual bonus up to 50% of his base
salary if certain performance objectives set by our Chief Executive Officer are
met.

In order to induce Dr. Henderson to enter into an employment arrangement
with us, our Board of Directors granted him an initial ten-year option to
purchase 1,000,000 shares of our common stock at an exercise price equal to the
closing price of our common stock on the trading day prior to the start of Dr.
Henderson's employment. The options vest as follows:

- 166,667 shares of our common stock over the first three years of
employment, with 55,556 shares vesting at the end of the first year and
an additional 13,889 shares vesting quarterly thereafter.

- 833,333 shares of our common stock after seven years of employment
provided that Dr. Henderson is employed on that date as our President.
The vesting of these options shall be accelerated in full upon the
occurrence of each of the following events:

- 166,667 shares of our common stock upon our achieving a total market
valuation of more than $500 million or obtaining at least $100
million in working capital;

- 166,666 shares of our common stock upon our achieving a total market
valuation of more than one billion or obtaining at least $150
million in working capital;

- 166,667 shares of our common stock upon the approval of a New Drug
Application ("NDA") for KRX-101 by the United States Food and Drug
Administration (the "FDA");

- 166,667 shares of our common stock upon the approval of the first
NDA by the FDA for a drug candidate acquired by us from ACCESS
Oncology; and

- 166,666 shares of our common stock upon annual sales for any or all
drug candidates acquired by us from ACCESS Oncology exceeding $100
million.

Dr. Henderson's employment agreement terminates on January 31, 2007 unless
either party terminates it at an earlier time. Additionally, the employment
agreement will be automatically renewed for two years unless either party
provides written notice of non-renewal to the other party at least six months
before the expiration date. If Dr. Henderson is terminated without just cause
(as defined in the employment agreement) or if Dr. Henderson terminates for good
reason (as defined in the employment agreement), he will receive (i) one year of
base salary, (ii) any unpaid portion of his bonus, and (iii) any incurred and
unpaid expenses. If Dr. Henderson's employment is terminated in anticipation of
or within 12 months following a qualified change in control (as defined in the
employment agreement), he will be paid two years of base salary. Certain of Dr.
Henderson's options will vest upon the occurrence of his termination. The
employment agreement also provides that should his employment be terminated as a
result of death of disability, Dr. Henderson's heirs would be paid his base
salary through the date of termination.

Dr. Henderson was initially appointed to our Board of Directors pursuant to
the employment agreement. If he is not re-elected to our Board of Directors at
our 2004 Annual Meeting, he will be entitled to terminate this employment
agreement for good reason.

EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

The following table sets forth the cash and other compensation we paid to
our named executive officers for all services in all capacities during the years
indicated.

ANNUAL COMPENSATION LONG-TERM COMPENSATION AWARDS
----------------------------------- ----------------------------------------
RESTRICTED SECURITIES
OTHER ANNUAL STOCK UNDERLYING ALL OTHER
NAME AND COMPENSATION AWARD(S) OPTIONS/SARS COMPENSATION
PRINCIPAL POSITION YEAR SALARY($) BONUS($) ($)(5) ($) (#) ($)(6)
------------------ ---- --------- -------- ------------ ---------- ------------ ------------

Michael S. Weiss.................... 2003 $250,000 $250,000 -- -- -- $14,462
Chairman and Chief 2002 $ 6,076 -- -- -- 4,050,000 --
Executive Officer(1) 2001 -- -- -- -- -- --
Ron Bentsur......................... 2003 $114,967 $ 35,000 $ 20,306 -- 170,000 $16,900
VP of Finance and 2002 $ 88,169 -- $ 23,721 -- 30,000 $12,000
Investor Relations(2) 2001 $ 83,004 $ 15,000 $ 19,669 -- 14,004 $ 6,500
Bob Trachtenberg.................... 2003 $ 91,125 -- $ 46,017 -- -- $11,569
Former General 2002 $129,375 -- $ 31,333 -- -- $15,123
Counsel(3) 2001 $100,000 $ 27,000 $ 24,009 -- 40,500 --
Ira Weinstein....................... 2003 $ 60,750 -- $ 77,105 -- -- $ 7,500
Former Interim Chief 2002 $129,375 -- $ 32,617 -- -- $15,056
Financial Officer(4) 2001 $ 99,000 $ 30,000 $ 33,541 -- 40,500 --

---------------

(1) Michael S. Weiss commenced serving as our Chairman and Chief Executive
Officer on December 23, 2002.

(2) Ron Bentsur commenced serving as our Vice President of Finance and Investor
Relations on June 23, 2003.

(3) Bob Trachtenberg's employment with us was terminated on September 30, 2003.

(4) Ira Weinstein's employment with us was terminated on June 30, 2003.

(5) Includes payments made for social security, pension and disability insurance
premiums, payments made in lieu of statutory severance, payments for
continuing education plans, and accrued vacation redemptions.

(6) Includes payments made for vacation accrual and reimbursement for automobile
and relocation expenses.

OPTION GRANTS IN LAST FISCAL YEAR

The following table provides certain information concerning individual
grants of options to purchase our common stock made to the named executive
officers during 2003 and the potential realizable value of those options as
determined in accordance with SEC rules.

INDIVIDUAL GRANTS
---------------------------------------------------------------------------
NUMBER OF PERCENT OF
SECURITIES TOTAL OPTIONS/
UNDERLYING SARS GRANTED EXERCISE OF
OPTIONS/SARS TO EMPLOYEES BASE PRICE EXPIRATION GRANT DATE
NAME GRANTED (#) IN FISCAL YEAR ($/SHARE) DATE PRESENT VALUE($)
---- ------------ -------------- ----------- ---------- ----------------

Michael S. Weiss.............. 0 0% -- -- --
Ron Bentsur................... 170,000 16.9% $1.10 7/1/2013 $113,390
Bob Trachtenberg.............. 0 0% -- -- --
Ira Weinstein................. 0 0% -- -- --

AGGREGATED OPTION/SAR EXERCISES IN FISCAL YEAR 2003 AND FISCAL YEAR END
OPTION/SAR VALUES

The following table provides certain information on options exercised by
the named executive officers during fiscal 2003 and unexercised options held as
of December 31, 2003.

NUMBER OF SECURITIES VALUE OF UNEXERCISED
UNDERLYING UNEXERCISED IN-THE-MONEY OPTIONS/SARS
SHARES OPTIONS/SARS AT FY-END(#) AT FY-END($)(1)
ACQUIRED ON VALUE --------------------------- ---------------------------
NAME EXERCISE REALIZED EXERCISABLE UNEXERCISABLE EXERCISABLE UNEXERCISABLE
---- ----------- -------- ----------- ------------- ----------- -------------

Michael S. Weiss...... 0 $ 0 450,000 3,600,000 $1,507,500 $12,060,000
Ron Bentsur........... 0 $ 0 81,336 174,668 $ 99,000 $ 603,500
Bob Trachtenberg...... 40,000 $193,200 358,120 0 $1,445,171 $ 0
Ira Weinstein......... 190,000 $615,600 245,620 0 $ 933,296 $ 0

---------------

(1) The value of the unexercised in-the-money options at year-end has been
calculated based on a price of $4.65, which was the closing sales price of
our common stock on Nasdaq on December 31, 2003.

EQUITY COMPENSATION PLAN INFORMATION

The following table shows aggregate information, as of December 31, 2003,
with respect to equity compensation plans under which shares of our common stock
are authorized for issuance.

(A) (B) (C)
NUMBER OF SECURITIES WEIGHTED-AVERAGE NUMBER OF SECURITIES REMAINING
TO BE ISSUED UPON EXERCISE PRICE AVAILABLE FOR FUTURE ISSUANCE
EXERCISE OF OF OUTSTANDING UNDER EQUITY COMPENSATION
OUTSTANDING OPTIONS, OPTIONS, WARRANTS PLANS (EXCLUDING SECURITIES
PLAN CATEGORY WARRANTS AND RIGHTS AND RIGHTS REFLECTED IN COLUMN (A))
------------- -------------------- -------------------- ------------------------------

Equity Compensation Plans
Approved by Security
Holders(1)................... 5,806,652 $1.50 1,237,522(3)
Equity Compensation Plans Not
Approved by Security
Holders(2)...................... 3,440,034 $2.13 22,500
TOTAL............................. 9,246,686 $1.73 1,260,072(3)

---------------

(1) Includes shares of our common stock available for future grants under the
1999 Plan and the 2000 Plan. No additional shares of our common stock may be
issued under the 1999 Plan and up to 1,237,522 shares may be issued under
the 2000 Plan as options or restricted stock. If the 2004 Long-Term
Incentive Plan had been approved by stockholders as of December 31, 2003, up
to 4,000,000 shares would be issuable under the 2004 Long-Term Incentive
Plan as options or restricted stock. See Proposal Three: Approval of the
2004 Long-Term Incentive Plan.

(2) Includes shares of our common stock available for future grants under the
Non-Plan and the 2002 CEO Incentive Plan. Up to 22,500 shares of our common
stock may be issued under the Non-Plan as options or restricted stock and no
additional shares may be issued under the 2002 CEO Incentive Plan.

(3) Does not include options to purchase 150,000 shares of our common stock
granted to two non-employee directors in June 2003. Such shares of our
common stock, when such options are exercised, will be issued under the 2004
Long-Term Incentive Plan, if approved by our shareholders. See Proposal
Three: Approval of the 2004 Long-Term Incentive Plan.

REPORT OF THE COMPENSATION COMMITTEE

The following report of the Compensation Committee does not constitute
soliciting material and should not be deemed filed or incorporated by reference
into any other filing we make under the Securities Act or the Exchange Act,
except to the extent we specifically incorporate this report or the performance
graphs by reference therein.

WHAT IS OUR COMPENSATION PHILOSOPHY?

Our philosophy is to provide competitive compensation packages and, where
appropriate, align compensation of senior management with the long-term
interests of our stockholders. We determine the compensation of our senior
management team by evaluating our corporate performance and each executive
officers' own level of performance.

WHAT IS THE STRUCTURE OF OUR EXECUTIVE COMPENSATION?

Executive compensation consists of a base salary, an annual cash bonus, and
annual long-term stock-based incentives.

We structure our compensation plans to provide incentives to our senior
management that will promote improvements in our corporate performance and stock
price over the short and long term.

HOW DO WE DETERMINE BASE SALARIES?

The Compensation Committee, along with our Chief Executive Officer, reviews
and approves an annual salary plan for our executive officers. Many subjective
factors are included in determining the executive's base salary, including:

- the executive officer's responsibilities;

- the scope of the executive officer's position;

- the experience and length of service with our organization;

- the individual efforts and performance within our organization and the
industry;

- the observance of our ethics and compliance program; and

- the salaries paid by competitive companies to officers in similar
positions.

HOW DO WE DETERMINE ANNUAL BONUSES?

We base each executive officer's annual bonus on a combination of our
overall performance (including, but not limited to, our stock price and our
overall financial performance) and the officer's overall performance.

HOW DO WE USE COMPENSATION TO ENSURE THAT OUR SENIOR MANAGEMENT IS FOCUSED ON
OUR LONG-TERM PERFORMANCE?

We use stock options to provide long-term incentives to our executive
officers. Generally, the Compensation Committee approves all grants of stock
options to executive officers. These stock option grants are designed to align
the interests of each executive officer with those of our stockholders. Options
are generally exercisable over a ten-year period at the fair market value per
share on the date of grant. Options granted to executive officers and others
pursuant to our 2000 Stock Option Plan generally become exercisable in equal
installments over a three-year vesting period. The options will provide an
economic benefit to the executive officer only if he or she remains employed by
us during the vesting period and the market price of our common stock increases.

HOW DO WE DETERMINE THE COMPENSATION OF OUR CHIEF EXECUTIVE OFFICER?

Mr. Weiss has been our Chief Executive Officer since December 23, 2002. For
the fiscal year ending December 31, 2003, the Compensation Committee set Mr.
Weiss' base salary at $250,000. The compensation level established in the
employment contract for Mr. Weiss was in response to the Compensation
Committee's and the Board's assessments of:

- our performance and accomplishments in the fiscal year ended December 31,
2002;

- the position of Mr. Weiss in our organization and the nature of his
responsibilities and contributions;

- the performance of Mr. Weiss in terms of our success in meeting certain
individual and performance targets, from both an operational and a
financial standpoint, and in executing our strategic plan; and

- our performance relative to our peers and competitors in the
biotechnology industry.

WHAT IS THE IMPACT OF INTERNAL REVENUE CODE SECTION 162(M)?

Section 162(m) of the Internal Revenue Code of 1986, as amended (the
"Internal Revenue Code"), generally disallows a tax deduction to public
companies for certain compensation in excess of one million dollars paid to our
executive officers. Certain compensation, including qualified performance-based
compensation, will not be subject to the deduction limit if certain requirements
are met. Our Compensation Committee reviews the potential effect of Section
162(m) of the Internal Revenue Code periodically and generally seeks to
structure the long-term incentive compensation granted to our executive officers
in a manner that is intended to avoid disallowance of deductions under Section
162(m) of the Internal Revenue Code. Nevertheless, there can be no assurance
that compensation attributable to awards granted under our option plans will be
treated as qualified performance-based compensation under Section 162(m) of the
Internal Revenue Code. In addition, our Compensation Committee reserves the
right to use its judgment to authorize compensation payments that may be subject
to the limit when it believes such payments are appropriate and in the best
interests of our stockholders, after taking into consideration changing business
conditions and the performance of our employees. For example, the Compensation
Committee has determined to grant our Chief Executive Officer an award of stock
options pursuant to the 2002 CEO Incentive Stock Option Plan that may be subject
to the limits because such plan has not been approved by our stockholders.

By the Compensation Committee of the
Board of Directors

Dr. Lindsay A. Rosenwald

Mr. Malcolm Hoenlein

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

The current members of our Compensation Committee are Dr. Lindsay A.
Rosenwald and Mr. Malcolm Hoenlein. No member of our Compensation Committee was
at any time during 2003, or formerly, an officer or employee of us or any of our
subsidiaries, nor has any other member of our Compensation Committee had any
relationship with us requiring disclosure under Item 404 of Regulation S-K under
the Exchange Act.

During the last fiscal year, none of our executive officers served as a
director or member of the compensation committee (or other committee serving an
equivalent function) of any other entity, whose executive officers either served
as a member of our Compensation Committee or our Board of Directors.

COMMON STOCK PERFORMANCE GRAPH

Our common stock has been listed for trading on the Nasdaq National Market
under the symbol "KERX" since July 28, 2000. The following graph compares the
cumulative total stockholder return on our common stock for the period from July
28, 2000, the date of our initial public offering, through December 31, 2003,
with the cumulative total return over such period on (i) the Nasdaq National
Market-US Index and (ii) the Nasdaq Stock Market-Biotechnology Index. The graph
assumes an investment of $100 on July 28, 2000 in our common stock (at the
initial offering price) and in each of the indices listed above, and assumes the
reinvestment of all dividends. Measurement points are July 28, 2000, December
31, 2000, December 31, 2001, December 31, 2002, and December 31, 2003.

(COMMON STOCK PERFORMANCE GRAPH)

CUMULATIVE TOTAL RETURN
------------------------------------------
7/00 12/00 12/01 12/02 12/03
------ ------ ------ ------ ------

KERYX BIOPHARMACEUTICALS, INC. ................... 100.00 101.25 73.00 15.80 46.50
NASDAQ STOCK MARKET (U.S.)........................ 100.00 66.64 50.05 35.35 54.03
NASDAQ BIOTECHNOLOGY.............................. 100.00 100.15 84.21 51.59 75.59

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section 16(a) of the Exchange Act requires our directors, executive
officers and persons who own more than 10% of the shares of our common stock to
file reports of ownership on Form 3 and changes in ownership on Form 4 or Form 5
with the SEC. Such officers, directors and 10% stockholders are also required by
SEC rules to furnish us with copies of all Section 16(a) reports of stock
ownership and changes in stock ownership forms that they file. The SEC rules
require us to disclose late filings of reports of stock ownership (and changes
in stock ownership) by our directors, executive officers and 10% stockholders.

Based solely on a review of copies of the Forms 3, 4 and 5 that we received
by the Company or representations from certain reporting persons, we believe
that during the fiscal year ended December 31, 2003, all Section 16(a) filing
requirements applicable to our directors, executive officers and 10%
stockholders were complied with in a timely manner.

RELATED-PARTY TRANSACTIONS

On February 1, 2003, we entered into an agreement with ACCESS Oncology, now
one of our subsidiaries, pursuant to which ACCESS Oncology has agreed to provide
us with office space and certain facility-related services at its offices
located at 750 Lexington Avenue, New York, New York 10022. Under the terms of
this agreement, we agreed to pay 75% of the rent and facility-related service
fees incurred by ACCESS Oncology for such office space. This percentage was
increased to 90% on June 1, 2003. As of March 31, 2004, we have paid ACCESS
Oncology approximately $254,124 pursuant to the terms of this agreement. Michael
S. Weiss, our Chairman and Chief Executive Officer, was a founder and former
executive officer of ACCESS Oncology, was the single largest stockholder of
ACCESS Oncology, and was a member of the board of directors of ACCESS Oncology.
Lindsay A. Rosenwald, one of our directors, held significant amounts of ACCESS
Oncology stock and was also a director.

On February 5, 2004, we completed the acquisition of ACCESS Oncology. For a
description of the interests of certain of our directors and executive officers,
please see the discussion in Proposal Two under the heading "Interests of
Certain Person in Matters to be Acted Upon" on page 24 of this proxy statement.

STOCK OWNERSHIP OF OUR DIRECTORS, EXECUTIVE OFFICERS,
AND 5% BENEFICIAL OWNERS

The following table shows information, as of March 1, 2004, concerning the
beneficial ownership of our common stock by:

- each person we know to be the beneficial owner of more than 5% of our
common stock;

- each of our directors (all of whom are nominees for re-election);

- each of our named executive officers shown in our Summary Compensation
Table; and

- all current directors and executive officers as a group.

As of December 31, 2003, there were 24,960,773 shares of our common stock
outstanding. In order to calculate a stockholder's percentage of beneficial
ownership, we include in the calculation those shares underlying options or
warrants beneficially owned by that stockholder that are vested or that will
vest within 60 days of December 31, 2003. Options or warrants held by other
stockholders that are not attributed to the named beneficial owner are
disregarded in this calculation. Beneficial ownership is determined in
accordance with the rules of the SEC and includes voting or investment power
with respect to the shares of our common stock. Unless we have indicated
otherwise, each person named in the table below has sole voting power and
investment power for the shares listed opposite such person's name, except to
the extent authority is shared by spouses under community property laws.

AMOUNT AND NATURE PERCENTAGE
OF BENEFICIAL OF SHARES
NAME AND ADDRESS OF BENEFICIAL OWNER(1) OWNERSHIP OUTSTANDING
--------------------------------------- ----------------- -----------

Wachovia Corporation(2).................................. 1,374,187 5.51%
Lindsay A. Rosenwald, M.D.(3)............................ 5,512,136 22.32%
Peter Morgan Kash(4)..................................... 1,044,680 4.16%
Michael S. Weiss(5)...................................... 642,385 2.57%
Bob Trachtenberg(6)...................................... 358,120 1.41%
Ira Weinstein(7)......................................... 245,620 *
Ron Bentsur(8)........................................... 97,494 *
Malcolm Hoenlein(9)...................................... 39,500 *
Lawrence Jay Kessel, M.D.(10) ........................... 21,000 *
Peter Salomon, M.D.(11) ................................. 15,500 *
I. Craig Henderson, M.D. ................................ 0 *
All current directors and executive officers as a
group(12).............................................. 7,459,369 28.91%

---------------

* Less than 1% of outstanding common stock

(1) The address of Wachovia Corporation is One Wachovia Center, Charlotte,
North Carolina 28288. The address of each of the directors and officers
listed is c/o Keryx Biopharmaceuticals, Inc., 750 Lexington Avenue, New
York, New York 10022.

(2) Based upon Schedule 13G filed February 11, 2004 with the SEC.

(3) Includes 250,485 shares of our common stock held by Paramount Capital
Investments LLC, an affiliate of Paramount Capital, Inc., of which Dr.
Rosenwald is Chairman. Also includes 194,600 shares of our common stock
held by funds managed by Paramount Capital Asset Management, Inc., of which
Dr. Rosenwald is the Chairman and sole stockholder. In addition, also
includes 12,500 shares of our common stock issuable upon the exercise of
options issued to Dr. Rosenwald, 14,064 shares of our common stock issuable
upon the exercise of a warrant held by Dr. Rosenwald and 50,110 shares of
our common stock issuable upon the exercise of a warrant held by Paramount
Capital Investments LLC. Also includes the 192,385 shares of our common
stock underlying an irrevocable stock purchase option that Dr. Rosenwald
has granted to Michael S. Weiss, our Chairman and Chief Executive Officer
(see

Footnote 5 below), and 75,000 shares of common stock underlying an
irrevocable stock purchase option that Dr. Rosenwald has granted to a third
party. Also includes 2,374,187 shares of our common stock registered in the
name of Jay Lobell, as trustee for the trust to which the shares were
transferred. Dr. Rosenwald disclaims beneficial ownership of all such
shares held by the trust.

(4) Includes 125,000 shares of our common stock issuable upon the exercise of
options and 38,930 shares of our common stock issuable upon the exercise of
a warrant. Also includes 120,000 shares of our common stock that Mr. Kash
transferred to an irrevocable family trust on January 29, 2004. Also
includes 1,500 shares of our common stock that are subject to a ten-year
purchase option granted to a charitable foundation.

(5) Includes 192,385 shares of our common stock currently held by Dr.
Rosenwald, a director and beneficial holder of more than 5% of our common
stock, all of which Mr. Weiss has the irrevocable right to purchase from
Dr. Rosenwald upon the exercise of an option granted to Mr. Weiss by Dr.
Rosenwald, which is exercisable within 60 days of December 31, 2003. Also
includes 450,000 shares of our common stock issuable upon the exercise of
options.

(6) Mr. Trachtenberg is our former General Counsel. Mr. Trachtenberg's
employment with us was terminated as of September 30, 2003. Amount
disclosed reflects shares of our common stock issuable upon exercise of
options.

(7) Mr. Weinstein is our former Interim Chief Financial Officer. Mr.
Weinstein's employment with us was terminated as of June 30, 2003. Amount
disclosed reflects shares of our common stock issuable upon exercise of
options.

(8) Includes 81,336 shares of our common stock issuable upon the exercise of
options.

(9) Includes 37,500 shares of our common stock issuable upon the exercise of
options.

(10) Includes 15,000 shares of our common stock issuable upon the exercise of
options.

(11) Includes 15,000 shares of our common stock issuable upon the exercise of
options.

(12) Includes 737,503 shares of our common stock issuable upon the exercise of
options and 103,104 shares of our common stock issuable upon the exercise
of warrants, provided that the 192,385 shares of our common stock
underlying the irrevocable stock purchase option granted by Dr. Rosenwald
to Mr. Weiss (see footnotes 3 and 5 above) have only been counted once for
purposes of calculating the shares beneficially owned by all current
directors and executive officers as a group. Includes only the current
executive officers and directors of Keryx, therefore, Mr. Trachtenberg and
Mr. Weinstein are excluded.

PROPOSAL ONE

ELECTION OF DIRECTORS; NOMINEES

Our amended and restated bylaws provide that the Board of Directors shall
consist of one or more members, as determined from time to time by resolution of
the Board of Directors. Currently, our Board of Directors consists of seven
members. These seven directors are to be re-elected at the Annual Meeting to
hold office until the next annual meeting and until a respective successor is
elected and has been qualified, or until such director resigns or is removed
from office. Management expects that each of the nominees will be available for
re-election, but if any of them is unable to serve at the time the election
occurs, the proxy will be voted for the election of another nominee to be
designated by a majority of the independent directors serving on our Board of
Directors.

CERTAIN INFORMATION CONCERNING THE DIRECTOR NOMINEES

The following biographies set forth the names of the director nominees,
their ages, the month and year in which they first became directors, their
positions with us, their principal occupations and employers for at least the
past five years, any other directorships held by them in companies that are
subject to the reporting requirements of the Exchange Act or any company
registered as an investment company under the Investment Company Act of 1940, as
well as additional information. There is no family relationship between any of
our

executive officers or directors and there are no arrangements or understandings
between any of our executive officers or directors and any other person pursuant
to which any of them are elected an officer or director other than an
understanding between us and Dr. I. Craig Henderson regarding his appointment to
our Board of Directors.

MICHAEL S. WEISS, 38, has served as our Chairman and Chief Executive
Officer since December 2002. From March 1999 to December 2002, Mr. Weiss served
as Chief Executive Officer and Chairman and later as the Executive Chairman of
ACCESS Oncology, a private biotechnology company that we acquired in February
2004 and that is dedicated to the in-licensing and development of clinical stage
oncology drugs. Previously, from November 1993 to March 1999, Mr. Weiss served
as Senior Managing Director of Paramount Capital, Inc., an NASD registered
broker-dealer. He currently serves as Vice Chairman of Genta, Inc., a
biopharmaceutical company. Mr. Weiss received a J.D. from Columbia Law School
and a B.A. from the State University of New York at Albany.

I. CRAIG HENDERSON, M.D., 62, has served on our Board of Directors since
March 2004. Dr. Henderson has served as President of Keryx Biopharmaceuticals
since March 11, 2004, and serves as the CEO and President of ACCESS Oncology,
the private biotechnology company that we acquired in February 2004, a position
he has held since January 2001. Dr. Henderson has served as Senior Consultant
and Director of Alza Pharmaceuticals since 1999. He also served as CEO and
Chairman of SEQUUS Pharmaceuticals from 1995 to 1999. Dr. Henderson received his
A.B. from Grinnell College and his M.D. from Columbia University's College of
Physicians and Surgeons.

PETER MORGAN KASH, 42, our Vice Chairman, has served on our Board of
Directors since October 1998. Since 1990, Mr. Kash has been a Senior Managing
Director of Paramount Capital, Inc. and a Director of Paramount Capital Asset
Management, Inc., which manages the investments of several funds specializing in
the technology and biotechnology sectors. From 1989 to 1991, Mr. Kash served as
an Associate Professor at Polytechnic University. Additionally, since 1996, he
has served as a Lecturer in Entrepreneurship and International Venture Capital
at the Wharton School of the University of Pennsylvania and was a visiting
professor in entrepreneurship at Nihon University in Tokyo, Japan from 1999 to
2001. He holds a B.S. in Management Science from the State University of New
York at Binghamton and an M.B.A. in Finance and Banking from Pace University.

MALCOLM HOENLEIN, 60, has served on our Board of Directors since January
2001. Mr. Hoenlein currently serves as the Executive Vice Chairman of the
Conference of Presidents of Major American Jewish Organizations, a position he
has held since 1986. He also serves as a director of Bank Leumi. Mr. Hoenlein
received his B.A. from Temple University and his M.A. from the University of
Pennsylvania.

LINDSAY A. ROSENWALD, M.D., 49, has served on our Board of Directors since
March 2000. He is an investment banker, as well as a venture capitalist and fund
manager. Dr. Rosenwald has served as Chairman of Paramount Capital, Inc. since
1992, Chairman of Paramount Capital Investments LLC, a merchant and investment
bank, since 1995, and Chairman of Paramount Capital Asset Management, Inc. since
1994. He also serves as a director of Indevus Pharmaceuticals, Inc. Dr.
Rosenwald received his B.S. in Finance from Pennsylvania State University and
his M.D. from the Temple University School of Medicine

LAWRENCE JAY KESSEL, M.D., 50, has served on our Board of Directors since
2003. Since 1984, Dr. Kessel has served as President of Lawrence J. Kessel, M.D.
& Associates, PC, a physician practice specializing in internal medicine and
geriatrics. He is an active attending staff and clinical instructor at Chestnut
Hill Hospital (University of Pennsylvania affiliate) and Roxborough Memorial
Hospital in Philadelphia, Pennsylvania. Dr. Kessel presently serves as a
director of Cypress Biosciences, Inc., NovaDel Pharma Inc., and Dor BioPharma,
Inc. He received his B.S. from the University of Pittsburgh and his M.D. from
the Temple University School of Medicine. Dr. Kessel is a board reviewer for the
American Board of Internal Medicine, as well as a Fellow of the American College
of Physicians. Dr. Kessel also serves on the advisory board of Independence Blue
Cross.

PETER SALOMON, M.D., 44, has served on our Board of Directors since 2003.
Dr. Salomon is a board certified gastroenterologist and, since July 1991, has
been in private practice with Gastroenterology Associates

of South Florida. Dr. Salomon presently serves as a director of Dor BioPharma,
Inc. Dr. Salomon received his B.S. from New York University and his M.D. from
New York University's School of Medicine.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE ELECTION OF
ALL OF THE NOMINEES FOR DIRECTORS. IF A CHOICE IS SPECIFIED ON THE PROXY BY THE
STOCKHOLDER, THE SHARES WILL BE VOTED AS SPECIFIED. IF NO SPECIFICATION IS MADE,
THE SHARES WILL BE VOTED "FOR" THE NOMINEES. THE AFFIRMATIVE VOTE OF THE HOLDERS
OF A PLURALITY OF THE SHARES OF COMMON STOCK REPRESENTED AND ENTITLED TO VOTE AT
THE ANNUAL MEETING AT WHICH A QUORUM IS PRESENT IS REQUIRED FOR THE ELECTION OF
THE NOMINEES.

PROPOSAL TWO

ISSUANCE OF COMMON STOCK TO FORMER STOCKHOLDERS OF
ACCESS ONCOLOGY UPON ACHIEVEMENT OF CERTAIN MILESTONES

On February 5, 2004, we completed the acquisition of ACCESS Oncology.
Following the acquisition and in accordance with the terms of the merger
agreement approved by our Board of Directors, ACCESS Oncology became our
wholly-owned subsidiary and the outstanding securities of ACCESS Oncology were
converted into the right to receive the merger consideration set forth in the
merger agreement. This merger consideration consists of 627,578 shares of our
common stock that have already been issued to the former preferred stockholders
of ACCESS Oncology and up to approximately 3,372,422 additional shares of our
common stock that are issuable to the former ACCESS Oncology stockholders upon
the achievement of certain development and revenue milestones for drug
candidates of ACCESS Oncology or if we engage in certain strategic transactions.
We are asking our stockholders to approve the issuance of these additional
shares of our common stock, as we will otherwise be required to deliver cash
having an equal value to the former preferred stockholders of ACCESS Oncology
upon the occurrence of those events.

BACKGROUND OF THE MERGER

Michael S. Weiss, our Chairman and Chief Executive Officer, was a
co-founder of ACCESS Oncology and held the position of chairman of its board of
directors prior to the merger. In the late fall of 2003, Mr. Weiss and Dr. I.
Craig Henderson, the president and chief executive officer and a director of
ACCESS Oncology, commenced discussions of our possible acquisition of ACCESS
Oncology. In light of those and certain other relationships set forth in more
detail below, our Board of Directors established a special committee of
independent directors to consider the terms of any potential transaction.

During December 2003, we and ACCESS Oncology negotiated a non-binding
letter of intent outlining potential terms of the transaction. The form of the
letter of intent was reviewed and approved by the special committee of our Board
of Directors at a meeting held on December 9, 2003 and executed by us and ACCESS
Oncology shortly thereafter. During the following weeks, we negotiated the terms
of the definitive merger agreement. On January 7, 2004, the special committee of
our Board of Directors held a meeting to consider adoption of the merger
agreement and approval of the transactions contemplated by the merger agreement.
This meeting included a presentation by a financial advisor retained by the
special committee to consider whether the terms of the transaction were fair,
from a financial point of view, to our stockholders who were not also
stockholders of ACCESS Oncology. Following the meeting, the special committee
unanimously recommended the approval of the merger agreement to our Board of
Directors. Acting on this recommendation, our Board of Directors approved the
merger agreement substantially on the terms as presented, as well as the
performance of the transactions contemplated by the merger agreement.

Delaware law and the terms of the merger agreement required that the
holders of ACCESS Oncology stock, which included two classes of preferred stock
and common stock, adopt the merger agreement and approve the merger prior to
consummation of the acquisition. Following the announcement of the execution of
the merger agreement, we and ACCESS Oncology discussed potential amendments to
the merger agreement designed to increase the likelihood of adoption of the
merger agreement and approval of the merger by the

ACCESS Oncology stockholders. Generally, the effects of these changes were to
accelerate payment of a portion of the merger consideration so that the ACCESS
Oncology preferred stockholders could receive up to approximately 630,000 shares
of our common stock immediately following the consummation of the merger,
regardless of whether development or revenue milestones relating to the ACCESS
Oncology drug candidates were achieved, and to expand the types of strategic
transactions that would result in an acceleration of the payment of the
remaining merger consideration. On February 5, 2004, our special committee
reviewed the proposed amendment to the merger agreement and obtained a revised
opinion from our financial advisor that the transactions contemplated by the
merger agreement, as proposed to be amended, were fair, from a financial point
of view, to our stockholders who were not also stockholders of ACCESS Oncology.
Our special committee unanimously recommended approval of the amendment to the
merger agreement to our full Board of Directors, who in turn approved the
amendment.

Also on February 5, 2004, following execution of the amendment to the
merger agreement, ACCESS Oncology obtained the consent of a majority of its
stockholders, and the merger became effective immediately before midnight of the
same day.

THE MERGER CONSIDERATION

The merger agreement, as amended, provides for the distribution to the
former ACCESS Oncology stockholders of a maximum of 4,000,000 shares of our
common stock. Of this amount, approximately 627,578 shares were distributed to
holders of ACCESS Oncology preferred stock. No stockholder approval was required
with respect to the issuance of this initial block of shares of our common stock
to the preferred stockholders of ACCESS Oncology.

The milestone consideration consists of up to an additional 3,372,422
shares of our common stock (or cash in lieu thereof if Proposal Two is not
approved) that will be distributed if and when certain milestones relating to
the development of drug candidates of ACCESS Oncology existing prior to the
merger are achieved. In addition, under the terms of the merger agreement, (i)
all of the milestone consideration will become immediately distributable if we
are sold or liquidated and one or more of the ACCESS Oncology drug candidates
are included in the sale or liquidation, (ii) a portion of the milestone
consideration will become immediately distributable upon the consummation of
certain non-ordinary course financing and strategic partnering transactions or
sales of all rights to any of the ACCESS Oncology products and (iii) a portion
of the milestone consideration will become immediately distributable, and no
further milestone consideration will thereafter be distributable, if all of the
ACCESS Oncology products are disposed of in a single transaction (other than a
spin off or a sale or liquidation of us as described above). We refer to the
transactions that will accelerate payment of the milestone consideration as
"accelerating events."

Assuming no accelerating event occurs, the following number of shares of
Keryx common stock (or cash in lieu thereof if Proposal Two is not approved)
will become distributable upon the occurrence of the following events. In each
case, the ACCESS Oncology products that will trigger the milestones refer to
existing drug candidates of ACCESS Oncology as of the effective date of the
merger agreement:

MILESTONE NUMBER OF SHARES
--------- ----------------

Enrollment of first patient in a Keryx-sponsored Phase III
(or other Pivotal) clinical trial of any ACCESS Oncology
product................................................... 500,000
First acceptance by the Food and Drug Administration of the
filing of a New Drug Application for any ACCESS Oncology
product................................................... 750,000
First approval by the Food and Drug Administration of any
ACCESS Oncology product................................... 1,750,000
First time that gross sales of all ACCESS Oncology products
are equal to or greater than $100,000,000 in a
twelve-month period....................................... 372,422
----------
TOTAL:.................................................... 3,372,422

The issuance of shares of our common stock as milestone consideration
requires the approval of our stockholders, which is the subject of this Proposal
Two. If the issuance of the shares of our common stock

payable as milestone consideration is not approved by our stockholders, we will
instead be obligated to deliver cash to the former ACCESS Oncology stockholders
in an amount equal to the value of the shares of our common stock that would
have otherwise been delivered upon the achievement of any milestone or the
occurrence of any accelerating event.

Generally, the merger agreement provides that the value of our common stock
shall be determined based on the market price at or around the time of the
achievement of each milestone or the occurrence of an accelerating event.
Assuming, however, a value per share of our common stock of $15.42, which was
the closing price reported on Nasdaq on March 30, 2004, the total amount of cash
that we would be required to deliver if all four milestones are achieved would
be approximately $51.4 million. We do not currently have, and there can be no
assurance that at the time the milestones are achieved or an accelerating event
occurs that we will have, cash sufficient to satisfy the payment of the
milestone consideration. In order to ensure that we have sufficient cash to
continue our operations and in order to satisfy our undertakings set forth in
the merger agreement, we are seeking your approval of the issuance of shares of
our common stock in satisfaction of the milestone consideration.

INTERESTS OF CERTAIN PERSONS IN MATTERS TO BE ACTED UPON

Certain of our directors and executive officers had interests in the merger
with ACCESS Oncology that are different from, or in addition to, the interests
of our other stockholders. To the extent that these additional interests relate
to stock that these individuals held in ACCESS Oncology prior to the merger,
they may also have a competing interest in the adoption of Proposal Two, as it
will determine whether they receive our common stock or cash in lieu thereof
upon the achievement of any of the milestones or the occurrence of the
accelerating events. The interests that these individuals had in the merger
included the following:

- Mr. Weiss, our Chairman and Chief Executive Officer, was a founder and
former executive officer of ACCESS Oncology, was the single largest
stockholder of ACCESS Oncology, and was a member of the ACCESS Oncology
board of directors prior to the merger.

- Dr. Rosenwald, one of our directors, and certain entities affiliated with
Dr. Rosenwald held substantial amounts of ACCESS Oncology stock, and Dr.
Rosenwald was a director of ACCESS Oncology prior to the merger.

- Dr. Rosenwald, Mr. Weiss, and Dr. I. Craig Henderson, our President, and
Chief Executive Officer of our subsidiary, ACCESS Oncology, or persons or
entities affiliated with them, held certain promissory notes issued by
ACCESS Oncology having an aggregate principal amount of $775,000; ACCESS
Oncology would likely not have been in a position to satisfy its
obligations under these notes, which we repaid following the merger.

- Dr. Rosenwald and Mr. Weiss had directly or indirectly guaranteed certain
promissory notes issued by ACCESS Oncology, and the merger substantially
reduced the likelihood that Dr. Rosenwald and Mr. Weiss would incur
personal liability upon the default of those notes, which we have since
satisfied in full.

- ACCESS Oncology owed Mr. Weiss approximately $380,000 in deferred
compensation, the payment of which was made following the merger.

- ACCESS Oncology owed Dr. Henderson, who is now our President and remains
President and Chief Executive Officer of ACCESS Oncology, approximately
$61,800 in deferred compensation, the payment of which was made following
the merger.

- Dr. Kessel and Mr. Kash, two of our directors, and certain of Mr. Weiss
and Dr. Rosenwald's family members held stock in ACCESS Oncology, which
would likely have had little to no value in the absence of the merger.

- The merger agreement obligates us to indemnify former directors and
officers of ACCESS Oncology, including Mr. Weiss, Dr. Henderson and Dr.
Rosenwald, for claims arising as a result of their service of ACCESS
Oncology.

As a result of these potential conflicts of interest, our Board of
Directors formed a special committee of independent directors to consider and
approve the terms of the merger agreement, as amended. The members of the
special committee were advised of the existence of these potential conflicts of
interest. The special committee, after considering the terms of the merger
agreement and obtaining the opinion of a financial advisor, determined that the
approval and adoption of the merger agreement, as amended, was in the best
interests of our stockholders and recommended approval to our full Board of
Directors.

REGISTRATION AND LISTING WITH NASDAQ

The merger agreement provides that, by the 45th day after the distribution
of our common stock to the former holders of ACCESS Oncology preferred stock and
by the 45th day after each distribution of our common stock as milestone
consideration, we must prepare and file with the SEC a resale registration
statement covering the resale of the shares of our common stock included in such
distribution. We have agreed to use our best efforts to cause each registration
statement to be declared effective under the Securities Act as promptly as
possible after filing, and to use our best efforts to keep such registration
statement effective until the second anniversary of the date it is declared
effective (or any earlier date on which the distribution of such common stock
has been completed). We have agreed to bear all expenses in connection with
these registrations other than underwriting discounts and commissions, if any,
which will be payable by the selling stockholders.

The registration rights we have granted are subject to certain restrictions
and limitations. Among other things, as a condition precedent to the grant of
such registration rights, the selling stockholders must agree to suspend
disposition of our common stock upon notice from us of a blackout period,
generally a time when we are aware of material, non-public information that
would make sales under the registration statement inappropriate. Selling
stockholders may also be required to furnish certain information to us for
inclusion in any registration statement covering resales of our common stock by
them, and to indemnify us for certain liabilities relating to any such
registration statement.

We have already notified Nasdaq of the listing of the initial 627,578
shares of our common stock issued to the former ACCESS Oncology preferred
stockholders. If our stockholders approve the issuance of the additional
3,372,422 shares of our common stock issuable as milestone consideration, we
will notify Nasdaq of the additional issuance only in connection with any
distribution that actually occurs upon the achievement of any milestone or the
occurrence of an accelerating event.

FINANCIAL AND OTHER INFORMATION

Our annual, audited financial statements for the fiscal years ending
December 31, 2003, 2002, and 2001 contained in our annual report to
stockholders, which is provided together with this proxy statement, and the
information contained therein under the headings "Management's Discussion and
Analysis of Financial Condition and Results of Operations" and "Quantitative and
Qualitative Disclosure about Market Risk," are incorporated herein by reference.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE APPROVAL OF
THE ISSUANCE OF SHARES OF OUR COMMON STOCK AS THE MERGER CONSIDERATION SET FORTH
IN THE MERGER AGREEMENT WITH ACCESS ONCOLOGY. THE AFFIRMATIVE VOTE OF A MAJORITY
OF THE SHARES OF COMMON STOCK REPRESENTED AND ENTITLED TO VOTE AT THE ANNUAL
MEETING AT WHICH A QUORUM IS PRESENT IS REQUIRED FOR APPROVAL AND RATIFICATION.

PROPOSAL THREE

APPROVAL OF THE 2004 LONG-TERM INCENTIVE PLAN

On April 14, 2004, our Compensation Committee and our Board of Directors
adopted, subject to stockholder approval at the Annual Meeting, the Keryx
Biopharmaceuticals, Inc. 2004 Long-Term Incentive Plan (the "2004 Plan"). The
2004 Plan will become effective as of the date it is approved by our
stockholders.

As of April 14, 2004, there were approximately 22 employees, officers and
directors, three consultants based in Israel, and consultants based in the
United States eligible to participate in the 2004 Plan.

SUMMARY OF THE 2004 PLAN

Purpose. The purpose of the 2004 Plan is to promote our success by linking
the personal interests of our employees, officers, directors and consultants to
those of our stockholders, and by providing participants with an incentive for
outstanding performance. A copy of the 2004 Plan is included as Annex C.

Permissible Awards. The 2004 Plan authorizes the granting of awards in any
of the following forms:

- options to purchase shares of our common stock,

- stock appreciation rights,

- restricted stock and restricted stock units,

- performance awards payable in stock or cash,

- dividend equivalents, and

- other stock-based awards.

Shares Available for Awards. Subject to adjustment as provided in the 2004
Plan, the maximum number of shares of common stock reserved and available for
issuance pursuant to awards granted under the 2004 Plan is 4,000,000. Except for
shares retained to satisfy tax withholding obligations, only shares actually
issued under the 2004 Plan count against the total number of shares available
under the 2004 Plan.

Limitations on Awards. The maximum number of shares of our common stock
with respect to one or more options or stock appreciation rights that may be
granted during any one calendar year under the 2004 Plan to any one participant
is 4,000,000. The maximum fair market value of any awards (other than options or
stock appreciation rights) that may be received by a participant (less any
consideration paid by the participant for such award) during any one calendar
year under the 2004 Plan is $5,000,000.

Administration. The Compensation Committee of our Board of Directors will
administer the 2004 Plan. The Compensation Committee will have the authority to:

- designate participants;

- determine the type or types of awards to be granted to each participant
and the number, terms and conditions thereof;

- establish, adopt or revise any rules and regulations as it may deem
advisable to administer the 2004 Plan; and

- make all other decisions and determinations that may be required under
the 2004 Plan.

The Board of Directors may at any time administer the 2004 Plan. If it does
so, it will have all the powers of the Compensation Committee.

Stock Options. The Compensation Committee is authorized to grant incentive
stock options or nonstatutory stock options under the 2004 Plan. The terms of an
incentive stock option must meet the requirements of Section 422 of the Internal
Revenue Code. The exercise price of any option may not be less than the fair
market value of the underlying stock on the date of grant (unless our Board
specifically so authorizes a below-market grant for non-qualified stock
options), and no option may have a term of more than 10 years.

Stock Appreciation Rights. The Compensation Committee may also grant stock
appreciation rights ("SARs"). These provide the holder with the right to receive
the excess, if any, of the fair market value of one share of our common stock on
the date of exercise, over the base price of the stock appreciation right as
determined by the Compensation Committee, which will not be less than the fair
market value of one share of our common stock on the grant date.

Restricted Stock Awards. The Compensation Committee may make awards of
restricted stock or restricted stock units to participants, which will be
subject to such restrictions on transferability and other restrictions as the
Compensation Committee may impose (including, without limitation, limitations on
the right to vote restricted stock or the right to receive dividends, if any, on
the restricted stock).

Performance Awards. The Compensation Committee may grant performance
awards that are designated in cash (performance units) or in shares of our
common stock (performance shares). The Compensation Committee will have the
complete discretion to determine the number of performance awards granted to any
participant and to set performance goals and other terms or conditions to
payment of the performance awards in its discretion which, depending on the
extent to which they are met, will determine the number and value of performance
awards that will be paid to the participant.

Dividend Equivalents. The Compensation Committee is authorized to grant
dividend equivalents to participants subject to such terms and conditions, as
may be selected by the Compensation Committee. Dividend equivalents entitle the
participant to receive payments equal to dividends with respect to all or a
portion of the shares of our common stock subject to an award, as determined by
the Compensation Committee.

Other Stock-Based Awards. The Compensation Committee may, subject to
limitations under applicable law, grant to participants such other awards that
are payable in, valued in whole or in part by reference to, or otherwise based
on or related to shares of our common stock as deemed by the Compensation
Committee to be consistent with the purposes of the 2004 Plan, including,
without limitation, shares of our common stock awarded purely as a bonus and not
subject to any restrictions or conditions, convertible or exchangeable debt
securities, other rights convertible or exchangeable into shares of our common
stock, and awards valued by reference to book value of shares of our common
stock or the value of securities of or the performance of specified parents or
subsidiaries. The Compensation Committee will determine the terms and conditions
of any such stock-based awards.

Performance Goals. The $1 million annual deduction limit imposed by
Section 162(m) of the Internal Revenue Code applies to companies that have
common equity securities registered under the Exchange Act. Market-priced
options and SARs granted under the 2004 Plan will automatically qualify as
performance-based awards that are fully deductible by us without regard to the
$1 million deduction limit imposed by Section 162(m) of the Internal Revenue
Code. The Compensation Committee may designate any other award under the 2004
Plan (such as, for example, a cash incentive bonus or restricted stock award) as
a qualified performance-based award in order to make the award fully deductible
under Section 162(m) of the Internal Revenue Code. If an award is so designated,
the Compensation Committee must establish objectively determinable performance
goals for the award based on one or more of the following performance criteria:

- Revenue

- Sales

- Profit (net profit, operating profit, economic profit, profit margins or
other corporate profit measures)

- Earnings (EBIT, EBITDA, earnings per share, or other corporate earnings
measures)

- Net income (before or after taxes, operating income or other income
measures)

- Cash (cash flow, cash generation, working capital or other cash measures)

- Stock price or performance

- Total stockholder return (stock price appreciation plus reinvested
dividends)

- Return on equity

- Return on assets

- Return on investment

- Market share

- Improvements in capital structure

- Expense (expense management, expense ratio, expense efficiency ratios or
other expense measures)

- Business expansion or consolidation (acquisitions, divestitures,
in-licensing and product acquisitions)

- Market capitalization

- Clinical and regulatory milestones

- Corporate financing activities

- Supply, production and manufacturing milestones

- Corporate partnerships and strategic alliances

The Compensation Committee must establish such goals prior to the beginning
of the period for which such performance goal relates (or such later date as may
be permitted under applicable tax regulations), and the Compensation Committee
may not increase any award or, except in the case of certain qualified
terminations of employment, waive the achievement of any specified goal. Any
payment of an award granted with performance goals will be conditioned on the
written certification of the Compensation Committee in each case that the
performance goals and any other material conditions were satisfied.

Limitations on Transfer; Beneficiaries. Except as otherwise determined by
the Compensation Committee, no award will be assignable or transferable by a
participant other than by will or the laws of descent and distribution, or
(except in the case of an incentive stock option) pursuant to a qualified
domestic relations order, or (except in the case of an incentive stock option or
a restricted stock award) to the participant's immediate family members, trusts
for their benefit, or legal entities wholly owned by such family members. A
participant may, in the manner determined by the Compensation Committee,
designate a beneficiary to exercise the rights of the participant and to receive
any distribution with respect to any award upon the participant's death.

Acceleration Upon Certain Events. Unless otherwise provided in an award
certificate, if a change in control (as defined in the 2004 Plan) occurs, all of
such participant's outstanding options and SARs will become fully vested and
exercisable, all restrictions on his or her outstanding restricted stock awards
will lapse and any performance-based criteria with respect to outstanding
awards, other than awards intended to be qualified performance-based awards
exempt from Section 162(m) of the Internal Revenue Code, will be deemed to be
satisfied at the greater of "target" or actual performance as of the date of the
change in control. In addition, the Compensation Committee may in its discretion
accelerate awards for any other reason. The Compensation Committee may
discriminate among participants or among awards in exercising such discretion.

Adjustments. In the event of a stock split, a dividend payable in shares
of our common stock, or a combination or consolidation of our common stock into
a lesser number of shares, the share authorization limits under the 2004 Plan
will automatically be adjusted proportionately, and the shares then subject to
each award will automatically be adjusted proportionately without any change in
the aggregate purchase price for such award. If we are involved in another
corporate transaction or event that affects our common stock, such as an
extraordinary cash dividend, recapitalization, reorganization, merger,
consolidation, split-up, spin-off, combination or exchange of shares, the share
authorization limits under the 2004 Plan will be adjusted proportionately, and
the Compensation Committee may adjust outstanding awards to preserve the
benefits or potential benefits of the awards.

TERMINATION AND AMENDMENT

Our Board of Directors or the Compensation Committee may, at any time and
from time to time, terminate or amend the 2004 Plan without stockholder
approval, but if an amendment to the 2004 Plan would, in the reasonable opinion
of the Board of Directors or the Compensation Committee, materially increase the
benefits accruing to participants, materially increase the number of shares of
our common stock issuable under the 2004 Plan, expand the types of awards under
the 2004 Plan, materially modify the requirements for eligibility, materially
extend the term of the 2004 Plan, or otherwise constitute a material amendment
requiring stockholder approval under applicable laws, policies or regulations,
then such amendment will be subject to stockholder approval. In addition, the
Board of Directors or the Compensation Committee may condition any amendment on
the approval of our stockholders for any other reason, including necessity or
advisability under tax, securities or other applicable laws, policies or
regulations. No termination or amendment of the 2004 Plan may adversely affect
any award previously granted under the 2004 Plan without the written consent of
the participant. The Compensation Committee may amend or terminate outstanding
awards. However, such amendments may require the consent of the participant and,
unless approved by our stockholders or otherwise permitted by the antidilution
provisions of the 2004 Plan, the exercise price of an outstanding option may not
be reduced, directly or indirectly, and the original term of an option may not
be extended.

CERTAIN FEDERAL TAX EFFECTS

Nonstatutory Stock Options. There will be no federal income tax
consequences to the optionee or to us upon the grant of a nonstatutory stock
option under the 2004 Plan. When the optionee exercises a non-nonstatutory
option, however, the optionee will recognize ordinary income in an amount equal
to the excess of the fair market value of our common stock received upon
exercise of the option at the time of exercise over the exercise price, and we
will be entitled to a corresponding federal income tax deduction. Any gain that
the optionee realizes when the optionee later sells or disposes of the option
shares will be short-term or long-term capital gain, depending on how long the
shares were held.

Incentive Stock Options. There typically will be no federal income tax
consequences to the optionee or to us upon the grant or exercise of an incentive
stock option. If the optionee holds the option shares for the required holding
period of at least two years after the date the option was granted or one year
after exercise, the difference between the exercise price and the amount
realized upon sale or disposition of the option shares will be long-term capital
gain or loss, and we will not be entitled to a federal income tax deduction. If
the optionee disposes of the option shares in a sale, exchange, or other
disqualifying disposition before the required holding period ends, the optionee
will recognize taxable ordinary income in an amount equal to the excess of the
fair market value of the option shares at the time of exercise over the exercise
price, and we will be allowed a federal income tax deduction equal to such
amount. While the exercise of an incentive stock option does not result in
current taxable income, the excess of the fair market value of the option shares
at the time of exercise over the exercise price will be an item of adjustment
for purposes of determining the optionee's alternative minimum taxable income.

Transfers of Options. The Compensation Committee may, but is not required
to, permit the transfer of nonstatutory stock options granted under the 2004
Plan. Based on current tax and securities regulations, such transfers, if
permitted, are likely to be limited to gifts to members of the optionee's
immediate family or certain entities controlled by the optionee or such family
members. The following paragraphs summarize the likely income, estate, and gift
tax consequences to the optionee, us, and any transferees, under present federal
tax regulations, upon the transfer and exercise of such options.

Federal Income Tax. There will be no federal income tax consequences to
the optionee, us, or the transferee upon the transfer of a nonstatutory stock
option. However, the optionee will recognize ordinary income when the transferee
exercises the option, in an amount equal to the excess of the fair market value
of the option shares upon the exercise of such option over the exercise price,
and we will be entitled to a corresponding federal income tax deduction. The
gain, if any, realized upon the transferee's subsequent sale or disposition of
the option shares will constitute short-term or long-term capital gain to the
transferee,

depending on the transferee's holding period. The transferee's basis in the
stock will be the fair market value of such stock at the time of exercise of the
option.

Federal Estate and Gift Tax. If an optionee transfers a nonstatutory
stock option to a transferee during the optionee's life but before the option
has become exercisable, the optionee will not be treated as having made a
completed gift for federal gift tax purposes until the option becomes
exercisable. However, if the optionee transfers a fully exercisable option
during the optionee's life, the optionee will be treated as having made a
completed gift for federal gift tax purposes at the time of the transfer. If the
optionee transfers an option to a transferee by reason of death, the option will
be included in the decedent's gross estate for federal estate tax purposes. The
value of such option for federal estate or gift tax purposes may be determined
using a "Black-Scholes" or other appropriate option pricing methodology, in
accordance with requirements of the Internal Revenue Service.

Stock Appreciation Rights. A participant receiving a SAR will not
recognize income, and we will not be entitled to a tax deduction, at the time
the award is granted. When the participant exercises the SAR, the amount of cash
and the fair market value of any shares of our common stock received will be
ordinary income to the participant and we will be entitled to a corresponding
federal income tax deduction at that time, subject to any applicable limitations
under Section 162(m) of the Internal Revenue Code.

Restricted Stock. Unless a participant makes an election to accelerate
recognition of the income to the date of grant as described below, the
participant will not recognize income, and we will not be entitled to a federal
income tax deduction, at the time a restricted stock award is granted. When the
restrictions lapse, the participant will recognize ordinary income equal to the
fair market value of our common stock as of that date (less any amount the
participant paid for the stock), and we will be entitled to a corresponding
federal income tax deduction at that time, subject to any applicable limitations
under Section 162(m) of the Internal Revenue Code. If the participant files an
election under Section 83(b) of the Internal Revenue Code within 30 days after
the date of grant of the restricted stock, the participant will recognize
ordinary income as of the date of grant equal to the fair market value of the
restricted stock as of that date (less any amount paid for the stock), and we
will be entitled to a corresponding federal income tax deduction at that time,
subject to any applicable limitations under Section 162(m) of the Internal
Revenue Code. Any future appreciation in the stock will be taxable to the
participant at capital gains rates. However, if the stock is later forfeited,
the participant will not be able to recover the tax previously paid pursuant to
the election under Section 83(b) of the Internal Revenue Code.

Restricted Stock Units A participant will not recognize income, and we
will not be allowed a tax deduction, at the time a restricted stock unit award
is granted. Upon issuance of shares of common stock in settlement of a
restricted stock unit award, a participant will recognized ordinary income equal
to the fair market value of the common stock as of that date (less any amount he
or she paid for the stock), and we will be allowed a corresponding federal
income tax deduction at that time, subject to any applicable limitations under
Section 162(m) of the Internal Revenue Code.

Performance Awards. A participant generally will not recognize income, and
we will not be entitled to a federal income tax deduction, at the time
performance awards are granted, so long as the awards are subject to a
substantial risk of forfeiture. When the participant receives or has the right
to receive payment of cash or performance shares under the performance award,
the cash amount of the fair market value of the shares of our common stock will
be ordinary income to the participant, and we will be entitled to a
corresponding federal income tax deduction at that time, subject to any
applicable limitations under Section 162(m) of the Internal Revenue Code.

The table below reflects awards granted under the 2004 Plan prior to the
date of this proxy statement. Any future awards under the 2004 Plan will be made
at the discretion of our Board of Directors or the Compensation Committee, as
the case may be. Consequently, we cannot determine either the benefits or
amounts that will be received in the future by any person or group pursuant to
the 2004 Plan.

2004 LONG-TERM INCENTIVE PLAN

NAME AND POSITION DOLLAR VALUE(1) NUMBER OF OPTIONS
---------------------------------- --------- -------------

Michael S. Weiss.................. (1) 0
Chairman and Chief Executive
Officer.........................
Ron Bentsur....................... (1) 0
VP of Finance and Investor
Relations.......................
Bob Trachtenburg.................. (1) 0
Former General Counsel
Ira Weinstein..................... (1) 0
Former Interim Chief Financial
Officer
All Executive Officers as a 0
Group........................... (1)
All Non-Executive Directors as a 150,000(2)
Group........................... (1)
All Non-Executive Officer 0
Employees as a Group............ (1)

---------------

(1) The dollar value of the above options is dependent on the difference
between the exercise price and the fair market value of the
underlying shares on the date of exercise. The closing price per
share of the common stock on April 27, 2004 was $19.07.

(2) Options granted in June 2003.

THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE "FOR" THE APPROVAL OF THE KERYX 2004 LONG-TERM INCENTIVE PLAN. THE
AFFIRMATIVE VOTE OF A MAJORITY OF THE SHARES OF COMMON STOCK REPRESENTED AND
ENTITLED TO VOTE AT THE ANNUAL MEETING AT WHICH A QUORUM IS PRESENT IS REQUIRED
FOR APPROVAL AND RATIFICATION.

PROPOSAL FOUR

APPROVAL OF THE DELISTING OF OUR COMMON STOCK FROM THE
ALTERNATIVE INVESTMENT MARKET OF THE LONDON STOCK EXCHANGE

On April 14, 2004, our Board approved, subject to stockholder approval and
ratification at the Annual Meeting, the delisting of our common stock from the
Alternative Investment Market of the London Stock Exchange. The current trading
market for our common stock on the Alternative Investment Market does not
provide liquidity for our stockholders. Ongoing legal fees, stock exchange fees,
the costs of investor relations, press releases and potential additional costs
and related management time and attention associated with related rulemaking
from the Alternative Investment Market also represent, collectively, a
substantial annual burden to us. Moreover, our Board of Directors does not
believe that the delisting of our common stock from the Alternative Investment
Market will have a material adverse effect on our stockholders.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE DELISTING OF
OUR COMMON STOCK FROM THE ALTERNATIVE INVESTMENT MARKET. THE AFFIRMATIVE VOTE OF
THE HOLDERS OF 75% OF THE SHARES OF COMMON STOCK REPRESENTED AND ENTITLED TO
VOTE AT THE ANNUAL MEETING AT WHICH A QUORUM IS PRESENT IS REQUIRED FOR APPROVAL
AND RATIFICATION.

PROPOSAL FIVE

APPROVAL OF THE AMENDMENT OF OUR CERTIFICATE OF INCORPORATION
TO INCREASE THE NUMBER OF SHARES OF OUR AUTHORIZED COMMON STOCK

GENERAL

Our amended and restated certificate of incorporation currently contains an
authorization of 40,000,000 shares of common stock. The Board of Directors
recommends stockholder approval of an amendment to our amended and restated
certificate of incorporation increasing the number of shares of our authorized
common stock to 60,000,000 shares.

Article IV of our amended and restated certificate of incorporation, as
amended to date, establishes the aggregate number of shares that we are
authorized to issue as 45,000,000, of which 40,000,000 are designated as common
stock and 5,000,000 are designated as preferred stock. If Proposal Five is
approved by our stockholders, Article IV would be amended to increase the
aggregate number of shares which we are authorized to issue by 20,000,000 shares
(from 45,000,000 to 65,000,000), all of which increase would be designated as
common stock, resulting in a total of 60,000,000 authorized shares of common
stock. The number of authorized shares of preferred stock would remain
unchanged.

PURPOSES AND EFFECTS OF THE AMENDMENT

The additional common stock for which authorization is sought would be a
part of the existing class of common stock and, if and when issued, would have
the same rights and privileges as the common stock presently issued and
outstanding.

Except for shares reserved or to be reserved for the issuance of shares of
common stock underlying certain options to purchase shares of our common stock,
and those shares which may be issued pursuant to our merger agreement with
ACCESS Oncology (if Proposal Two is approved), we have no agreements or
understandings concerning the issuance of any additional common stock. However,
our Board of Directors believes that the increased authorization of common stock
is advisable at this time so that shares will be available for issuance in the
future on a timely basis if such need arises in connection with financings,
acquisitions or other corporate purposes. This will enable us to take advantage
of market conditions, the availability of favorable financing, and opportunities
for acquisitions, without the delay and expense associated with convening a
special stockholders' meeting.

Unless required under Delaware law or our amended and restated certificate
of incorporation or the NASD Rules, our Board of Directors will be able to
provide for the issuance of the additional shares of common stock without
further action by our stockholders and no further authorization by the
stockholders will be sought prior to such issuance.

Although not designed or intended for such purposes, the effect of the
proposed increase in the authorized common stock might be to render more
difficult or to discourage a merger, tender offer, proxy contest or change in
control of us and the removal of management, which stockholders might otherwise
deem favorable. The authority of our Board of Directors to issue common stock
might be used to create voting impediments or to frustrate an attempt by another
person or entity to effect a takeover or otherwise gain control of us because
the issuance of additional common stock would dilute the voting power of the
common stock and preferred stock then outstanding. Our common stock could also
be issued to purchasers who would support our Board of Directors in opposing a
takeover bid which our Board determines not to be in our best interests and
those of our stockholders.

Our amended and restated certificate of incorporation and bylaws currently
contain provisions approved by our stockholders that could have the effect of
making it more difficult for a third party to acquire, or of discouraging a
third party from attempting to acquire, or control us. These provisions could
limit the price that certain investors might be willing to pay in the future for
shares of our common stock. Our amended and restated certificate of
incorporation allows us to issue preferred stock with rights senior to those of
the common stock without any further vote or action by the stockholders and our
amended and restated bylaws eliminate

the right of stockholders to call a special meeting of stockholders, which could
make it more difficult for stockholders to effect certain corporate actions.
These provisions could also have the effect of delaying or preventing a change
in control. The issuance of preferred stock could decrease the amount of
earnings and assets available for distribution to the holders of our common
stock or could adversely affect the rights and powers, including voting rights,
of such holders. In certain circumstances, such issuance could have the effect
of decreasing the market price of our common stock.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE APPROVAL OF
THE AMENDMENT OF OUR CERTIFICATE OF INCORPORATION TO INCREASE THE NUMBER OF
SHARES OF OUR AUTHORIZED SHARES OF OUR COMMON STOCK. THE AFFIRMATIVE VOTE OF A
MAJORITY OF THE SHARES OF COMMON STOCK REPRESENTED AND ENTITLED TO VOTE AT THE
ANNUAL MEETING AT WHICH A QUORUM IS PRESENT IS REQUIRED FOR APPROVAL AND
RATIFICATION.

ADDITIONAL INFORMATION

HOUSEHOLDING OF ANNUAL MEETING MATERIALS

Some banks, brokers and other nominee record holders may be participating
in the practice of "householding" proxy statements and annual reports. This
means that only one copy of our proxy statement or annual report may have been
sent to multiple stockholders in your household. We will promptly deliver a
separate copy of either document to you if you contact us at: Keryx
Biopharmaceuticals, Inc., 750 Lexington Avenue, New York, New York 10022, attn:
Ron Bentsur. You may also contact Ron Bentsur, our Vice President of Finance and
Investor Relations, at (212) 531-5971.

If you want to receive separate copies of the proxy statement and annual
report in the future, or if you are receiving multiple copies and would like to
receive only one copy for your household, you should contact your bank, broker,
or other nominee record holder, or you may contact us at the above address or
phone number.

STOCKHOLDER PROPOSALS FOR OUR 2005 ANNUAL MEETING

Only proper proposals under Rule 14a-8 of the Exchange Act which are timely
received will be included in the proxy materials for our next annual meeting. In
order to be considered timely, such proposal must be received by our Secretary,
Ron Bentsur, at 750 Lexington Avenue, New York, New York 10022 no later than
December 30, 2004. We suggest that stockholders submit any stockholder proposal
by certified mail, return receipt requested.

Our bylaws require stockholders to provide advance notice to the Company of
any stockholder director nomination(s) and any other matter a stockholder wishes
to present for action at an annual meeting of stockholders (other than matters
to be included in our proxy statement, which are discussed in the previous
paragraph). The notice must be provided within a prescribed time frame, which is
generally calculated by reference to the date of the most recent annual meeting.
Assuming that our Annual Meeting is held on or after June 10, 2004, as we
currently anticipate, notice would be required no earlier than March 14, 2005,
and no later than April 11, 2005. If a stockholder fails to provide timely
notice of a proposal to be presented at our 2005 Annual Meeting of Stockholders,
the proxy designated by our Board of Directors will have discretionary authority
to vote on any such proposal that may come before the meeting.

OTHER MATTERS

Our Board of Directors does not know of any other matters that may come
before the meeting. However, if any other matters are properly presented to the
meeting, it is the intention of the person named in the accompanying proxy card
to vote, or otherwise act, in accordance with their judgment on such matters.

SOLICITATION OF PROXIES

We will bear the cost of solicitation of proxies. In addition to the
solicitation of proxies by mail, our officers and employees may solicit proxies
in person or by telephone. We may reimburse brokers or persons holding stock in
their names, or in the names of their nominees, for their expenses in sending
proxies and proxy material to beneficial owners.

INCORPORATION OF INFORMATION BY REFERENCE

The stock performance graph, the Compensation Committee Report, and the
Audit Committee Report, each contained in this proxy statement, are not deemed
filed with the SEC and shall not be deemed incorporated by reference into any
prior or future filings made by us under the Securities Act or the Exchange Act,
except to the extent that we specifically incorporate such information by
reference.

Our annual audited financial statements for the fiscal years ending
December 31, 2003, 2002, and 2001 contained in our annual report to
stockholders, which is provided together with this proxy statement, and the
information contained therein under the headings "Management's Discussion and
Analysis of Financial Condition and Results of Operations" and "Quantitative and
Qualitative Disclosure about Market Risk," are incorporated herein by reference.

By Order of the Board of Directors

/s/ Ron Bentsur
Ron Bentsur
Secretary

New York, New York
April 29, 2004

OUR BOARD OF DIRECTORS HOPES THAT STOCKHOLDERS WILL ATTEND THE 2004 ANNUAL
MEETING OF STOCKHOLDERS. WHETHER OR NOT YOU PLAN TO ATTEND, YOU ARE URGED TO
COMPLETE, DATE, SIGN AND RETURN THE ENCLOSED PROXY CARD IN THE ACCOMPANYING
ENVELOPE. A PROMPT RESPONSE WILL GREATLY FACILITATE ARRANGEMENTS FOR THE ANNUAL
MEETING AND YOUR COOPERATION WILL BE APPRECIATED. STOCKHOLDERS WHO ATTEND THE
ANNUAL MEETING MAY VOTE THEIR STOCK PERSONALLY, EVEN THOUGH THEY HAVE SENT IN
THEIR PROXY CARD.

ANNEX A

PROXY CARD

KERYX BIOPHARMACEUTICALS, INC.
PROXY FOR ANNUAL MEETING OF STOCKHOLDERS -- JUNE 10, 2004
(THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS OF THE COMPANY)

(Continue and sign on the Reverse Side)

A-1

ANNUAL MEETING OF STOCKHOLDERS
KERYX BIOPHARMACEUTICALS, INC.
JUNE 10, 2004

Please Detach and Mail in the Envelope Provided

Please mark your votes as in this example: [X]

PROPOSAL ONE: ELECTION OF DIRECTORS

FOR the election of all WITHHOLD AUTHORITY to
nominees below (except as vote for all nominees
marked to below
the contrary below) [ ]
[ ]

INSTRUCTIONS: TO WITHHOLD AUTHORITY TO VOTE FOR AN INDIVIDUAL NOMINEE, STRIKE A
LINE THROUGH THAT NOMINEE'S NAME IN THE LIST BELOW.

NOMINEES: Michael S. Weiss
I. Craig Henderson, M.D.
Malcolm Hoenlein
Peter M. Kash
Lawrence Jay Kessel, M.D.
Lindsay A. Rosenwald, M.D.
Peter Salomon, M.D.

PROPOSAL TWO: ISSUANCE OF COMMON STOCK TO FORMER STOCKHOLDERS
OF ACCESS ONCOLOGY UPON ACHIEVEMENT OF CERTAIN MILESTONES

FOR the issuance of up to WITHHOLD AUTHORITY
3,372,422 shares of
Keryx common stock to the
former stockholders
of ACCESS Oncology, Inc.
(in lieu of cash [ ]
having an equivalent
value that will otherwise
be deliverable)
[ ]

PROPOSAL THREE: APPROVAL OF OUR 2004 LONG-TERM INCENTIVE PLAN

FOR the approval of our WITHHOLD AUTHORITY
2004
Long-Term Incentive Plan [ ]
[ ]

PROPOSAL FOUR: APPROVAL OF THE DELISTING OF OUR COMMON STOCK
FROM THE ALTERNATIVE INVESTMENT MARKET OF THE LONDON STOCK EXCHANGE

FOR the approval of the WITHHOLD AUTHORITY
delisting of our common
stock from the [ ]
Alternative Investment
Market
[ ]

PROPOSAL FIVE: APPROVAL OF AMENDMENT OF CERTIFICATE OF INCORPORATION

TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF OUR COMMON STOCK

FOR the approval of the WITHHOLD AUTHORITY
amendment of our
certificate of [ ]
incorporation to increase
the number of authorized
shares of our common
stock
[ ]

A-2

THE APPROVAL OF OUR 2004 LONG-TERM INCENTIVE PLAN, "FOR" THE DELISTING OF OUR
COMMON STOCK FROM THE ALTERNATIVE INVESTMENT MARKET OF THE LONDON STOCK
EXCHANGE, AND "FOR" THE AMENDMENT OF OUR CERTIFICATE OF INCORPORATION TO
INCREASE THE NUMBER OF AUTHORIZED SHARES OF OUR COMMON STOCK.

--------------------------------------------------------------------------------

The undersigned stockholder of Keryx Biopharmaceuticals, Inc. hereby appoints
Michael S. Weiss, Chief Executive Officer of Keryx Biopharmaceuticals, Inc. and
Ron Bentsur, Secretary of Keryx Biopharmaceuticals, Inc., with full power of
substitution, as proxies to vote the shares of common stock that the undersigned
could vote if personally present at the Annual Meeting of Stockholders of Keryx
Biopharmaceuticals, Inc. to be held at the offices of the Company's legal
counsel, Alston & Bird LLP, located at 90 Park Avenue, New York, New York 10016,
on June 10, 2004, at 10:00 a.m., local time, or any adjournment thereof.

SIGNATURE DATED
---------------------------------- -------------------------
DATED
---------------------------------- -------------------------

Note: Please date and sign exactly as your name appears on the envelope in which
this material was mailed. If shares are held jointly, each stockholder
must sign. Executors, administrators, trustees, etc. should use his or her
full title, and if there is more than one, each individual must sign. If
the stockholder is a corporation, please sign the full corporate name by
an authorized officer. If the stockholder is a partnership, please sign
the full partnership name by an authorized person.

A-3

ANNEX B

AMENDED AND RESTATED AUDIT COMMITTEE CHARTER

B-1

ANNEX B

KERYX BIOPHARMACEUTICALS, INC.

AMENDED AND RESTATED AUDIT COMMITTEE CHARTER

I. PURPOSE AND AUTHORITY.

The Audit Committee (the "Committee") is a committee appointed by the Board
of Directors of Keryx Biopharmaceuticals, Inc. (the "Company"). Its primary
function is to assist the Board of Directors in overseeing (1) the accounting
and financial reporting processes of the Company, and (2) the audits of the
financial statements of the Company.

The Committee also prepares a written report to be included in the annual
proxy statement of the Company pursuant to the applicable rules and regulations
of the Securities and Exchange Commission (the "SEC").

In furtherance of these purposes, the Committee shall maintain direct
communication among the Company's independent auditors and the Board of
Directors. The independent auditors and any other registered public accounting
firm engaged for the purpose of preparing or issuing an audit report or
performing other audit review or attest services for the Company shall report
directly to the Committee and are ultimately accountable to the Committee and
the Board of Directors.

In discharging its oversight role, the Committee is empowered to
investigate any matter brought to its attention with full access to all books,
records, facilities and personnel of the Company. The Committee shall have the
sole authority to retain at the Company's expense outside legal, accounting or
other advisors to advise the Committee and to receive appropriate funding, as
determined by the Committee, from the Company for the payment of the
compensation of such advisors and for the payment of ordinary administrative
expenses of the Committee that are necessary to carry out its duties. The
Committee may request any officer or employee of the Company or the Company's
outside counsel or independent auditors to attend a meeting of the Committee or
to meet with any member of, or advisors to, the Committee. The Committee may
also meet with the Company's investment bankers or financial analysts who follow
the Company.

II. COMPOSITION OF THE COMMITTEE.

The Board of Directors shall appoint the members of the Committee. The
membership of the Committee shall be governed by the following requirements:

- It must consist of at least three members of the Board of Directors, all
of whom shall meet the independence and experience requirements in
accordance with applicable laws, including the rules and regulations of
the SEC and the Nasdaq National Market ("Nasdaq").

- No member of the Committee shall have participated in the preparation of
the financial statements of the Company or any current subsidiary of the
Company at any time during the past three years.

- At least one member of the Committee shall be an "audit committee
financial expert" within the meaning set forth by the rules of the SEC.

- Each member must be able to read and understand fundamental financial
statements, including the Company's balance sheet, income statement and
cash flow statement.

- At least one member of the Committee must have past employment experience
in finance or accounting, requisite professional certification in
accounting, or any other comparable experience or background which
results in such member's financial sophistication, including being or
having been a chief executive officer, chief financial officer or other
senior officer with financial oversight responsibilities.

The Chairman of the Committee shall be designated by the Board of
Directors. In the absence of the Chairman, the members of the Committee may
designate a chairman by majority vote. The Board of

B-2

Directors may, at any time, remove one or more directors as members of the
Committee. The Board of Directors may designate one or more members of the Board
as alternative members of the Committee, who may replace any absent or
disqualified member or members at any meetings of the Committee. In addition, no
person may be made a member of the Committee if his or her service on the
Committee would violate any restrictions imposed by any rules of the SEC, Nasdaq
or any other exchange on which shares of the common stock of the Company are
traded.

III. MEETINGS OF THE COMMITTEE.

The Committee shall meet no less frequently than four times per year, with
additional meetings as circumstances warrant. Members of the Committee are to be
present, in person or telephonically, at all meetings. The Committee shall also
meet periodically with management, the internal auditors, if any, and the
independent auditors in separate executive sessions. The Committee shall record
the minutes of all such meetings and shall submit the minutes of its meetings
to, or discuss the matters deliberated at each meeting with, the Board of
Directors. The Company's chief financial or accounting officer shall function as
the management liaison officer to the Committee.

IV. RESPONSIBILITIES OF THE COMMITTEE.

A. DOCUMENT/REPORT REVIEW

1. Review the Audit Committee Charter and the performance of the Committee
at least annually, and update the Audit Committee Charter as conditions dictate.

2. Review and discuss with management and the independent auditors the
Company's annual and quarterly financial statements and related footnotes and
any reports or other financial information submitted to the Company's
stockholders, any governmental body, or the public, including any certification,
report, opinion, or review rendered by the independent auditors.

3. Meet quarterly with financial management and with the independent
auditors to discuss:

a. The annual audited financial statements and the quarterly financial
statements prior to any SEC filings, including, in each case, a review of
the Company's disclosures under "Management's Discussion and Analysis of
Financial Condition and Results of Operations."

b. The type and presentation of information included in press releases
of unaudited interim and annual financial results, including, without
limitation, the use of "pro forma" or other "adjusted" financial
information not prepared in accordance with generally accepted accounting
principles.

c. The type and presentation of financial information and earnings
guidance provided to analysts and ratings agencies.

4. Recommend to management whether or not the Company should include its
financial statements in its annual report on Form 10-K, based on the Committee's
review of the Company's financial statements, its discussions with the
independent auditors of the Company's accounting practices and its discussions
with the outside accountant concerning independence of the outside accountant.

5. Disclose, as required by the applicable securities laws, in the
Company's proxy statement or annual report on Form 10-K, the formal written
report of the Committee and all other required information concerning the
Committee and its function.

6. Review, in consultation with management, the Company's policies with
respect to risk assessment and risk management.

7. Discuss, prior to any public release or filing, the Company's earnings
press releases, as well as financial information and earnings guidance provided
to analysts and rating agencies.

B-3

B. INDEPENDENT ACCOUNTANTS

1. In the Committee's sole discretion, control the retention, compensation,
evaluation and oversight of the independent accountants, considering their
independence and effectiveness, and determine the fees and other compensation to
be paid to the independent accountants.

2. Advise the independent accountants that they are ultimately accountable
to Board of Directors and the Committee, as representatives of the stockholders.

3. On an annual basis, receive from the independent accountants the formal
written disclosure and letter required by Independence Standards Board Standard
No. 1, and discuss with the independent accountants all significant
relationships the accountants have with the Company that may impact the
objectivity and independence of the independent accountant.

4. Review with the independent accountants at a time when the annual audit
plan is being developed, the plan's timing, scope, staffing, locations,
foreseeable issues, priorities and procedures and help to coordinate the
execution of the plan.

5. Take appropriate action to oversee the independence of the independent
accountants, including review and approval of any terms of any audit or
non-audit engagements with the independent accountants.

6. Review the performance of the independent accountants and recommend
discharge of the independent accountants when circumstances warrant.

7. Periodically consult with the independent accountants, out of the
presence of management, about (a) the adequacy and effectiveness of the
Company's internal controls, (b) the fullness and accuracy of the organization's
financial statements, (c) the adequacy and effectiveness of the Company's
disclosure controls and procedures, (d) the Company's internal audit procedures,
and (e) any related significant findings and recommendations of the independent
accountants together with management's responses thereto.

8. At least annually, obtain, review, and report to the full Board of
Directors the results of the Committee's review of, a report from the
independent accountants describing (a) the independent accountants' internal
quality control procedures, (b) any material issues raised by the most recent
internal quality-control review, or peer review, of the independent accountants
or by any inquiry or investigation by governmental or professional authorities
within the preceding five years concerning any of the independent audits carried
out by the independent accountants, as well as the steps taken to deal with such
issues, and (c) all relationships between the Company and the independent
accountants.

9. Establish clear hiring policies relating to the retention by the Company
of current or former employees of the independent accountants.

C. FINANCIAL REPORTING PROCESSES

1. In consultation with the independent accountants, review the integrity
of the Company's internal and external financial reporting processes.

2. Consult with the independent accountants and management about the
independent accountants' judgments concerning not only the acceptability, but
also the quality and appropriateness of the Company's accounting principles as
applied in its financial reporting.

3. Consider and approve, if appropriate, major changes to the Company's
auditing and accounting principles and practices as suggested by the independent
accountants or management.

D. PROCESS IMPROVEMENT

1. Establish regular and separate systems of reporting to the Committee by
each of management and the independent accountants regarding any significant
judgments made in management's preparation of the financial statements and the
view of each as to the appropriateness of such judgment.

B-4

2. Following completion of the annual audit, review separately with each of
management and the independent accountants any significant difficulties
encountered during the course of the audit, including any restrictions on the
scope of work or access to required information and any other matters related to
the conduct of the audit that are to be communicated to the Committee under
generally accepted auditing standards.

3. Review any significant disagreement among management and the independent
accountants in connection with the preparation of the financial statements.

4. Review with the independent accountants and management the extent to
which changes or improvements in financial or accounting practices, as approved
by the Committee, have been implemented. (This review should be conducted at an
appropriate time subsequent to implementation of changes or improvements, as
decided by the Committee).

5. Report annually to the Board of Directors, after the close of each
fiscal year but prior to the Company's annual meeting of stockholders, as well
as on any other appropriate occasion, any material issues that arise with
respect to the quality or integrity of the Company's financial statements, the
Company's compliance with legal and regulatory requirements, the performance and
independence of the independent accountants, the performance of the internal
audit function, if any, and whatever else the Committee deems appropriate.

E. ETHICAL AND LEGAL COMPLIANCE

1. Establish, review and update periodically a code of ethical conduct and
ensure that management has established a system to enforce this code.

2. Review management's monitoring of the Company's compliance with the
Company's code of ethical conduct, and ensure that management has the proper
review system in place to ensure that the Company's financial statements,
reports and other financial information disseminated to governmental
organizations and the public satisfy legal requirements.

3. Establish procedures for (a) the receipt, retention, and treatment of
complaints received by the Company regarding accounting, internal accounting
controls, and auditing matters, and (b) the confidential, anonymous submission
by employees of the Company of concerns regarding questionable accounting or
auditing matters.

4. Conduct an appropriate review of all related party transactions for
potential conflict of interest situations and approve all related party
transactions. For purposes hereof, the term "related party transaction" shall
refer to the transactions required to be disclosed pursuant to the SEC's Item
404 of Regulation S-K.

5. Conduct or authorize investigations into any matters within the
Committee's scope of responsibilities and retain special independent legal,
accounting or other advisors to advise the Committee as necessary to carry out
its duties.

6. Review, with Company outside counsel, any legal matter that could have a
significant impact on the Company's financial statements.

7. Perform any other activities consistent with the Audit Committee
Charter, the Company's Bylaws and governing law, as the Committee or the Board
of Directors deems necessary or appropriate.

B-5

ANNEX C

2004 LONG-TERM INCENTIVE PLAN

KERYX BIOPHARMACEUTICALS, INC.

2004 LONG-TERM INCENTIVE PLAN

KERYX BIOPHARMACEUTICALS, INC.

2004 LONG-TERM INCENTIVE

ARTICLE 1 PURPOSE........................................................ 1
1.1 General..................................................... 1
ARTICLE 2 DEFINITIONS.................................................... 1
2.1 Definitions................................................. 1
ARTICLE 3 EFFECTIVE TERM OF PLAN......................................... 5
3.1 Effective Date.............................................. 5
3.2 Termination of Plan......................................... 5
ARTICLE 4 ADMINISTRATION................................................. 5
4.1 Committee................................................... 5
4.2 Actions and interpretations by the Committee................ 5
4.3 Authority of Committee...................................... 6
4.4 Award Certificates.......................................... 6
ARTICLE 5 SHARES SUBJECT TO THE PLAN..................................... 7
5.1 Number of Shares............................................ 7
5.2 Share Counting.............................................. 7
5.3 Stock Distributed........................................... 7
5.4 Limitation on Awards........................................ 7
ARTICLE 6 ELIGIBILITY.................................................... 7
6.1 General..................................................... 7
ARTICLE 7 STOCK OPTIONS.................................................. 7
7.1 General..................................................... 7
7.2 Incentive Stock Options..................................... 7
ARTICLE 8 STOCK APPRECIATION RIGHTS...................................... 9
8.1 Grant of Stock Appreciation Rights.......................... 9
ARTICLE 9 PERFORMANCE AWARDS............................................. 9
9.1 Grant of Performance Awards................................. 9
9.2 Performance Goals........................................... 9
9.3 Right to Payment............................................ 9
9.4 Other Terms................................................. 10
ARTICLE 10 RESTRICTED STOCK.............................................. 10
10.1 Grant of Restricted Stock................................... 10
10.2 Issuance and Restrictions................................... 10
10.3 Forfeiture.................................................. 10
10.4 Delivery of Restricted Stock................................ 10
ARTICLE 11 DIVIDEND EQUIVALENTS.......................................... 10
11.1 Grant of Dividend Equivalents............................... 10
ARTICLE 12 STOCK OR OTHER STOCK-BASED AWARDS............................. 11
12.1 Grant of Stock or Other Stock-Based Awards.................. 11

ARTICLE 13 PROVISIONS APPLICABLE TO AWARDS............................... 11
13.1 Stand-Alone, Tandem, and Substitute Awards.................. 11
13.2 Term of Awards.............................................. 11
13.3 Form of Payment of Awards................................... 11
13.4 Limits on Transfer.......................................... 11
13.5 Beneficiaries............................................... 11
13.6 Stock Certificates.......................................... 12
13.7 Acceleration upon a Change in Control....................... 12
13.8 Acceleration for Any Reason................................. 12
13.9 Effect of Acceleration...................................... 12
13.10 Qualified Performance-Based Awards.......................... 12
13.11 Termination of Employment................................... 14
ARTICLE 14 CHANGES IN CAPITAL STRUCTURE.................................. 14
14.1 General..................................................... 14
ARTICLE 15 AMENDMENT, MODIFICATION AND TERMINATION....................... 14
15.1 Amendment, Modification and Termination..................... 14
15.2 Awards Previously Granted................................... 15
ARTICLE 16 GENERAL PROVISIONS............................................ 15
16.1 No Rights to Awards; Non-Uniform Determinations............. 15
16.2 No Shareholder Rights....................................... 15
16.3 Withholding................................................. 15
16.4 No Right to Continued Service............................... 16
16.5 Unfunded Status of Awards................................... 16
16.6 Relationship to Other Benefits.............................. 16
16.7 Expenses.................................................... 16
16.8 Titles and Headings......................................... 16
16.9 Gender and Number........................................... 16
16.10 Fractional Shares........................................... 16
16.11 Government and Other Regulations............................ 16
16.12 Governing Law............................................... 17
16.13 Additional Provisions....................................... 17
16.14 No Limitations on Rights of Company......................... 17

KERYX BIOPHARMACEUTICALS, INC.

2004 LONG-TERM INCENTIVE PLAN

ARTICLE 1

PURPOSE

1.1. GENERAL. The purpose of the Keryx Biopharmaceuticals, Inc. 2004
Long-Term Incentive Plan (the "Plan") is to promote the success, and enhance the
value, of Keryx Biopharmaceuticals, Inc. (the "Company"), by linking the
personal interests of employees, officers, directors and consultants of the
Company or any Affiliate (as defined below) to those of Company shareholders and
by providing such persons with an incentive for outstanding performance. The
Plan is further intended to provide flexibility to the Company in its ability to
motivate, attract, and retain the services of employees, officers, directors and
consultants upon whose judgment, interest, and special effort the successful
conduct of the Company's operation is largely dependent. Accordingly, the Plan
permits the grant of incentive awards from time to time to selected employees,
officers, directors and consultants of the Company and its Affiliates.

ARTICLE 2

DEFINITIONS

2.1. DEFINITIONS. When a word or phrase appears in this Plan with the
initial letter capitalized, and the word or phrase does not commence a sentence,
the word or phrase shall generally be given the meaning ascribed to it in this
Section or in Section 1.1 unless a clearly different meaning is required by the
context. The following words and phrases shall have the following meanings:

(a) "Affiliate" means (i) any Subsidiary or Parent, or (ii) an entity
that directly or through one or more intermediaries controls, is controlled
by or is under common control with, the Company, as determined by the
Committee.

(b) "Award" means any Option, Stock Appreciation Right, Restricted
Stock or Restricted Stock Unit Award, Performance Award, Dividend
Equivalent Award, or Other Stock-Based Award, or any other right or
interest relating to Stock or cash, granted to a Participant under the
Plan.

(c) "Award Certificate" means a written document, in such form as the
Committee prescribes from time to time, setting forth the terms and
conditions of an Award.

(d) "Board" means the Board of Directors of the Company.

(e) "Change in Control" means and includes the occurrence of any one
of the following events:

(i) the acquisition by an individual, entity or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the 1934 Act) (a "Person") of
beneficial ownership of any capital stock of the Company if, after such
acquisition, such Person beneficially owns (within the meaning of Rule
13d-3 promulgated under the 1934 Act) 30% or more of either (x) the
then-outstanding shares of common stock of the Company (the "Outstanding
Company Common Stock") or (y) the combined voting power of the
then-outstanding securities of the Company entitled to vote generally in
the election of directors (the "Outstanding Company Voting Securities");
provided, however, that for purposes of this subsection (i), the
following acquisitions shall not constitute a Change in Control: (A) any
acquisition directly from the Company (excluding an acquisition pursuant
to the exercise, conversion or exchange of any security exercisable for,
convertible into or exchangeable for common stock or voting securities
of the Company, unless the Person exercising, converting or exchanging
such security acquired such security directly from the Company or an
underwriter or agent of the Company), (B) any acquisition by any
employee benefit plan (or related trust) sponsored or

C-1

maintained by the Company or any corporation controlled by the Company,
or (C) any acquisition by any corporation pursuant to a Business
Combination (as defined below) which complies with clauses (x) and (y)
of subsection (iii) of this definition, or (D) any acquisition by
Lindsay A. Rosenwald, Paramount Capital, Inc., or any entity controlled
by, controlled or under common control with Paramount Capital, Inc.
(each such party is referred to herein as an "Exempt Person") of any
shares of capital stock of the Company; provided that, after such
acquisition, such Exempt Person does not beneficially own more than 49%
of either (i) the Outstanding Company Common Stock or (ii) the
Outstanding Company Voting Securities; or

(ii) such time as the Continuing Directors (as defined below) do
not constitute a majority of the Board (or, if applicable, the Board of
Directors of a successor corporation to the Company), where the term
"Continuing Director" means at any date a member of the Board (x) who
was a member of the Board on the date of the initial adoption of this
Plan by the Board or (y) who was nominated or elected subsequent to such
date by at least a majority of the directors who were Continuing
Directors at the time of such nomination or election or whose election
to the Board was recommended or endorsed by at least a majority of the
directors who were Continuing Directors at the time of such nomination
or election; provided, however, that there shall be excluded from this
clause (y) any individual whose initial assumption of office occurred as
a result of an actual or threatened election contest with respect to the
election or removal of directors or other actual or threatened
solicitation of proxies or consents, by or on behalf of a person other
than the Board; or

(iii) the consummation of a merger, consolidation, reorganization,
recapitalization or share exchange involving the Company or a sale or
other disposition of all or substantially all of the assets of the
Company (a "Business Combination"), unless, immediately following such
Business Combination, each of the following two conditions is satisfied:
(x) all or substantially all of the individuals and entities who were
the beneficial owners of the Outstanding Company Common Stock and
Outstanding Company Voting Securities immediately prior to such Business
Combination beneficially own, directly or indirectly, more than 50% of
the then-outstanding shares of common stock and the combined voting
power of the then-outstanding securities entitled to vote generally in
the election of directors, respectively, of the resulting or acquiring
corporation in such Business Combination (which shall include, without
limitation, a corporation which as a result of such transaction owns the
Company or substantially all of the Company's assets either directly or
through one or more subsidiaries) (such resulting or acquiring
corporation is referred to herein as the "Acquiring Corporation") in
substantially the same proportions as their ownership of the Outstanding
Company Common Stock and Outstanding Company Voting Securities,
respectively, immediately prior to such Business Combination and (y) no
Person (excluding Exempt Persons, the Acquiring Corporation or any
employee benefit plan (or related trust) maintained or sponsored by the
Company or by the Acquiring Corporation) beneficially owns, directly or
indirectly, 30% or more of the then-outstanding shares of common stock
of the Acquiring Corporation, or of the combined voting power of the
then-outstanding securities of such corporation entitled to vote
generally in the election of directors (except to the extent that such
ownership existed prior to the Business Combination).

(f) "Code" means the Internal Revenue Code of 1986, as amended from
time to time.

(g) "Committee" means the committee of the Board described in Article
4.

(h) "Company" means Keryx Biopharmaceuticals, Inc., a Delaware
corporation.

(i) "Continuous Status as a Participant" means the absence of any
interruption or termination of service as an employee, officer, consultant
or director of the Company or any Affiliate, as applicable; provided,
however, that for purposes of an Incentive Stock Option, or a Stock
Appreciation Right issued in tandem with an Incentive Stock Option,
"Continuous Status as a Participant" means the absence of any interruption
or termination of service as an employee of the Company or any Parent or
Subsidiary, as applicable. Continuous Status as a Participant shall
continue to the extent provided in a written severance or employment
agreement during any period for which severance compensation payments are
made to an

C-2

employee, officer, consultant or director and shall not be considered
interrupted in the case of any leave of absence authorized in writing by
the Company prior to its commencement.

(j) "Covered Employee" means a covered employee as defined in Code
Section 162(m)(3).

(k) "Disability" or "Disabled" has the same meaning as provided in the
long-term disability plan or policy maintained by the Company or if
applicable, most recently maintained, by the Company or if applicable, an
Affiliate, for the Participant, whether or not such Participant actually
receives disability benefits under such plan or policy. If no long-term
disability plan or policy was ever maintained on behalf of Participant or
if the determination of Disability relates to an Incentive Stock Option, or
a Stock Appreciation Right issued in tandem with an Incentive Stock Option,
Disability means Permanent and Total Disability as defined in Section
22(e)(3) of the Code. In the event of a dispute, the determination whether
a Participant is Disabled will be made by the Committee and may be
supported by the advice of a physician competent in the area to which such
Disability relates.

(l) "Dividend Equivalent" means a right granted to a Participant under
Article 11.

(m) "Effective Date" has the meaning assigned such term in Section
3.1.

(n) "Eligible Participant" means an employee, officer, consultant or
director of the Company or any Affiliate.

(o) "Exchange" means the Nasdaq National Market or any national
securities exchange on which the Stock may from time to time be listed or
traded.

(p) "Fair Market Value", on any date, means (i) if the Stock is listed
on a securities exchange or is traded over the Nasdaq National Market, the
closing sales price on such exchange or over such system on such date or,
in the absence of reported sales on such date, the closing sales price on
the immediately preceding date on which sales were reported, or (ii) if the
Stock is not listed on a securities exchange or traded over the Nasdaq
National Market, the mean between the bid and offered prices as quoted by
Nasdaq for such date, provided that if it is determined that the fair
market value is not properly reflected by such Nasdaq quotations, Fair
Market Value will be determined by such other method as the Committee
determines in good faith to be reasonable.

(q) "Grant Date" means the date an Award is made by the Committee.

(r) "Incentive Stock Option" means an Option that is intended to be an
incentive stock option and meets the requirements of Section 422 of the
Code or any successor provision thereto.

(s) "Non-Employee Director" means a director of the Company who is not
a common law employee of the Company or an Affiliate.

(t) "Nonstatutory Stock Option" means an Option that is not an
Incentive Stock Option.

(u) "Option" means a right granted to a Participant under Article 7 of
the Plan to purchase Stock at a specified price during specified time
periods. An Option may be either an Incentive Stock Option or a
Nonstatutory Stock Option.

(v) "Other Stock-Based Award" means a right, granted to a Participant
under Article 12, that relates to or is valued by reference to Stock or
other Awards relating to Stock.

(w) "Parent" means a corporation, limited liability company,
partnership or other entity which owns or beneficially owns a majority of
the outstanding voting stock or voting power of the Company.
Notwithstanding the above, with respect to an Incentive Stock Option,
Parent shall have the meaning set forth in Section 424(e) of the Code.

(x) "Participant" means a person who, as an employee, officer,
director or consultant of the Company or any Affiliate, has been granted an
Award under the Plan; provided that in the case of the death of a
Participant, the term "Participant" refers to a beneficiary designated
pursuant to Section 13.5

C-3

or the legal guardian or other legal representative acting in a fiduciary
capacity on behalf of the Participant under applicable state law and court
supervision.

(y) "Performance Award" means Performance Shares or Performance Units
granted pursuant to Article 9.

(aa) "Performance Share" means any right granted to a Participant
under Article 9 to a unit to be valued by reference to a designated
number of Shares to be paid upon achievement of such performance goals
as the Committee establishes with regard to such Performance Share.

(bb) "Performance Unit" means a right granted to a Participant
under Article 9 to a unit valued by reference to a designated amount of
cash or property other than Shares, to be paid to the Participant upon
achievement of such performance goals as the Committee establishes with
regard to such Performance Unit.

(cc) "Person" means any individual, entity or group, within the
meaning of Section 3(a)(9) of the 1934 Act and as used in Section
13(d)(3) or 14(d)(2) of the 1934 Act.

(dd) "Plan" means the Keryx Biopharmaceuticals, Inc. 2004 Long-Term
Incentive Plan, as amended from time to time.

(ee) "Qualified Performance-Based Award" means an award that is
either (i) a Performance Award, Restricted Stock Award, Dividend
Equivalent, Other Stock-Based Award or cash incentive award that is
intended to qualify for the Section 162(m) Exemption and is made subject
to performance goals based on Qualified Business Criteria as set forth
in Section 13.10, or (ii) an Option or SAR having an exercise price
equal to or greater than the Fair Market Value of the underlying Stock
as of the Grant Date.

(ff) "Qualified Business Criteria" means one or more of the
Business Criteria listed in Section 13.10(b) upon which performance
goals for certain Qualified Performance-Based Awards may be established
by the Committee.

(gg) "Restricted Stock Award" means Stock granted to a Participant
under Article 10 that is subject to certain restrictions and to risk of
forfeiture.

(hh) "Restricted Stock Unit Award" means the right to receive
shares of Stock in the future, granted to a Participant under Article
10.

(ii) "Retirement" means a Participant's termination of employment
with the Company or an Affiliate with the Committee's approval after
attaining any normal or early retirement age specified in any pension,
profit sharing or other retirement program sponsored by the Company, or,
in the event of the inapplicability thereof with respect to the
Participant in question, as determined by the Committee in its
reasonable judgment.

(jj) "Section 162(m) Exemption" means the exemption from the
limitation on deductibility imposed by Section 162(m) of the Code that
is set forth in Section 162(m)(4)(C) of the Code or any successor
provision thereto.

(kk) "Shares" means shares of the Company's Stock. If there has
been an adjustment or substitution pursuant to Section 14.1, the term
"Shares" shall also include any shares of stock or other securities that
are substituted for Shares or into which Shares are adjusted pursuant to
Section 14.1.

(ll) "Stock" means the $0.001 par value common stock of the Company
and such other securities of the Company as may be substituted for Stock
pursuant to Article 14.

(mm) "Stock Appreciation Right" or "SAR" means a right granted to a
Participant under Article 8 to receive a payment equal to the difference
between the Fair Market Value of a Share as of the date of exercise of
the SAR over the grant price of the SAR, all as determined pursuant to
Article 8.

C-4

(nn) "Subsidiary" means any corporation, limited liability company,
partnership or other entity of which a majority of the outstanding
voting stock or voting power is beneficially owned directly or
indirectly by the Company. Notwithstanding the above, with respect to an
Incentive Stock Option, Subsidiary shall have the meaning set forth in
Section 424(f) of the Code.

(oo) "1933 Act" means the Securities Act of 1933, as amended from
time to time.

(pp) "1934 Act" means the Securities Exchange Act of 1934, as
amended from time to time.

ARTICLE 3

EFFECTIVE TERM OF PLAN

3.1. EFFECTIVE DATE. The Plan shall be effective as of the date it is
approved by both the Board and the shareholders of the Company (the "Effective
Date").

3.2. TERMINATION OF PLAN. The Plan shall terminate on the tenth
anniversary of the Effective Date. The termination of the Plan on such date
shall not affect the validity of any Award outstanding on the date of
termination.

ARTICLE 4

ADMINISTRATION

4.1. COMMITTEE. The Plan shall be administered by a Committee appointed
by the Board (which Committee shall consist of at least two directors) or, at
the discretion of the Board from time to time, the Plan may be administered by
the Board. It is intended that at least two of the directors appointed to serve
on the Committee shall be "non-employee directors" (within the meaning of Rule
16b-3 promulgated under the 1934 Act) and "outside directors" (within the
meaning of Code Section 162(m) and the regulations thereunder) and that any such
members of the Committee who do not so qualify shall abstain from participating
in any decision to make or administer Awards that are made to Eligible
Participants who at the time of consideration for such Award are, or who are
anticipated to be become, either (i) Covered Employees or (ii) persons subject
to the short-swing profit rules of Section 16 of the 1934 Act. However, the mere
fact that a Committee member shall fail to qualify under either of the foregoing
requirements or shall fail to abstain from such action shall not invalidate any
Award made by the Committee which Award is otherwise validly made under the
Plan. The members of the Committee shall be appointed by, and may be changed at
any time and from time to time in the discretion of, the Board. The Board may
reserve to itself any or all of the authority and responsibility of the
Committee under the Plan or may act as administrator of the Plan for any and all
purposes. To the extent the Board has reserved any authority and responsibility
or during any time that the Board is acting as administrator of the Plan, it
shall have all the powers of the Committee hereunder, and any reference herein
to the Committee (other than in this Section 4.1) shall include the Board. To
the extent any action of the Board under the Plan conflicts with actions taken
by the Committee, the actions of the Board shall control.

4.2. ACTION AND INTERPRETATIONS BY THE COMMITTEE. For purposes of
administering the Plan, the Committee may from time to time adopt rules,
regulations, guidelines and procedures for carrying out the provisions and
purposes of the Plan and make such other determinations, not inconsistent with
the Plan, as the Committee may deem appropriate. The Committee's interpretation
of the Plan, any Awards granted under the Plan, any Award Certificate and all
decisions and determinations by the Committee with respect to the Plan are
final, binding, and conclusive on all parties. Each member of the Committee is
entitled to, in good faith, rely or act upon any report or other information
furnished to that member by any officer or other employee of the Company or any
Affiliate, the Company's or an Affiliate's independent certified public
accountants, Company counsel or any executive compensation consultant or other
professional retained by the Company to assist in the administration of the
Plan.

C-5

4.3. AUTHORITY OF COMMITTEE. Except as provided below, the Committee has
the exclusive power, authority and discretion to:

(a) Grant Awards;

(b) Designate Participants;

(d) Determine the number of Awards to be granted and the number of
Shares or dollar amount to which an Award will relate;

(e) Determine the terms and conditions of any Award granted under the
Plan, including but not limited to, the exercise price, grant price, or
purchase price, any restrictions or limitations on the Award, any schedule
for lapse of forfeiture restrictions or restrictions on the exercisability
of an Award, and accelerations or waivers thereof, based in each case on
such considerations as the Committee in its sole discretion determines;

(f) Accelerate the vesting, exercisability or lapse of restrictions of
any outstanding Award, in accordance with Article 13, based in each case on
such considerations as the Committee in its sole discretion determines;

(g) Determine whether, to what extent, and under what circumstances an
Award may be settled in, or the exercise price of an Award may be paid in,
cash, Stock, other Awards, or other property, or an Award may be canceled,
forfeited, or surrendered;

(h) Prescribe the form of each Award Certificate, which need not be
identical for each Participant;

(i) Decide all other matters that must be determined in connection
with an Award;

(j) Establish, adopt or revise any rules, regulations, guidelines or
procedures as it may deem necessary or advisable to administer the Plan;

(k) Make all other decisions and determinations that may be required
under the Plan or as the Committee deems necessary or advisable to
administer the Plan;

(l) Amend the Plan or any Award Certificate as provided herein; and

(m) Adopt such modifications, procedures, and subplans as may be
necessary or desirable to comply with provisions of the laws of non-U.S.
jurisdictions in which the Company or any Affiliate may operate, in order
to assure the viability of the benefits of Awards granted to participants
located in such other jurisdictions and to meet the objectives of the Plan.

Notwithstanding the above, the Board may expressly delegate to a special
committee consisting of one or more officers of the Company some or all of the
Committee's authority under subsections (a) through (i) above, except that no
delegation of its duties and responsibilities may be made to officers of the
Company with respect to Awards to Eligible Participants who as of the Grant Date
are persons subject to the short-swing profit rules of Section 16 of the 1934
Act, or who as of the Grant Date are reasonably anticipated to be become Covered
Employees during the term of the Award. The acts of such delegates shall be
treated hereunder as acts of the Committee, and such delegates shall report to
the Committee regarding the delegated duties and responsibilities.

4.4. AWARD CERTIFICATES. Each Award shall be evidenced by an Award
Certificate. Each Award Certificate shall include such provisions, not
inconsistent with the Plan, as may be specified by the Committee.

C-6

ARTICLE 5

SHARES SUBJECT TO THE PLAN

5.1. NUMBER OF SHARES. Subject to adjustment as provided in Sections 5.2
and 14.1, the aggregate number of Shares reserved and available for issuance
pursuant to Awards granted under the Plan shall be 4,000,000.

5.2. SHARE COUNTING.

(a) To the extent that an Award is canceled, terminates, expires, is
forfeited or lapses for any reason, any unissued Shares subject to the
Award will again be available for issuance pursuant to Awards granted under
the Plan.

(b) Shares subject to Awards settled in cash will again be available
for issuance pursuant to Awards granted under the Plan.

(c) If the exercise price of an Option is satisfied by delivering
Shares to the Company (by either actual delivery or attestation), only the
number of Shares issued in excess of the delivery or attestation shall be
considered for purposes of determining the number of Shares remaining
available for issuance pursuant to Awards granted under the Plan.

(d) To the extent that the full number of Shares subject to an Option
is not issued upon exercise of the Option for any reason (other than Shares
used to satisfy an applicable tax withholding obligation), only the number
of Shares issued and delivered upon exercise of the Option shall be
considered for purposes of determining the number of Shares remaining
available for issuance pursuant to Awards granted under the Plan. Nothing
in this subsection shall imply that any particular type of cashless
exercise of an Option is permitted under the Plan, that decision being
reserved to the Committee or other provisions of the Plan.

5.3. STOCK DISTRIBUTED. Any Stock distributed pursuant to an Award may
consist, in whole or in part, of authorized and unissued Stock, treasury Stock
or Stock purchased on the open market.

5.4. LIMITATION ON AWARDS. Notwithstanding any provision in the Plan to
the contrary (but subject to adjustment as provided in Section 14.1), the
maximum number of Shares with respect to one or more Options and/or SARs that
may be granted during any one calendar year under the Plan to any one
Participant shall be 4,000,000. The aggregate maximum fair market value
(measured as of the Grant Date) of any Awards other than Options and SARs that
may be granted to any one Participant (less any consideration paid by the
Participant for such Award) during any one calendar year under the Plan shall be
$5,000,000.00.

ARTICLE 6

ELIGIBILITY

6.1. GENERAL. Awards may be granted only to Eligible Participants; except
that Incentive Stock Options may be granted to only to Eligible Participants who
are employees of the Company or a Parent or Subsidiary as defined in Section
424(e) and (f) of the Code.

ARTICLE 7

STOCK OPTIONS

7.1. GENERAL. The Committee is authorized to grant Options to
Participants on the following terms and conditions:

(a) EXERCISE PRICE. The exercise price per Share under an Option
shall be determined by the Committee.

(b) TIME AND CONDITIONS OF EXERCISE. The Committee shall determine
the time or times at which an Option may be exercised in whole or in part,
subject to Section 7.1(d). The Committee shall also determine the
performance or other conditions, if any, that must be satisfied before all
or part of

C-7

an Option may be exercised or vested. Subject to Section 13.8, the
Committee may waive any exercise or vesting provisions at any time in whole
or in part based upon factors as the Committee may determine in its sole
discretion so that the Option becomes exercisable or vested at an earlier
date.

(c) PAYMENT. The Committee shall determine the methods by which the
exercise price of an Option may be paid, the form of payment, including,
without limitation, cash, Shares, or other property (including "cashless
exercise" arrangements), and the methods by which Shares shall be delivered
or deemed to be delivered to Participants; provided, however, that if
Shares are used to pay the exercise price of an Option, such Shares must
have been held by the Participant for at least such period of time, if any,
as necessary to avoid variable accounting for the Option.

(d) EXERCISE TERM. In no event may any Option be exercisable for more
than ten years from the Grant Date.

7.2. INCENTIVE STOCK OPTIONS. The terms of any Incentive Stock Options
granted under the Plan must comply with the following additional rules:

(a) EXERCISE PRICE. The exercise price of an Incentive Stock Option
shall not be less than the Fair Market Value as of the Grant Date.

(b) LAPSE OF OPTION. An Incentive Stock Option shall lapse upon the
earliest of the following circumstances, or such earlier event as may be
provided in the relevant Award Certificate; provided, however, that the
Committee may, prior to the lapse of the Incentive Stock Option under the
circumstances described in subsections (3), (4) or (5) below, provide in
writing that the Option will extend until a later date, but if an Option is
so extended and is exercised after the dates specified in subsections (3)
and (4) below, it will automatically become a Nonstatutory Stock Option:

(1) The expiration date set forth in the Award Certificate.

(2) The tenth anniversary of the Grant Date.

(3) Three months after termination of the Participant's Continuous
Status as a Participant for any reason other than the Participant's
Disability or death.

(4) One year after the Participant's Continuous Status as a
Participant by reason of the Participant's Disability.

(5) One year after the termination of the Participant's death if
the Participant dies while employed, or during the three-month period
described in paragraph (3) or during the one-year period described in
paragraph (4) and before the Option otherwise lapses.

Unless the exercisability of the Incentive Stock Option is accelerated
as provided in Article 13, if a Participant exercises an Option after
termination of employment, the Option may be exercised only with respect to
the Shares that were otherwise vested on the Participant's termination of
employment. Upon the Participant's death, any exercisable Incentive Stock
Options may be exercised by the Participant's beneficiary, determined in
accordance with Section 13.5.

(c) INDIVIDUAL DOLLAR LIMITATION. The aggregate Fair Market Value
(determined as of the Grant Date) of all Shares with respect to which
Incentive Stock Options are first exercisable by a Participant in any
calendar year may not exceed $100,000.00.

(d) TEN PERCENT OWNERS. No Incentive Stock Option shall be granted to
any individual who, at the Grant Date, owns stock possessing more than ten
percent of the total combined voting power of all classes of stock of the
Company or any Parent or Subsidiary unless the exercise price per share of
such Option is at least 110% of the Fair Market Value per Share at the
Grant Date and the Option expires no later than five years after the Grant
Date.

(e) EXPIRATION OF AUTHORITY TO GRANT INCENTIVE STOCK OPTIONS. No
Incentive Stock Option may be granted pursuant to the Plan after the day
immediately prior to the tenth anniversary of the date the Plan was adopted
by the Board, or the termination of the Plan, if earlier.

C-8

(f) RIGHT TO EXERCISE. During a Participant's lifetime, an Incentive
Stock Option may be exercised only by the Participant or, in the case of
the Participant's Disability, by the Participant's guardian or legal
representative.

(g) ELIGIBLE GRANTEES. The Committee may not grant an Incentive Stock
Option to a person who is not at the Grant Date an employee of the Company
or a Parent or Subsidiary.

ARTICLE 8

STOCK APPRECIATION RIGHTS

8.1. GRANT OF STOCK APPRECIATION RIGHTS. The Committee is authorized to
grant Stock Appreciation Rights to Participants on the following terms and
conditions:

(a) RIGHT TO PAYMENT. Upon the exercise of a Stock Appreciation
Right, the Participant to whom it is granted has the right to receive the
excess, if any, of:

(1) The Fair Market Value of one Share on the date of exercise;
over

(2) The grant price of the Stock Appreciation Right as determined
by the Committee, which shall not be less than the Fair Market Value of
one Share on the Grant Date in the case of any Stock Appreciation Right
related to an Incentive Stock Option.

(b) OTHER TERMS. All awards of Stock Appreciation Rights shall be
evidenced by an Award Certificate. The terms, methods of exercise, methods
of settlement, form of consideration payable in settlement, and any other
terms and conditions of any Stock Appreciation Right shall be determined by
the Committee at the time of the grant of the Award and shall be reflected
in the Award Certificate.

ARTICLE 9

PERFORMANCE AWARDS

9.1. GRANT OF PERFORMANCE AWARDS. The Committee is authorized to grant
Performance Shares or Performance Units to Participants on such terms and
conditions as may be selected by the Committee. The Committee shall have the
complete discretion to determine the number of Performance Shares or Performance
Units granted to each Participant, subject to Section 5.4, and to designate the
provisions of such Performance Awards as provided in Section 4.3.

9.2. PERFORMANCE GOALS. The Committee may establish performance goals for
Performance Awards which may be based on any criteria selected by the Committee.
Such performance goals may be described in terms of Company-wide objectives or
in terms of objectives that relate to the performance of the Participant, an
Affiliate or a division, region, department or function within the Company or an
Affiliate. If the Committee determines that a change in the business,
operations, corporate structure or capital structure of the Company or the
manner in which the Company or an Affiliate conducts its business, or other
events or circumstances render performance goals to be unsuitable, the Committee
may modify such performance goals in whole or in part, as the Committee deems
appropriate. If a Participant is promoted, demoted or transferred to a different
business unit or function during a performance period, the Committee may
determine that the performance goals or performance period are no longer
appropriate and may (i) adjust, change or eliminate the performance goals or the
applicable performance period as it deems appropriate to make such goals and
period comparable to the initial goals and period, or (ii) make a cash payment
to the participant in amount determined by the Committee. The foregoing two
sentences shall not apply with respect to a Performance Award that is intended
to be a Qualified Performance-Based Award.

9.3. RIGHT TO PAYMENT. The grant of a Performance Share to a Participant
will entitle the Participant to receive at a specified later time a specified
number of Shares, or the equivalent cash value, if the performance goals
established by the Committee are achieved and the other terms and conditions
thereof are satisfied. The grant of a Performance Unit to a Participant will
entitle the Participant to receive at a specified later time a specified dollar
value in cash or other property, including Shares, variable under conditions

C-9

specified in the Award, if the performance goals in the Award are achieved and
the other terms and conditions thereof are satisfied. The Committee shall set
performance goals and other terms or conditions to payment of the Performance
Awards in its discretion which, depending on the extent to which they are met,
will determine the number and value of the Performance Awards that will be paid
to the Participant.

9.4. OTHER TERMS. Performance Awards may be payable in cash, Stock, or
other property, and have such other terms and conditions as determined by the
Committee and reflected in the Award Certificate. For purposes of determining
the number of Shares to be used in payment of a Performance Award denominated in
cash but payable in whole or in part in Shares or Restricted Stock, the number
of Shares to be so paid will be determined by dividing the cash value of the
Award to be so paid by the Fair Market Value of a Share on the date of
determination by the Committee of the amount of the payment under the Award, or,
if the Committee so directs, the date immediately preceding the date the Award
is paid.

ARTICLE 10

RESTRICTED STOCK

10.1. GRANT OF RESTRICTED STOCK. The Committee is authorized to make
Awards of Restricted Stock or Restricted Stock Units to Participants in such
amounts and subject to such terms and conditions as may be selected by the
Committee. An Award of Restricted Stock or Restricted Stock Units shall be
evidenced by an Award Certificate setting forth the terms, conditions, and
restrictions applicable to the Award.

10.2. ISSUANCE AND RESTRICTIONS. Restricted Stock or Restricted Stock
Units shall be subject to such restrictions on transferability and other
restrictions as the Committee may impose (including, without limitation,
limitations on the right to vote Restricted Stock or the right to receive
dividends on the Restricted Stock). These restrictions may lapse separately or
in combination at such times, under such circumstances, in such installments,
upon the satisfaction of performance goals or otherwise, as the Committee
determines at the time of the grant of the Award or thereafter. Except as
otherwise provided in an Award Certificate, the Participant shall have all of
the rights of a shareholder with respect to the Restricted Stock, and the
Participant shall have none of the rights of a stockholder with respect to
Restricted Stock Units until such time as Shares of Stock are paid in settlement
of the Restricted Stock Units.

10.3. FORFEITURE. Except as otherwise determined by the Committee at the
time of the grant of the Award or thereafter, upon termination of Continuous
Status as a Participant during the applicable restriction period or upon failure
to satisfy a performance goal during the applicable restriction period,
Restricted Stock or Restricted Stock Units that are at that time subject to
restrictions shall be forfeited; provided, however, that the Committee may
provide in any Award Certificate that restrictions or forfeiture conditions
relating to Restricted Stock or Restricted Stock Units will be waived in whole
or in part in the event of terminations resulting from specified causes, and the
Committee may in other cases waive in whole or in part restrictions or
forfeiture conditions relating to Restricted Stock or Restricted Stock Units.

10.4. DELIVERY OF RESTRICTED STOCK. Shares of Restricted Stock shall be
delivered to the Participant at the time of grant either by book-entry
registration or by delivering to the Participant, or a custodian or escrow agent
(including, without limitation, the Company or one or more of its employees)
designated by the Committee, a stock certificate or certificates registered in
the name of the Participant. If physical certificates representing shares of
Restricted Stock are registered in the name of the Participant, such
certificates must bear an appropriate legend referring to the terms, conditions,
and restrictions applicable to such Restricted Stock.

ARTICLE 11

DIVIDEND EQUIVALENTS

11.1. GRANT OF DIVIDEND EQUIVALENTS. The Committee is authorized to grant
Dividend Equivalents to Participants subject to such terms and conditions as may
be selected by the Committee. Dividend Equivalents shall entitle the Participant
to receive payments equal to dividends with respect to all or

C-10

a portion of the number of Shares subject to an Award, as determined by the
Committee. The Committee may provide that Dividend Equivalents be paid or
distributed when accrued or be deemed to have been reinvested in additional
Shares, or otherwise reinvested.

ARTICLE 12

STOCK OR OTHER STOCK-BASED AWARDS

12.1. GRANT OF STOCK OR OTHER STOCK-BASED AWARDS. The Committee is
authorized, subject to limitations under applicable law, to grant to
Participants such other Awards that are payable in, valued in whole or in part
by reference to, or otherwise based on or related to Shares, as deemed by the
Committee to be consistent with the purposes of the Plan, including without
limitation Shares awarded purely as a "bonus" and not subject to any
restrictions or conditions, convertible or exchangeable debt securities, other
rights convertible or exchangeable into Shares, and Awards valued by reference
to book value of Shares or the value of securities of or the performance of
specified Parents or Subsidiaries. The Committee shall determine the terms and
conditions of such Awards.

ARTICLE 13

PROVISIONS APPLICABLE TO AWARDS

13.1. STAND-ALONE, TANDEM, AND SUBSTITUTE AWARDS. Awards granted under
the Plan may, in the discretion of the Committee, be granted either alone or in
addition to, in tandem with, or (subject to Section 15.2(c)) in substitution
for, any other Award granted under the Plan. If an Award is granted in
substitution for another Award, the Committee may require the surrender of such
other Award in consideration of the grant of the new Award. Awards granted in
addition to or in tandem with other Awards may be granted either at the same
time as or at a different time from the grant of such other Awards.

13.2. TERM OF AWARD. The term of each Award shall be for the period as
determined by the Committee, provided that in no event shall the term of any
Incentive Stock Option or a Stock Appreciation Right granted in tandem with the
Incentive Stock Option exceed a period of ten years from its Grant Date (or, if
Section 7.2(c) applies, five years from its Grant Date).

13.3. FORM OF PAYMENT FOR AWARDS. Subject to the terms of the Plan and
any applicable law or Award Certificate, payments or transfers to be made by the
Company or an Affiliate on the grant or exercise of an Award may be made in such
form as the Committee determines at or after the Grant Date, including without
limitation, cash, Stock, other Awards, or other property, or any combination,
and may be made in a single payment or transfer, in installments, or on a
deferred basis, in each case determined in accordance with rules adopted by, and
at the discretion of, the Committee.

13.4. LIMITS ON TRANSFER. No right or interest of a Participant in any
unexercised or restricted Award may be pledged, encumbered, or hypothecated to
or in favor of any party other than the Company or an Affiliate, or shall be
subject to any lien, obligation, or liability of such Participant to any other
party other than the Company, an Affiliate, or a member of the Participant's
immediate family, a trust for the benefit of the Participant or such family
members, or a partnership or other entities in which the Participant and such
family members are the only partners, shareholders, or owners (each a "Permitted
Transferee"). Unless otherwise specifically provided in an Award Certificate, no
unexercised or restricted Award shall be assignable or transferable by a
Participant other than (a) by will or the laws of descent and distribution or
(b) except in the case of an Incentive Stock Option, pursuant to a domestic
relations order that would satisfy Section 414(p)(1)(A) of the Code if such
Section applied to an Award under the Plan or (c) except in the case of (i) an
Incentive Stock Option or (ii) a Restricted Stock Award or other award for which
such transferability would result in accelerated taxation, to a Permitted
Transferee.

13.5. BENEFICIARIES. Notwithstanding Section 13.4, a Participant may, in
the manner determined by the Committee, designate a beneficiary to exercise the
rights of the Participant and to receive any distribution with respect to any
Award upon the Participant's death. A beneficiary, legal guardian, legal
representative, or other person claiming any rights under the Plan is subject to
all terms and conditions of the

C-11

Plan and any Award Certificate applicable to the Participant, except to the
extent the Plan and Award Certificate otherwise provide, and to any additional
restrictions deemed necessary or appropriate by the Committee. If no beneficiary
has been designated or survives the Participant, payment shall be made to the
Participant's estate. Subject to the foregoing, a beneficiary designation may be
changed or revoked by a Participant at any time provided the change or
revocation is filed with the Committee.

13.6. STOCK CERTIFICATES. All Stock issuable under the Plan is subject to
any stop-transfer orders and other restrictions as the Committee deems necessary
or advisable to comply with federal or state securities laws, rules and
regulations and the rules of any national securities exchange or automated
quotation system on which the Stock is listed, quoted, or traded. The Committee
may place legends on any Stock certificate or issue instructions to the transfer
agent to reference restrictions applicable to the Stock.

13.7. ACCELERATION UPON A CHANGE IN CONTROL. Except as otherwise provided
in the Award Certificate, or any special Plan document governing an Award, upon
the occurrence of a Change in Control, all outstanding Options, SARs, and other
Awards in the nature of rights that may be exercised shall become fully
exercisable, all restrictions on outstanding Awards shall lapse, and any
performance-based criteria with respect to outstanding Awards, other than
Qualified Performance-Based Awards, which are subject to Section 13.10, shall be
deemed to be satisfied at the greater of "target" or actual performance as of
the date of the Change in Control.

13.8. ACCELERATION FOR ANY REASON. Regardless of whether an event has
occurred as described in Section 13.7 above, the Committee may in its sole
discretion at any time determine that all or a portion of a Participant's
Options, SARs, and other Awards in the nature of rights that may be exercised
shall become fully or partially exercisable, that all or a part of the
restrictions on all or a portion of the outstanding Awards shall lapse, and/or
that any performance-based criteria with respect to any Awards shall be deemed
to be wholly or partially satisfied, in each case, as of such date as the
Committee may, in its sole discretion, declare. The Committee may discriminate
among Participants and among Awards granted to a Participant in exercising its
discretion pursuant to this Section 13.8.

13.9. EFFECT OF ACCELERATION. If an Award is accelerated under Section
13.7 or 13.8, the Committee may, in its sole discretion, provide (i) that the
Award will expire after a designated period of time after such acceleration to
the extent not then exercised, (ii) that the Award will be settled in cash
rather than Stock, (iii) that the Award will be assumed by another party to a
transaction giving rise to the acceleration or otherwise be equitably converted
or substituted in connection with such transaction, (iv) that the Award may be
settled by payment in cash or cash equivalents equal to the excess of the Fair
Market Value of the underlying Stock, as of a specified date associated with the
transaction, over the exercise price of the Award, or (v) any combination of the
foregoing. The Committee's determination need not be uniform and may be
different for different Participants whether or not such Participants are
similarly situated. To the extent that such acceleration causes Incentive Stock
Options to exceed the dollar limitation set forth in Section 7.2(b), the excess
Options shall be deemed to be Nonstatutory Stock Options.

13.10. QUALIFIED PERFORMANCE-BASED AWARDS.

(a) The provisions of the Plan are intended to ensure that all Options
and Stock Appreciation Rights granted hereunder to any Covered Employee
shall qualify for the Section 162(m) Exemption; provided that the exercise
or base price of such Award is not less than the Fair Market Value of the
Shares on the Grant Date.

(b) When granting any other Award, the Committee may designate such
Award as a Qualified Performance-Based Award, based upon a determination
that the recipient is or may be a Covered Employee with respect to such
Award, and the Committee wishes such Award to qualify for the Section
162(m) Exemption. If an Award is so designated, the Committee shall
establish performance goals for such Award within the time period
prescribed by Section 162(m) of the Code based on one or more of the
following Qualified Business Criteria, which may be expressed in terms of
Company-wide objectives

C-12

or in terms of objectives that relate to the performance of an Affiliate or
a division, region, department or function within the Company or an
Affiliate:

- Revenue

- Sales

- Profit (net profit, gross profit, operating profit, economic

profit, profit margins or other corporate profit measures)

- Earnings (EBIT, EBITDA, earnings per share, or other corporate

earnings measures)

- Net income (before or after taxes, operating income

or other income measures)

- Cash (cash flow, cash generation, working capital,

or other cash measures)

- Stock price or performance

- Total stockholder return (stock price appreciation

plus reinvested dividends)

- Return on equity

- Return on assets

- Return on investment

- Market share

- Improvements in capital structure

- Expenses (expense management, expense ratio, expense efficiency

ratios or other expense measures)

- Business expansion or consolidation (acquisitions, divestitures,

in-licensing, or product acquisitions)

- Market capitalization

- Clinical and regulatory milestones

- Corporate financing activities

- Supply, production, and manufacturing milestones

- Corporate partnerships or strategic alliances

(c) Each Qualified Performance-Based Award (other than a market-priced
Option or SAR) shall be earned, vested and payable (as applicable) only
upon the achievement of performance goals established by the Committee
based upon one or more of the Qualified Business Criteria, together with
the satisfaction of any other conditions, such as continued employment, as
the Committee may determine to be appropriate; provided, however, that the
Committee may provide, either in connection with the grant thereof or by
amendment thereafter, that achievement of such performance goals will be
waived upon the death or Disability of the Participant or upon a Change in
Control.

(d) Any payment of a Qualified Performance-Based Award granted with
performance goals pursuant to subsection (c) above shall be conditioned on
the written certification of the Committee in each case that the
performance goals and any other material conditions were satisfied. Except
as specifically provided in subsection (c), no Qualified Performance-Based
Award may be amended, nor may the Committee exercise any discretionary
authority it may otherwise have under the Plan with respect to a Qualified
Performance-Based Award under the Plan, in any manner to waive the

C-13

achievement of the applicable performance goal based on Qualified Business
Criteria or to increase the amount payable pursuant thereto or the value
thereof, or otherwise in a manner that would cause the Qualified
Performance-Based Award to cease to qualify for the Section 162(m)
Exemption.

(e) Section 5.4 sets forth the maximum number of Shares or dollar
value that may be granted in any one-year period to a Participant in
designated forms of Qualified Performance-Based Awards.

13.11. TERMINATION OF EMPLOYMENT. Whether military, government or other
service or other leave of absence shall constitute a termination of employment
shall be determined in each case by the Committee at its discretion, and any
determination by the Committee shall be final and conclusive. A Participant's
Continuous Status as a Participant shall not be deemed to terminate (i) in a
circumstance in which a Participant transfers from the Company to an Affiliate,
transfers from an Affiliate to the Company, or transfers from one Affiliate to
another Affiliate, or (ii) in the discretion of the Committee as specified at or
prior to such occurrence, in the case of a spin-off, sale or disposition of the
Participant's employer from the Company or any Affiliate. To the extent that
this provision causes Incentive Stock Options to extend beyond three months from
the date a Participant is deemed to be an employee of the Company, a Parent or
Subsidiary for purposes of Sections 424(e) and 424(f) of the Code, the Options
held by such Participant shall be deemed to be Nonstatutory Stock Options.

ARTICLE 14

CHANGES IN CAPITAL STRUCTURE

14.1. GENERAL. In the event of a corporate event or transaction involving
the Company (including, without limitation, any stock dividend, stock split,
extraordinary cash dividend, recapitalization, reorganization, merger,
consolidation, split-up, spin-off, combination or exchange of shares), the
authorization limits under Section 5.1 and 5.4 shall be adjusted
proportionately, and the Committee may adjust Awards to preserve the benefits or
potential benefits of the Awards. Action by the Committee may include: (i)
adjustment of the number and kind of shares which may be delivered under the
Plan; (ii) adjustment of the number and kind of shares subject to outstanding
Awards; (iii) adjustment of the exercise price of outstanding Awards or the
measure to be used to determine the amount of the benefit payable on an Award;
and (iv) any other adjustments that the Committee determines to be equitable. In
addition, the Committee may, in its sole discretion, provide (i) that Awards
will be settled in cash rather than Stock, (ii) that Awards will become
immediately vested and exercisable and will expire after a designated period of
time to the extent not then exercised, (iii) that Awards will be assumed by
another party to a transaction or otherwise be equitably converted or
substituted in connection with such transaction, (iv) that outstanding Awards
may be settled by payment in cash or cash equivalents equal to the excess of the
Fair Market Value of the underlying Stock, as of a specified date associated
with the transaction, over the exercise price of the Award, or (v) any
combination of the foregoing. The Committee's determination need not be uniform
and may be different for different Participants whether or not such Participants
are similarly situated. Without limiting the foregoing, in the event of a
subdivision of the outstanding Stock (stock-split), a declaration of a dividend
payable in Shares, or a combination or consolidation of the outstanding Stock
into a lesser number of Shares, the authorization limits under Section 5.1 and
5.4 shall automatically be adjusted proportionately, and the Shares then subject
to each Award shall automatically be adjusted proportionately without any change
in the aggregate purchase price therefor.

ARTICLE 15

AMENDMENT, MODIFICATION AND TERMINATION

15.1. AMENDMENT, MODIFICATION AND TERMINATION. The Board or the Committee
may, at any time and from time to time, amend, modify or terminate the Plan
without shareholder approval; provided, however, that if an amendment to the
Plan would, in the reasonable opinion of the Board or the Committee, either (i)
materially increase the benefits accruing to Participants, (ii) materially
increase the number of Shares available under the Plan, (iii) expand the types
of awards under the Plan, (iv) materially expand the class of participants
eligible to participate in the Plan, (v) materially extend the term of the Plan,

C-14

or (vi) otherwise constitute a material change requiring shareholder approval
under applicable laws, policies or regulations or the applicable listing or
other requirements of an Exchange, then such amendment shall be subject to
shareholder approval; and provided, further, that the Board or Committee may
condition any other amendment or modification on the approval of shareholders of
the Company for any reason, including by reason of such approval being necessary
or deemed advisable to (i) permit Awards made hereunder to be exempt from
liability under Section 16(b) of the 1934 Act, (ii) to comply with the listing
or other requirements of an Exchange, or (iii) to satisfy any other tax,
securities or other applicable laws, policies or regulations.

15.2. AWARDS PREVIOUSLY GRANTED. At any time and from time to time, the
Committee may amend, modify or terminate any outstanding Award without approval
of the Participant; provided, however:

(a) Subject to the terms of the applicable Award Certificate, such
amendment, modification or termination shall not, without the Participant's
consent, reduce or diminish the value of such Award determined as if the
Award had been exercised, vested, cashed in or otherwise settled on the
date of such amendment or termination (with the per-share value of an
Option or Stock Appreciation Right for this purpose being calculated as the
excess, if any, of the Fair Market Value as of the date of such amendment
or termination over the exercise or base price of such Award);

(b) The original term of an Option may not be extended without the
prior approval of the shareholders of the Company;

(c) Except as otherwise provided in Article 14, the exercise price of
an Option may not be reduced, directly or indirectly, without the prior
approval of the shareholders of the Company; and

(d) No termination, amendment, or modification of the Plan shall
adversely affect any Award previously granted under the Plan, without the
written consent of the Participant affected thereby. An outstanding Award
shall not be deemed to be "adversely affected" by a Plan amendment if such
amendment would not reduce or diminish the value of such Award determined
as if the Award had been exercised, vested, cashed in or otherwise settled
on the date of such amendment (with the per-share value of an Option or
Stock Appreciation Right for this purpose being calculated as the excess,
if any, of the Fair Market Value as of the date of such amendment over the
exercise or base price of such Award).

ARTICLE 16

GENERAL PROVISIONS

16.1. NO RIGHTS TO AWARDS; NON-UNIFORM DETERMINATIONS. No Participant or
any Eligible Participant shall have any claim to be granted any Award under the
Plan. Neither the Company, its Affiliates nor the Committee is obligated to
treat Participants or Eligible Participants uniformly, and determinations made
under the Plan may be made by the Committee selectively among Eligible
Participants who receive, or are eligible to receive, Awards (whether or not
such Eligible Participants are similarly situated).

16.2. NO SHAREHOLDER RIGHTS. No Award gives a Participant any of the
rights of a shareholder of the Company unless and until Shares are in fact
issued to such person in connection with such Award.

16.3. WITHHOLDING. The Company or any Affiliate shall have the authority
and the right to deduct or withhold, or require a Participant to remit to the
Company, an amount sufficient to satisfy federal, state, and local taxes
(including the Participant's FICA obligation) required by law to be withheld
with respect to any exercise, lapse of restriction or other taxable event
arising as a result of the Plan. If Shares are surrendered to the Company to
satisfy withholding obligations in excess of the minimum withholding obligation,
such Shares must have been held by the Participant as fully vested shares for
such period of time, if any, as necessary to avoid variable accounting for the
Option. With respect to withholding required upon any taxable event under the
Plan, the Committee may, at the time the Award is granted or thereafter, require
or

C-15

permit that any such withholding requirement be satisfied, in whole or in part,
by withholding from the Award Shares having a Fair Market Value on the date of
withholding equal to the minimum amount (and not any greater amount) required to
be withheld for tax purposes, all in accordance with such procedures as the
Committee establishes.

16.4. NO RIGHT TO CONTINUED SERVICE. Nothing in the Plan, any Award
Certificate or any other document or statement made with respect to the Plan,
shall interfere with or limit in any way the right of the Company or any
Affiliate to terminate any Participant's employment or status as an officer,
director or consultant at any time, nor confer upon any Participant any right to
continue as an employee, officer, director or consultant of the Company or any
Affiliate, whether for the duration of a Participant's Award or otherwise.

16.5. UNFUNDED STATUS OF AWARDS. The Plan is intended to be an "unfunded"
plan for incentive and deferred compensation. With respect to any payments not
yet made to a Participant pursuant to an Award, nothing contained in the Plan or
any Award Certificate shall give the Participant any rights that are greater
than those of a general creditor of the Company or any Affiliate.

16.6. RELATIONSHIP TO OTHER BENEFITS. No payment under the Plan shall be
taken into account in determining any benefits under any pension, retirement,
savings, profit sharing, group insurance, welfare or benefit plan of the Company
or any Affiliate unless provided otherwise in such other plan.

16.7. EXPENSES. The expenses of administering the Plan shall be borne by
the Company and its Affiliates.

16.8. TITLES AND HEADINGS. The titles and headings of the Sections in the
Plan are for convenience of reference only, and in the event of any conflict,
the text of the Plan, rather than such titles or headings, shall control.

16.9. GENDER AND NUMBER. Except where otherwise indicated by the context,
any masculine term used herein also shall include the feminine; the plural shall
include the singular and the singular shall include the plural.

16.10. FRACTIONAL SHARES. No fractional Shares shall be issued and the
Committee shall determine, in its discretion, whether cash shall be given in
lieu of fractional Shares or whether such fractional Shares shall be eliminated
by rounding up or down.

16.11. GOVERNMENT AND OTHER REGULATIONS.

(a) Notwithstanding any other provision of the Plan, no Participant
who acquires Shares pursuant to the Plan may, during any period of time
that such Participant is an affiliate of the Company (within the meaning of
the rules and regulations of the Securities and Exchange Commission under
the 1933 Act), sell such Shares, unless such offer and sale is made (i)
pursuant to an effective registration statement under the 1933 Act, which
is current and includes the Shares to be sold, or (ii) pursuant to an
appropriate exemption from the registration requirement of the 1933 Act,
such as that set forth in Rule 144 promulgated under the 1933 Act.

(b) Notwithstanding any other provision of the Plan, if at any time
the Committee shall determine that the registration, listing or
qualification of the Shares covered by an Award upon any Exchange or under
any foreign, federal, state or local law or practice, or the consent or
approval of any governmental regulatory body, is necessary or desirable as
a condition of, or in connection with, the granting of such Award or the
purchase or receipt of Shares thereunder, no Shares may be purchased,
delivered or received pursuant to such Award unless and until such
registration, listing, qualification, consent or approval shall have been
effected or obtained free of any condition not acceptable to the Committee.
Any Participant receiving or purchasing Shares pursuant to an Award shall
make such representations and agreements and furnish such information as
the Committee may request to assure compliance with the foregoing or any
other applicable legal requirements. The Company shall not be required to
issue or deliver any certificate or certificates for Shares under the Plan
prior to the Committee's determination that all related requirements have
been fulfilled. The Company shall in no event be obligated to register any
securities pursuant to the 1933 Act or applicable state or foreign law or
to take any other action in

C-16

order to cause the issuance and delivery of such certificates to comply
with any such law, regulation or requirement.

16.12. GOVERNING LAW. To the extent not governed by federal law, the Plan
and all Award Certificates shall be construed in accordance with and governed by
the laws of the State of Delaware.

16.13. ADDITIONAL PROVISIONS. Each Award Certificate may contain such
other terms and conditions as the Committee may determine; provided that such
other terms and conditions are not inconsistent with the provisions of the Plan.

16.14. NO LIMITATIONS ON RIGHTS OF COMPANY. The grant of any Award shall
not in any way affect the right or power of the Company to make adjustments,
reclassification or changes in its capital or business structure or to merge,
consolidate, dissolve, liquidate, sell or transfer all or any part of its
business or assets. The Plan shall not restrict the authority of the Company,
for proper corporate purposes, to draft or assume awards, other than under the
Plan, to or with respect to any person. If the Committee so directs, the Company
may issue or transfer Shares to an Affiliate, for such lawful consideration as
the Committee may specify, upon the condition or understanding that the
Affiliate will transfer such Shares to a Participant in accordance with the
terms of an Award granted to such Participant and specified by the Committee
pursuant to the provisions of the Plan.

The foregoing is hereby acknowledged as being the Keryx Biopharmaceuticals,
Inc. 2004 Long-Term Incentive Plan as adopted by the Board on April 14, 2004 and
by the shareholders on , 2004.

KERYX BIOPHARMACEUTICALS, INC.

By:

------------------------------------

Its:

------------------------------------

C-17

PROXY CARD

KERYX BIOPHARMACEUTICALS, INC.

PROXY FOR THE 2004 ANNUAL MEETING OF STOCKHOLDERS - JUNE 10,2004
(THIS PROXY IS SOLICITED BY OUR BOARD OF DIRECTORS)

The undersigned stockholder of Keryx Biopharmaceuticals, Inc. hereby
appoints Michael S. Weiss, Chief Executive Officer of Keryx Biopharmaceuticals,
Inc., and Ron Bentsur, Secretary of Keryx Biopharmaceuticals, Inc., with full
power of substitution, as proxies to vote the shares of our common stock that
the undersigned could vote if personally present at the Annual Meeting of
Stockholders of Keryx Biopharmaceuticals, Inc. to be held at the offices of the
Company's legal counsel, Alston & Bird LLP, located at 90 Park Avenue, New York,
New York 10016, on June 10, 2004, at 10:00 a.m., local time, or any adjournment
thereof.

(CONTINUED AND TO BE SIGNED ON REVERSE SIDE)

ANNUAL MEETING OF STOCKHOLDERS OF

KERYX BIOPHARMACEUTICALS, INC.

JUNE 10,2004

Please date, sign and mail
your proxy card in the
envelope provided as soon
as possible.

- Please detach along perforated line and mail in the envelope provided.-

PLEASE SIGN, DATE AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE. PLEASE MARK YOUR
VOTE IN BLUE OR BLACK INK AS SHOWN HERE [X]

1. ELECTION OF DIRECTORS:

[ ] FOR ALL NOMINEES

[ ] WITHHOLD AUTHORITY
FOR ALL NOMINEES

[ ] FOR ALL EXCEPT
(See instructions below)

NOMINEES:

( ) Michael S. Weiss

( ) I. Craig Henderson, M.D.

( ) Malcolm Hoenlein

( ) Peter M. Kash

( ) Lawrence Jay Kessel, M.D.

( ) Lindsay A. Rosenwald, M.D.

( ) Peter Salomon, M.D.

INSTRUCTIONS: To withhold authority to vote for any individual nominee(s)
mark "FOR ALL EXCEPT" and fill in the circle next to each
nominee you wish to withhold, as shown here: (x)

To change the address on your account, please check the box [ ]
at right and indicate your new address in the address space
above. Please note that changes to the registered name(s) on
the account may not be submitted via this method.

Signature of Stockholder Date:
------------------------------------ ----------

FOR AGAINST ABSTAIN

2. Subject to the achievement of certain [ ] [ ] [ ]
milestones, the issuance of up to
3,372,422 shares of our common stock to the
former stockholders of ACCESS Oncology, Inc.
(in lieu of cash having an equivalent value
that will otherwise be deliverable).

3. Approval of our 2004 Long-Term Incentive [ ] [ ] [ ]
Plan.

4. Approval of the delisting of our common [ ] [ ] [ ]
stock from the Alternative Investment
Market of the London Stock Exchange.

5. Approval of the amendment of our certificate [ ] [ ] [ ]
of incorporation to increase the number
of authorized shares of our common stock.

UNLESS OTHERWISE SPECIFIED, THIS PROXY WILL BE VOTED "FOR" THE ELECTION OF
DIRECTORS NAMED IN NUMBER 1 ABOVE, "FOR" THE ISSUANCE OF SHARES OF OUR COMMON
STOCK IN CONNECTION WITH THE ACQUISITION OF ACCESS ONCOLOGY, "FOR" THE APPROVAL
OF OUR 2004 LONG-TERM INCENTIVE PLAN, "FOR" THE DELISTING OF OUR COMMON STOCK
FROM THE ALTERNATIVE INVESTMENT MARKET, AND "FOR" THE AMENDMENT OF OUR
CERTIFICATE OF INCORPORATION TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF OUR
COMMON STOCK.

Signature of Stockholder Date:
------------------------------------ ----------

NOTE: PLEASE SIGN EXACTLY AS YOUR NAME OR NAMES APPEAR ON THIS PROXY. WHEN
SHARES ARE HELD JOINTLY, EACH HOLDER SHOULD SIGN. WHEN SIGNING AS
EXECUTOR, ADMINISTRATOR, ATTORNEY, TRUSTEE OR GUARDIAN, PLEASE GIVE FULL
TITLE AS SUCH. IF THE SIGNER IS A CORPORATION, PLEASE SIGN FULL CORPORATE
NAME BY DULY AUTHORIZED OFFICER, GIVING FULL TITLE AS SUCH. IF SIGNER IS A
PARTNERSHIP, PLEASE SIGN IN PARTNERSHIP NAME BY AUTHORIZED PERSON.