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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                   UNDER THE SECURITIES EXCHANGE ACT OF 1934

                              (AMENDMENT NO. ___)*



                                  ABIOMED, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    003654100
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                 MARCH 15, 2007
--------------------------------------------------------------------------------
            (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]  Rule 13d-1(b)

[X]  Rule 13d-1(c)

[ ]  Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



PERSONS WHO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS FORM ARE
NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB CONTROL
NUMBER.




------------------------                                     ------------------
CUSIP NO.  76028H100                    13G                  Page 2 of 8 Pages
------------------------                                     ------------------


  1.    NAMES OF REPORTING PERSONS

        Great Point Partners, LLC

        I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

        37-1475292

  2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (a)   [ ]

        (b)   [ ]

--------------------------------------------------------------------------------
  3.    SEC USE ONLY


--------------------------------------------------------------------------------
  4.    CITIZENSHIP OR PLACE OF ORGANIZATION

        USA

                     5.  SOLE VOTING POWER
NUMBER OF SHARES

  BENEFICIALLY       6.  SHARED VOTING POWER

 OWNED BY EACH                                  1,600,000

REPORTING PERSON     7.  SOLE DISPOSITIVE POWER

      WITH           8.  SHARED DISPOSITIVE POWER

                                                1,600,000

   9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              1,600,000

  10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        (See Instructions)                                               [ ]


  11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

              5.98%

  12. TYPE OF REPORTING PERSON (See Instructions)

              OO




------------------------                                     ------------------
CUSIP NO.  76028H100                    13G                  Page 3 of 8 Pages
------------------------                                     ------------------


  1.    NAMES OF REPORTING PERSONS

        Dr. Jeffrey R. Jay, M.D.

        I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):


  2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (a)   [ ]

        (b)   [ ]


--------------------------------------------------------------------------------
  3.    SEC USE ONLY



--------------------------------------------------------------------------------
  4.    CITIZENSHIP OR PLACE OF ORGANIZATION

        USA

                     5.  SOLE VOTING POWER
NUMBER OF SHARES
                                                0
  BENEFICIALLY
                     6.  SHARED VOTING POWER
 OWNED BY EACH
                                                1,600,000
REPORTING PERSON     7.  SOLE DISPOSITIVE POWER

      WITH                                      0

                     8.  SHARED DISPOSITIVE POWER

                                                1,600,000

   9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              1,600,000

  10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        (See Instructions)                                               [ ]


  11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

              5.98%

  12. TYPE OF REPORTING PERSON (See Instructions)

              IN




------------------------                                     ------------------
CUSIP NO.  76028H100                    13G                  Page 4 of 8 Pages
------------------------                                     ------------------


  ITEM 1.

             (a)    Name of Issuer

                    ABIOMED, Inc.

             (b)    Address of Issuer's Principal Executive Offices

                    22 Cherry Hill Drive
                    Danvers, MA 01923


  ITEM 2.

             (a)   Name of Person Filing

                         Great Point Partners, LLC
                         Dr. Jeffrey R. Jay, M.D.

             The Reporting Persons have entered into a Joint Filing Agreement,
             dated March 22, 2007, a copy of which is filed with this Schedule
             13G as Exhibit A, pursuant to which the Reporting Persons have
             agreed to file this statement jointly in accordance with the
             provisions of Rule 13d-1(k)(1) under the Act.


             (b)   Address of Principal Business Office, or if none, Residence

                   The address of the principal business office of each of the
                   Reporting Persons is

                         165 Mason Street, 3rd Floor
                         Greenwich, CT 06830

             (c)   Citizenship

             Great Point Partners, LLC is a limited liability company organized
             under the laws of the State of Delaware.  Dr. Jeffrey R. Jay, M.D.
             is a citizen of the United States.

             (d)   Title of Class of Securities

                   Common Stock

             (e)   CUSIP Number

                   003654100

  ITEM 3.    IF THIS STATEMENT IS FILED PURSUANT TO ss.240.13D-1(b) OR
             240.13d.2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

                   Not Applicable.

             (a) [ ] Broker or dealer registered under Section 15 of the Act (15
                     U.S.C. 78o)

             (b) [ ] Bank as defined in Section 3(a)(6) of the Act (15 U.S.C.
                     78c).

             (c) [ ] Insurance company as defined in Section 3(a)(19) of the Act
                     (15. U.S.C. 78c).

             (d) [ ] Investment Company registered under Section 8 of the
                     Investment Company Act of 1940 (15 U.S.C. 80a-8).



------------------------                                     ------------------
CUSIP NO.  76028H100                    13G                  Page 5 of 8 Pages
------------------------                                     ------------------


             (e) [ ] An investment adviser in accordance with
                     ss.240.13d-1(b)(1)(ii)(E).

             (f) [ ] An employee benefit plan or endowment fund in accordance
                     with ss.240.13d-1(b)(1)(ii)(F).

             (g) [ ] A parent holding company or control person in accordance
                     with ss.240.13d-1(b)(1)(ii)(G).

             (h) [ ] A savings associations as defined in Section 3(b) of the
                     Federal Deposit Insurance Act (12 U.S.C. 1813).

             (i) [ ] A church plan that is excluded from the definition of an
                     investment company under Section 3(c)(14) of the Investment
                     Company Act of 1940 (15 U.S.C. 80a-3).

             (j) [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

  ITEM 4.    OWNERSHIP

             Great Point Partners, LLC ("Great Point") is the investment manager
             of Biomedical Value Fund, L.P. ("BVF"), and by virtue of such
             status may be deemed to be the beneficial owner of the 864,000
             shares of Common Stock of the Issuer owned by BVF (the "BVF
             Shares"). Dr. Jeffrey R. Jay, M.D. ("Dr. Jay"), as senior managing
             member of Great Point, has voting and investment power with respect
             to the BVF Shares, and therefore may be deemed to be the beneficial
             owner of the BVF Shares.

             Great Point is the investment manager of Biomedical Offshore Value
             Fund, Ltd. ("BOVF"), and by virtue of such status may be deemed to
             be the beneficial owner of the 736,000 shares of Common Stock of
             the Issuer owned by BOVF (the "BOVF Shares"). Dr. Jay, as senior
             managing member of Great Point, has voting and investment power
             with respect to the BOVF Shares, and therefore may be deemed to be
             the beneficial owner of the BOVF Shares.

             Great Point and Dr. Jay disclaim beneficial ownership of the BVF
             Shares and the BOVF Shares, except to the extent of their
             respective pecuniary interest.


             Provide the following information regarding the aggregate number
             and percentage of the class of securities of the issuer identified
             in Item 1.

             1.    GREAT POINT PARTNERS, LLC

             (a)   Amount beneficially owned: 1,600,000

             (b)   Percent of class: 5.98%.

             (c)   Number of shares as to which the person has:

                   (i)   Sole power to vote or to direct the vote:  - 0 -

                   (ii)  Shared power to vote or to direct the vote: 1,600,000

                   (iii) Sole power to dispose or to direct the disposition of:
                         - 0 -.

                   (iv)  Shared power to dispose or to direct the disposition
                         of: 1,600,000

             2.    DR. JEFFREY R. JAY, M.D.

             (a)   Amount beneficially owned: 1,600,000

             (b)   Percent of class: 5.98%.



------------------------                                     ------------------
CUSIP NO.  76028H100                    13G                  Page 6 of 8 Pages
------------------------                                     ------------------


             (c)   Number of shares as to which the person has:

                   (i)   Sole power to vote or to direct the vote: 0.

                   (ii)  Shared power to vote or to direct the vote: 1,600,000

                   (iii) Sole power to dispose or to direct the disposition of:
                         0.

                   (iv)  Shared power to dispose or to direct the disposition
                         of: 1,600,000


ITEM 5.     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

            If this statement is being filed to report the fact that as of the
date hereof each of the Reporting Persons has ceased to be the beneficial owner
of more than five percent of the class of securities, check the following [ ].

ITEM 6.     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

            See item 4.

ITEM 7.     IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
            ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
            COMPANY

            Not Applicable.

ITEM 8.     IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

            Not Applicable.

ITEM 9.     NOTICE OF DISSOLUTION OF GROUP

            Not Applicable.

ITEM 10.    CERTIFICATION

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as
participant in any transaction having that purpose or effect.





------------------------                                     ------------------
CUSIP NO.  76028H100                    13G                  Page 7 of 8 Pages
------------------------                                     ------------------



                                    SIGNATURE
                                    ---------

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date:  March 22, 2007

                                    GREAT POINT PARTNERS, LLC

                                    By:   /s/ Dr. Jeffrey R. Jay, M.D.
                                          ------------------------------------
                                          Dr. Jeffrey R. Jay, M.D.,
                                           as senior managing member

                                    /s/ Dr. Jeffrey R. Jay, M.D.
                                    ------------------------------------------
                                    DR. JEFFREY R. JAY, M.D.




                                                                       Exhibit A
                                                                       ---------


             AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G


The undersigned hereby agree as follows:

      (i)   Each of them is individually eligible to use the Schedule 13G to
which this Exhibit is attached, and such Schedule 13G is filed on behalf of each
of them; and

      (ii)  Each of them is responsible for the timely filing of such Schedule
13G and any amendments thereto, and for the completeness and accuracy of the
information concerning such person contained therein; but none of them is
responsible for the completeness or accuracy of the information concerning the
other persons making the filing, unless such person knows or has reason to
believe that such information is inaccurate.

Date:  March 22, 2007

                                    GREAT POINT PARTNERS, LLC

                                    By: /s/ Dr. Jeffrey R. Jay, M.D.
                                        ----------------------------------------
                                        Dr. Jeffrey R. Jay, M.D.,
                                          as senior managing member


                                    /s/ Dr. Jeffrey R. Jay, M.D.
                                    --------------------------------------------
                                    DR. JEFFREY R. JAY, M.D.