Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
SHARER KEVIN W
  2. Issuer Name and Ticker or Trading Symbol
AMGEN INC [AMGN]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman of the Bd, CEO & Pres
(Last)
(First)
(Middle)
ONE AMGEN CENTER DRIVE
3. Date of Earliest Transaction (Month/Day/Year)
04/29/2005
(Street)

THOUSAND OAKS, CA 91320-1799
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 04/29/2005   M   3,052 A $ 16.375 3,052 D  
Common Stock 04/29/2005   M   1,642 A $ 30.4375 4,694 D  
Common Stock 04/29/2005   M   2,608 A $ 38.36 7,302 D  
Common Stock 04/29/2005   M   22,358 A $ 30.4375 29,660 D  
Common Stock 04/29/2005   M   4,000 A $ 38.36 33,660 D  
Common Stock 04/29/2005   G V 33,660 (1) D $ 0 0 D  
Common Stock 04/29/2005   G V 33,660 (1) A $ 0 66,751 (2) I Living Trust
Common Stock 04/29/2005   I   3,224.201 A $ 0 3,224.201 (3) I By 401(k) Plan

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
ISO (Right to Buy) $ 16.375 04/29/2005   M     3,052 07/01/2003 07/01/2005 Common Stock 3,052 $ 0 0 D  
ISO (Right to Buy) $ 30.4375 04/29/2005   M     1,642 07/01/2004 07/01/2006 Common Stock 1,642 $ 0 0 D  
ISO (Right to Buy) $ 38.36 04/29/2005   M     2,608 07/01/2003 07/01/2009 Common Stock 2,608 $ 0 1 D  
NQSO (Right to Buy) $ 30.4375 04/29/2005   M     22,358 07/01/2001 07/01/2006 Common Stock 22,358 $ 0 0 D  
NQSO (Right to Buy) $ 38.36 04/29/2005   M     4,000 07/01/2003 07/01/2009 Common Stock 4,000 $ 0 375,159 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
SHARER KEVIN W
ONE AMGEN CENTER DRIVE
THOUSAND OAKS, CA 91320-1799
  X     Chairman of the Bd, CEO & Pres  

Signatures

 /s/ N. Cris Prince, By Power of Attorney   05/02/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) (KWS 4.29.05) Transfer of shares into reporting person's living trust.
(2) (KWS 2.14.05) The amount of the Company's Common Stock beneficially owned has been adjusted to reflect an acquisition by the reporting person of the Company's Common Stock under the 423(b) Plan in a transaction exempt pursuant to Rule 16a-3(f)(1)(k)(B) and subsequent transfer of such shares to reporting person's living trust.
(3) (KWS 401(k)) These are units acquired under the Company's 401(k) Plan and represent interests in the Company's stock fund.

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