UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D
Under the Securities Exchange Act of 1934

(Amendment No. 37)

 

Genomic Health, Inc.
(Name of Issuer)
Common Stock, par value $0.0001 per share
(Title of Class of Securities)
	37244C101
	(CUSIP Number)
Alexandra A. Toohey Chief Financial Officer Baker Bros. Advisors LP 860 Washington Street, 3rd Floor New York, NY 10014 (212) 339-5690 (Name, address and telephone number of person authorized to receive notices and communications)
	January 17, 2019
	(Date of Event which Requires Filing of this Statement)

 

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box. ¨

 

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

 

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

 

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (the “Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

CUSIP No.   37244C101

Page   2   of   14   Pages

 

1	NAMES OF REPORTING PERSONS   Baker Bros. Advisors LP
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)			(a) ¨   (b) ¨
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions)   OO
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
6	CITIZENSHIP OR PLACE OF ORGANIZATION   Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER   11,430,796 (1)
		8	SHARED VOTING POWER   0
		9	SOLE DISPOSITIVE POWER   11,430,796 (1)
		10	SHARED DISPOSITIVE POWER   0
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   11,430,796 (1)
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)				¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)   31.5% (1)(2)
14	TYPE OF REPORTING PERSON (See Instructions)   IA, PN

(1)

Includes 82,765 shares of the common stock of Genomic Health, Inc. (the “Issuer”) underlying options directly held by Julian C. Baker, 66,265 shares of the Issuer’s common stock underlying options directly held by Felix J. Baker, 32,412 shares of the Issuer’s common stock directly held by Julian C. Baker and 8,317 shares of the Issuer’s common stock directly held by Felix J. Baker.

(2)

Based on 36,123,297 shares of the Issuer’s common stock outstanding as of October 31, 2018, as reported in the Issuer’s Form 10-Q filed with the Securities and Exchange Commission (“SEC”) on November 8, 2018.

 

 

CUSIP No.   37244C101

Page   3   of   14   Pages

 

1	NAMES OF REPORTING PERSONS   Baker Bros. Advisors (GP) LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)			(a) ¨   (b) ¨
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions)   OO
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
6	CITIZENSHIP OR PLACE OF ORGANIZATION   Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER   11,430,796 (1)
		8	SHARED VOTING POWER   0
		9	SOLE DISPOSITIVE POWER   11,430,796 (1)
		10	SHARED DISPOSITIVE POWER   0
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   11,430,796 (1)
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)				¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)   31.5% (1)(2)
14	TYPE OF REPORTING PERSON (See Instructions)   HC, OO

(1)

Includes 82,765 shares of the common stock of the Issuer underlying options directly held by Julian C. Baker, 66,265 shares of the Issuer’s common stock underlying options directly held by Felix J. Baker, 32,412 shares of the Issuer’s common stock directly held by Julian C. Baker and 8,317 shares of the Issuer’s common stock directly held by Felix J. Baker.

(2)

Based on 36,123,297 shares of the Issuer’s common stock outstanding as of October 31, 2018, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2018.

 

 

CUSIP No.   37244C101

Page   4   of   14  Pages

 

1	NAMES OF REPORTING PERSONS   Julian C. Baker
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)			(a) ¨   (b) ¨
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions)   OO
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
6	CITIZENSHIP OR PLACE OF ORGANIZATION   United States
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER   11,604,693 (1)
		8	SHARED VOTING POWER   0
		9	SOLE DISPOSITIVE POWER   11,604,693 (1)
		10	SHARED DISPOSITIVE POWER   0
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   11,604,693 (1)
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)				¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)   32.0% (1)(2)
14	TYPE OF REPORTING PERSON (See Instructions)   IN, HC

(1)

Includes 82,765 shares of the common stock of the Issuer underlying options directly held by Julian C. Baker, 66,265 shares of the Issuer’s common stock underlying options directly held by Felix J. Baker, 32,412 shares of the Issuer’s common stock directly held by Julian C. Baker and 8,317 shares of the Issuer’s common stock directly held by Felix J. Baker.

(2)

Based on 36,123,297 shares of the Issuer’s common stock outstanding as of October 31, 2018, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2018.

 

 

CUSIP No.  37244C101

Page   5   of   14    Pages

 

1	NAMES OF REPORTING PERSONS   Felix J. Baker
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)			(a) ¨ (b) ¨
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions)   OO
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
6	CITIZENSHIP OR PLACE OF ORGANIZATION   United States
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER   11,604,693 (1)
		8	SHARED VOTING POWER   0
		9	SOLE DISPOSITIVE POWER   11,604,693 (1)
		10	SHARED DISPOSITIVE POWER   0
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   11,604,693 (1)
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)				¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)   32.0% (1)(2)
14	TYPE OF REPORTING PERSON (See Instructions)   IN, HC

(1)

Includes 82,765 shares of the common stock of the Issuer underlying options directly held by Julian C. Baker, 66,265 shares of the Issuer’s common stock underlying options directly held by Felix J. Baker, 32,412 shares of the Issuer’s common stock directly held by Julian C. Baker and 8,317 shares of the Issuer’s common stock directly held by Felix J. Baker.

(2)

Based on 36,123,297 shares of the Issuer’s common stock outstanding as of October 31, 2018, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2018.

 

 

CUSIP No.   37244C101

Page   6   of   14   Pages

 

1	NAMES OF REPORTING PERSONS   FBB Associates
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)			(a) ¨   (b) ¨
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions)   OO
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
6	CITIZENSHIP OR PLACE OF ORGANIZATION   New York
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER   173,897
		8	SHARED VOTING POWER   0
		9	SOLE DISPOSITIVE POWER   173,897
		10	SHARED DISPOSITIVE POWER   0
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   173,897
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)				¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)   0.5% (1)
14	TYPE OF REPORTING PERSON (See Instructions)   OO

(1)

Based on 36,123,297 shares of the Issuer’s common stock outstanding as of October 31, 2018, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2018.

 

 

Amendment No. 37 to Schedule 13D

 

This Amendment No. 37 to Schedule 13D amends and supplements the statements on the previously filed Schedule 13D, as amended, filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP) LLC (the “Adviser GP”), Julian C. Baker, Felix J. Baker, and FBB Associates (“FBB”) collectively, (the “Reporting Persons”). Except as supplemented herein, such statements, as hereto amended and supplemented, remain in full force and effect. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Each capitalized term used but not defined herein has the meaning ascribed to such term in the Schedule 13D, as amended.

 

The Adviser GP is the sole general partner of the Adviser. Pursuant to the management agreements, as amended, among the Adviser, Baker Brothers Life Sciences, L.P. (“Life Sciences”), 14159, L.P. (“14159”), 667, L.P. (“667”), Baker Bros. Investments, L.P. (“Baker Bros. Investments”), Baker Bros. Investments II, L.P. (“Baker Bros. Investments II”), and Baker/Tisch Investments, L.P. (“Baker Tisch”, and together with Life Sciences, 14159, 667, Baker Bros. Investments and Baker Bros. Investments II, the “Funds”), and their respective general partners, the Funds’ respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting power of securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over investments.

 

Item 3.

Source and Amount of Funds or Other Consideration

 

Item 3 of Schedule 13D is supplemented and amended, as the case may be, as follows:

 

The disclosure in Item 4 below is incorporated herein by reference.

 

Item 4.

Purpose of the Transaction.

 

Item 4 of Schedule 13D is supplemented and amended, as the case may be, as follows:

 

This Amendment No. 37 is being filed to report the sale of shares of the common stock of Genomic Health, Inc. (the “Issuer”) reported in Item 5(c) that resulted in a more than 1 percent change in beneficial ownership. The disclosure regarding the sales in Item 5(c) below is incorporated herein by reference.

 

The Funds hold securities of the Issuer for investment purposes. The Reporting Persons or their affiliates may dispose of additional securities of the Issuer or purchase securities in varying amounts and at varying times depending upon the Reporting Persons’ continuing assessments of pertinent factors, including the availability of shares of common stock or other securities for purchase at particular price levels, the business prospects of the Issuer, other business investment opportunities, economic conditions, stock market conditions, money market conditions, the attitudes and actions of the Board and management of the Issuer, the availability and nature of opportunities to dispose of shares of the Issuer and other plans and requirements of the particular entities. The Reporting Persons may discuss items of mutual interest with the Issuer, which could include items in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

 

Depending upon their assessments of the above factors, the Reporting Persons or their affiliates may change their present intentions as stated above and they may make suggestions to the management of the Issuer regarding financing, and may acquire additional securities of the Issuer, including shares of common stock (by means of open market purchases, privately negotiated purchases, exercise of some or all of the Stock Options (as defined below), or otherwise) or may dispose of some or all of the securities of the Issuer, including shares of common stock, under their control.

 

 

Except as otherwise disclosed herein, at the present time, the Reporting Persons do not have any plans or proposals with respect to any extraordinary corporate transaction involving the Issuer including, without limitation, those matters described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

 

Item 5.

Interest in Securities of the Issuer.

 

Item 5 of this Schedule 13D is hereby amended and restated in its entirety as follows:

 

(a) and (b) Items 7 through 11 and 13 of each of the cover pages of this Amendment No. 37 are incorporated herein by reference. Set forth below is the aggregate number of shares of common stock of the Issuer directly held by each of the Funds and the percentage of the Issuer’s outstanding shares of common stock such holdings represent. The information set forth below is based upon 36,123,297 shares of common stock outstanding as of October 31, 2018, as reported in the Issuer’s Form 10-Q filed with the SEC on November 8, 2018. Such percentage figures are calculated in accordance with Rule 13d-3 under the Securities Exchange Act of 1934, as amended.

 

Name		Number of Shares				Percentage of Class Outstanding
Baker Bros. Investments, L.P.			142,156				0.4	%
Baker Bros. Investments II, L.P.			10,821				0.0	%
667, L.P.			1,422,019				3.9	%
Baker Brothers Life Sciences, L.P.			9,262,200				25.6	%
14159, L.P.			245,119				0.7	%
Baker/Tisch Investments, L.P.			158,722				0.4	%

 

The Adviser GP, Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds, and may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of such securities. Julian C. Baker and Felix J. Baker are also the sole partners of FBB, a general partnership, and as such may be deemed to be beneficial owners of shares of common stock directly held by FBB and may be deemed to have the power to vote or direct the vote and dispose or direct the disposition of those shares.

 

The Reporting Persons disclaim beneficial ownership of the securities directly held by each of the Funds, and this Amendment No. 37 shall not be deemed an admission that the Reporting Persons are the beneficial owners of such securities for purposes of Section 13(d) or for any other purpose.

 

Julian C. Baker and Felix J. Baker are Directors of the Issuer. Julian C. Baker serves as the Chair of the Nominating and Corporate Governance Committee and Felix J. Baker serves as the Chair of the Compensation Committee and serves on the Science & Technology Committee of the Issuer’s Board.

 

On January 1, 2019, Felix J. Baker and Julian C. Baker each received 155 shares of restricted stock of the Issuer (“Restricted Stock”) pursuant to the Issuer's 2005 Stock Incentive Plan in lieu of $10,000 in director retainer fees, respectively. The shares of Restricted Stock are fully vested.

 

 

Felix J. Baker and Julian C. Baker serve on the Issuer’s Board as representatives of the Funds. Due to the agreements and policies of the Funds, Felix J. Baker and Julian C. Baker do not have any right to receive any profits from any securities received as compensation for serving as Directors of the Issuer and therefore have no pecuniary interest in the common stock, Restricted Stock received in lieu of director retainer fees or options to purchase common stock of the Issuer (“Stock Options”) received by Felix J. Baker or Julian C. Baker as director compensation. The Funds are entitled to the pecuniary interest in such common stock, Restricted Stock and Stock Options as each holds an indirect pecuniary interest. Felix J. Baker and Julian C. Baker, solely as a result of their ownership interest in the general partners of the general partners of the Funds, may be deemed to have an indirect pecuniary interest in such common stock, Restricted Stock and Stock Options (i.e. no direct pecuniary interest).

 

The Adviser has voting and investment power over the common stock, Restricted Stock and Stock Options held by Julian C. Baker and Felix J. Baker received as director compensation. The Adviser GP, and Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of such common stock, Restricted Stock and Stock Options held by Julian C. Baker and Felix J. Baker received as director compensation.

 

(c) The following transactions in the common stock of the Issuer were effected by the Funds noted below during the fifty days preceding the filing of this statement. The transactions in common stock effected the fifty-first to sixtieth days are disclosed on the previous Schedules 13D filed on December 3, 2018 and November 28, 2018. All transactions were effected in the over-the-counter market directly with a broker-dealer. Except as disclosed herein or in any previous amendments to this Schedule 13D, none of the Reporting Persons or their affiliates has effected any other transactions in securities of the Issuer during the past 60 days.

 

 

Name		Date				Number of Shares				Transaction				Price/Share				Footnotes
Baker/Tisch Investments, L.P.			12/4/2018				6				Sale				77.1100				1
Baker Bros. Investments II, L.P.			12/4/2018				1				Sale				77.1100				1
Baker Bros. Investments, L.P.			12/4/2018				6				Sale				77.1100				1
14159, L.P.			12/4/2018				10				Sale				77.1100				1
667, L.P.			12/4/2018				57				Sale				77.1100				1
Baker Brothers Life Sciences, L.P.			12/4/2018				371				Sale				77.1100				1
Baker/Tisch Investments, L.P.			12/4/2018				319				Sale				75.8309				2
Baker Bros. Investments II, L.P.			12/4/2018				21				Sale				75.8309				2
Baker Bros. Investments, L.P.			12/4/2018				286				Sale				75.8309				2
14159, L.P.			12/4/2018				492				Sale				75.8309				2
667, L.P.			12/4/2018				2,856				Sale				75.8309				2
Baker Brothers Life Sciences, L.P.			12/4/2018				18,604				Sale				75.8309				2
Baker/Tisch Investments, L.P.			12/4/2018				95				Sale				73.8119				3
Baker Bros. Investments II, L.P.			12/4/2018				6				Sale				73.8119				3
Baker Bros. Investments, L.P.			12/4/2018				84				Sale				73.8119				3
14159, L.P.			12/4/2018				146				Sale				73.8119				3
667, L.P.			12/4/2018				843				Sale				73.8119				3
Baker Brothers Life Sciences, L.P.			12/4/2018				5,493				Sale				73.8119				3
Baker/Tisch Investments, L.P.			12/4/2018				43				Sale				77.7455				4
Baker Bros. Investments II, L.P.			12/4/2018				3				Sale				77.7455				4
Baker Bros. Investments, L.P.			12/4/2018				39				Sale				77.7455				4
14159, L.P.			12/4/2018				67				Sale				77.7455				4
667, L.P.			12/4/2018				390				Sale				77.7455				4
Baker Brothers Life Sciences, L.P.			12/4/2018				2,538				Sale				77.7455				4
Baker/Tisch Investments, L.P.			12/6/2018				1,309				Sale				75.4607				5
Baker Bros. Investments II, L.P.			12/6/2018				89				Sale				75.4607				5
Baker Bros. Investments, L.P.			12/6/2018				1,172				Sale				75.4607				5
14159, L.P.			12/6/2018				2,021				Sale				75.4607				5
667, L.P.			12/6/2018				11,724				Sale				75.4607				5
Baker Brothers Life Sciences, L.P.			12/6/2018				76,364				Sale				75.4607				5
Baker/Tisch Investments, L.P.			12/7/2018				1,447				Sale				76.1540				6
Baker Bros. Investments II, L.P.			12/7/2018				99				Sale				76.1540				6
Baker Bros. Investments, L.P.			12/7/2018				1,296				Sale				76.1540				6
14159, L.P.			12/7/2018				2,234				Sale				76.1540				6
667, L.P.			12/7/2018				12,961				Sale				76.1540				6
Baker Brothers Life Sciences, L.P.			12/7/2018				84,418				Sale				76.1540				6
Baker/Tisch Investments, L.P.			12/10/2018				132				Sale				73.8291				7
Baker Bros. Investments II, L.P.			12/10/2018				9				Sale				73.8291				7
Baker Bros. Investments, L.P.			12/10/2018				118				Sale				73.8291				7
14159, L.P.			12/10/2018				204				Sale				73.8291				7
667, L.P.			12/10/2018				1,185				Sale				73.8291				7
Baker Brothers Life Sciences, L.P.			12/10/2018				7,718				Sale				73.8291				7
Baker/Tisch Investments, L.P.			12/11/2018				597				Sale				74.8839				8
Baker Bros. Investments II, L.P.			12/11/2018				41				Sale				74.8839				8
Baker Bros. Investments, L.P.			12/11/2018				534				Sale				74.8839				8
14159, L.P.			12/11/2018				921				Sale				74.8839				8
667, L.P.			12/11/2018				5,342				Sale				74.8839				8
Baker Brothers Life Sciences, L.P.			12/11/2018				34,794				Sale				74.8839				8
Baker/Tisch Investments, L.P.			12/11/2018				216				Sale				71.8141				9
Baker Bros. Investments II, L.P.			12/11/2018				15				Sale				71.8141				9
Baker Bros. Investments, L.P.			12/11/2018				194				Sale				71.8141				9
14159, L.P.			12/11/2018				334				Sale				71.8141				9
667, L.P.			12/11/2018				1,939				Sale				71.8141				9
Baker Brothers Life Sciences, L.P.			12/11/2018				12,627				Sale				71.8141				9

 

Name		Date				Number of Shares				Transaction				Price/Share				Footnotes
Baker/Tisch Investments, L.P.			12/12/2018				262				Sale				73.0858				10
Baker Bros. Investments II, L.P.			12/12/2018				18				Sale				73.0858				10
Baker Bros. Investments, L.P.			12/12/2018				234				Sale				73.0858				10
14159, L.P.			12/12/2018				403				Sale				73.0858				10
667, L.P.			12/12/2018				2,340				Sale				73.0858				10
Baker Brothers Life Sciences, L.P.			12/12/2018				15,243				Sale				73.0858				10
Baker/Tisch Investments, L.P.			1/10/2019				144				Sale				70.2779				11
Baker Bros. Investments II, L.P.			1/10/2019				10				Sale				70.2779				11
Baker Bros. Investments, L.P.			1/10/2019				129				Sale				70.2779				11
14159, L.P.			1/10/2019				222				Sale				70.2779				11
667, L.P.			1/10/2019				1,288				Sale				70.2779				11
Baker Brothers Life Sciences, L.P.			1/10/2019				8,392				Sale				70.2779				11
Baker/Tisch Investments, L.P.			1/11/2019				402				Sale				70.2231				12
Baker Bros. Investments II, L.P.			1/11/2019				27				Sale				70.2231				12
Baker Bros. Investments, L.P.			1/11/2019				360				Sale				70.2231				12
14159, L.P.			1/11/2019				621				Sale				70.2231				12
667, L.P.			1/11/2019				3,602				Sale				70.2231				12
Baker Brothers Life Sciences, L.P.			1/11/2019				23,462				Sale				70.2231				12
Baker/Tisch Investments, L.P.			1/14/2019				9				Sale				70.0717				13
Baker Bros. Investments II, L.P.			1/14/2019				1				Sale				70.0717				13
Baker Bros. Investments, L.P.			1/14/2019				8				Sale				70.0717				13
14159, L.P.			1/14/2019				13				Sale				70.0717				13
667, L.P.			1/14/2019				76				Sale				70.0717				13
Baker Brothers Life Sciences, L.P.			1/14/2019				493				Sale				70.0717				13
Baker/Tisch Investments, L.P.			1/17/2019				2,566				Sale				70.7914				14
Baker Bros. Investments II, L.P.			1/17/2019				175				Sale				70.7914				14
Baker Bros. Investments, L.P.			1/17/2019				2,298				Sale				70.7914				14
14159, L.P.			1/17/2019				3,963				Sale				70.7914				14
667, L.P.			1/17/2019				22,991				Sale				70.7914				14
Baker Brothers Life Sciences, L.P.			1/17/2019				149,754				Sale				70.7914				14
Baker/Tisch Investments, L.P.			1/18/2019				2,268				Sale				72.7864				15
Baker Bros. Investments II, L.P.			1/18/2019				155				Sale				72.7864				15
Baker Bros. Investments, L.P.			1/18/2019				2,031				Sale				72.7864				15
14159, L.P.			1/18/2019				3,503				Sale				72.7864				15
667, L.P.			1/18/2019				20,322				Sale				72.7864				15
Baker Brothers Life Sciences, L.P.			1/18/2019				132,363				Sale				72.7864				15
Baker/Tisch Investments, L.P.			1/18/2019				233				Sale				72.2298				16
Baker Bros. Investments II, L.P.			1/18/2019				16				Sale				72.2298				16
Baker Bros. Investments, L.P.			1/18/2019				209				Sale				72.2298				16
14159, L.P.			1/18/2019				360				Sale				72.2298				16
667, L.P.			1/18/2019				2,087				Sale				72.2298				16
Baker Brothers Life Sciences, L.P.			1/18/2019				13,595				Sale				72.2298				16
Baker/Tisch Investments, L.P.			1/22/2019				181				Sale				71.6126				17
Baker Bros. Investments II, L.P.			1/22/2019				12				Sale				71.6126				17
Baker Bros. Investments, L.P.			1/22/2019				162				Sale				71.6126				17
14159, L.P.			1/22/2019				279				Sale				71.6126				17
667, L.P.			1/22/2019				1,619				Sale				71.6126				17
Baker Brothers Life Sciences, L.P.			1/22/2019				10,547				Sale				71.6126				17
Baker/Tisch Investments, L.P.			1/22/2019				729				Sale				71.0001				18
Baker Bros. Investments II, L.P.			1/22/2019				50				Sale				71.0001				18
Baker Bros. Investments, L.P.			1/22/2019				652				Sale				71.0001				18
14159, L.P.			1/22/2019				1,125				Sale				71.0001				18
667, L.P.			1/22/2019				6,529				Sale				71.0001				18
Baker Brothers Life Sciences, L.P.			1/22/2019				42,521				Sale				71.0001				18

 

(1)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $77.10 to $77.13. The Reporting Persons undertake to provide the staff of the Securities and Exchange Commission (the “Staff”), upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(2)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $75.64 to $75.97. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(3)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $73.68 to $74.36. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(4)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $77.14 to $78.13. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(5)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $75.39 to $75.73. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(6)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $75.69 to $76.29. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(7)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $73.50 to $74.01. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

 

(8)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $74.48 to $75.29. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(9)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $71.60 to $71.92. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(10)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $72.70 to $73.65. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(11)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $70.22 to $70.45. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(12)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $70.00 to $70.57. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(13)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $70.05 to $70.13. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(14)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $70.55 to $71.24. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(15)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $72.66 to $73.57. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(16)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $71.99 to $72.55. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(17)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $71.12 to $72.08. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(18)

The reported price is a weighted average price. These shares were traded in multiple transactions at prices ranging from $71.00 to $71.02. The Reporting Persons undertake to provide the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.

 

(d) Certain securities of the Issuer are held directly by 667, a limited partnership the sole general partner of which is Baker Biotech Capital, L.P., a limited partnership the sole general partner of which is Baker Biotech Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Biotech Capital (GP), LLC.

 

Certain securities of the Issuer are held directly by Life Sciences, a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital, L.P., a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Brothers Life Sciences Capital (GP), LLC.

 

Certain securities of the Issuer are held directly by 14159, a limited partnership the sole general partner of which is 14159 Capital, L.P., a limited partnership the sole general partner of which is 14159 Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of 14159 Capital (GP), LLC.

 

Certain securities of the Issuer are held directly by FBB, a general partnership of which the sole members are Julian C. Baker and Felix J. Baker.

 

Certain securities of the Issuer are held directly by Baker Bros. Investments, a limited partnership the sole general partner of which is Baker Bros. Capital, L.P., a limited partnership the sole general partner of which is Baker Bros. Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Bros. Capital (GP), LLC.

 

 

Certain securities of the Issuer are held directly by Baker Bros. Investments II, a limited partnership the sole general partner of which is Baker Bros. Capital, L.P., a limited partnership the sole general partner of which is Baker Bros. Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Bros. Capital (GP), LLC.

 

Certain securities of the Issuer are held directly by Baker Tisch, a limited partnership the sole general partner of which is Baker/Tisch Capital, L.P., a limited partnership the sole general partner of which is Baker/Tisch Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker/Tisch Capital (GP), LLC.

 

(e)

Not applicable.

 

 

SIGNATURE

 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

January 22, 2019

 

	BAKER BROS. ADVISORS LP   By: Baker Bros. Advisors (GP) LLC, its general partner
	By:	/s/ Scott L. Lessing
		Name: Scott L. Lessing Title: President

 

	BAKER BROS. ADVISORS (GP) LLC
	By:	/s/ Scott L. Lessing
		Name: Scott L. Lessing Title: President

 

	/s/ Julian C. Baker
	Julian C. Baker
	/s/ Felix J. Baker
	Felix J. Baker

 

	FBB Associates
	By:	/s/ Julian C. Baker
		Name: Julian C. Baker Title: Partner