Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Mehra Anand
  2. Issuer Name and Ticker or Trading Symbol
MARINUS PHARMACEUTICALS INC [MRNS]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O SOFINNOVA VENTURES, 3000 SAND HILL ROAD, 4-250
3. Date of Earliest Transaction (Month/Day/Year)
10/20/2016
(Street)

MENLO PARK, CA 94025
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 10/20/2016   S   724,788 D $ 1.389 1,134,851 I See footnote (1)
Common Stock 10/20/2016   S   13,367 D $ 1.389 224,845 I See footnote (2)
Common Stock 10/20/2016   S   12,528 D $ 1.389 15,470 I See footnote (3)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Mehra Anand
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
SOFINNOVA VENTURE PARTNERS VI L P
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
Sofinnova Venture Partners VI GmbH & Co. KG
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
Sofinnova Venture Affiliates VI LP
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
Sofinnova Management VI, L.L.C.
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
Buatois Eric
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
HEALY JAMES
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
Azan Alain
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    
POWELL MICHAEL
C/O SOFINNOVA VENTURES
3000 SAND HILL ROAD, 4-250
MENLO PARK, CA 94025
    X    

Signatures

 /s/ Nathalie Auber, attorney-in-fact for Anand Mehra   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Sofinnova Venture Partners VI, L.P.   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Sofinnova Venture Partners VI GmbH & Co. KG   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Sofinnova Venture Affiliates VI, L.P.   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Sofinnova Management VI, L.L.C.   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Alain Azan   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Eric Buatois   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for James Healy   10/24/2016
**Signature of Reporting Person Date

 /s/ Nathalie Auber, Attorney-in-Fact for Michael Powell   10/24/2016
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares are held by Sofinnova Venture Partners VI, L.P. ("SVP VI"). Sofinnova Management VI, L.L.C. ("SM VI") is the general partner of SVP VI and James I. Healy ("Healy"), Michael F. Powell ("Powell"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SM VI, and Anand Mehra ("Mehra"), a former director of the Issuer, may be deemed to share voting and dispositive power over the shares held by such entities.
(2) Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SVP KG"). SM VI is the managing limited partner of SVP KG, and Healy, Powell, Azan and Buatois, the managing members of SM VI, and Mehra, a former director of the Issuer, may be deemed to share voting and dispositive power over the shares held by such entities.
(3) Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SVA VI"). SM VI is the general partner of SVA VI, and Healy, Powell, Azan and Buatois, the managing members of SM VI, and Mehra, a former director of the Issuer, may be deemed to share voting and dispositive power over the shares held by such entities.

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