SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                (RULE 13d - 102)

  INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND
             (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b)

                               (Amendment No. 1)*

                           Exact Sciences Corporation
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)

                                    30063P105
                                 (CUSIP Number)

                                December 31, 2005
             (Date of Event which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [x] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                       (Continued on the Following Pages)



1.       NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                Paloma International L.P.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                (a)      [x]
                (b)      [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

                Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.       SOLE VOTING POWER

                0

6.       SHARED VOTING POWER

                1,712,730

7.       SOLE DISPOSITIVE POWER

                0

8.       SHARED DISPOSITIVE POWER

                1,712,730

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                1,712,730

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
         EXCLUDES CERTAIN SHARES*   [ ]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                6.51%

12.      TYPE OF REPORTING PERSON*

                PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


1.       NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                S. Donald Sussman

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a)    [x]
         (b)    [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

                United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.       SOLE VOTING POWER

                0

6.       SHARED VOTING POWER

                1,712,730

7.       SOLE DISPOSITIVE POWER

                0

8.       SHARED DISPOSITIVE POWER

                1,712,730

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                1,712,730

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
         EXCLUDES CERTAIN SHARES*   [ ]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                6.51%

12.      TYPE OF REPORTING PERSON*

                IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.       NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                MAK Capital One L.L.C.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a)      [x]
         (b)      [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

                Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.       SOLE VOTING POWER

                0

6.       SHARED VOTING POWER

                1,712,730

7.       SOLE DISPOSITIVE POWER

                0

8.       SHARED DISPOSITIVE POWER

                1,712,730

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                1,712,730

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
         EXCLUDES CERTAIN SHARES*   [ ]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                6.51%

12.      TYPE OF REPORTING PERSON*

                PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


1.       NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                MAK Capital Fund LP

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a)      [x]
         (b)      [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

                Bermuda

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.       SOLE VOTING POWER

                0

6.       SHARED VOTING POWER

                128,280

7.       SOLE DISPOSITIVE POWER

                0

8.       SHARED DISPOSITIVE POWER

                128,280

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                128,280

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
         EXCLUDES CERTAIN SHARES*   [ ]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                0.49%

12.      TYPE OF REPORTING PERSON*

                PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


1.       NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                  Michael A. Kaufman

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a)      [x]
         (b)      [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

                  United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.       SOLE VOTING POWER

                  0

6.       SHARED VOTING POWER

                  1,841,010

7.       SOLE DISPOSITIVE POWER

                  0

8.       SHARED DISPOSITIVE POWER

                  1,841,010

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                  1,841,010

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
         EXCLUDES CERTAIN SHARES*   [ ]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                  6.99%

12.      TYPE OF REPORTING PERSON*

                  IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


     This  statement  is filed  pursuant to Rule  13d-2(b)  with  respect to the
Common Stock, $.01 par value (the "Common Stock"), of Exact Sciences Corporation
(the "Issuer")  beneficially  owned by the Reporting Persons specified herein as
of December 31, 2005, and amends and supplements the Schedule 13G dated December
27, 2005 filed by the  Reporting  Persons (the  "Schedule  13G").  Except as set
forth herein, the Schedule 13G is unmodified.

Item 4.   Ownership.

     Provide  the  following  information  regarding  the  aggregate  number and
percentage of the class of securities of the issuer identified in Item 1.

          (a)     Amount beneficially owned:

                  The Reporting Persons collectively beneficially own 1,841,010
                  shares of Common Stock.

          (b)     Percent of class:

                  The Reporting Persons have beneficial ownership of 1,841,010
                  shares of Common Stock constituting 6.99% of all of the
                  outstanding shares of Common Stock.

          (c)     Number of shares as to which such person has:

                  (i)  Sole power to vote or to direct the vote

                  Not applicable.

                  (ii)  Shared power to vote or to direct the vote

                  Paloma, Mr. Sussman, MAK Capital and Mr. Kaufman have shared
                  power to vote or direct the vote of the 1,712,730 shares of
                  Common Stock owned by Paloma.

                  MAK Fund and Mr. Kaufman have shared power to vote or direct
                  the vote of the 128,280 shares of Common Stock owned by
                  MAK Fund.

                  (iii)  Sole power to dispose or to direct the disposition of

                   Not applicable.

                  (iv)  Shared power to dispose or to direct the disposition of

                  Paloma, Mr. Sussman, MAK Capital and Mr. Kaufman have shared
                  power to dispose or direct the disposition of the 1,712,730
                  shares of Common Stock owned by Paloma.

                  MAK Fund and Mr. Kaufman have shared power to dispose or
                  direct the disposition of the 128,280 shares of Common Stock
                  owned by MAK Fund.

Item 7.   Identification and Classification of the Subsidiary Which Acquired
          the Security Being Reported on by the Parent Holding Company.

     Paloma holds its 1,712,730 shares of Common Stock that it beneficially owns
     through its wholly-owned subsidiary,  Sunrise Partners Limited Partnership,
     a Delaware limited partnership.


Item 10.  Certification.

     By  signing  below  the  undersigned  certifies  that,  to the  best of its
     knowledge and belief,  the  securities  referred to above were not acquired
     and are not held for the  purpose  of or with the  effect  of  changing  or
     influencing  the  control  of the  issuer  of the  securities  and were not
     acquired and are not held in  connection  with or as a  participant  in any
     transaction having that purpose or effect.



                                   SIGNATURES

     After reasonable inquiry and to the best of its knowledge and belief, each
of the undersigned  certifies that the information  with respect to it set forth
in this statement is true, complete, and correct.


Dated:  February 14, 2006

          PALOMA INTERNATIONAL L.P.
          By: Paloma Partners Company L.L.C., general partner


                   By: /s/Michael J. Berner
                       ------------------------
                       Michael J. Berner
                       Vice President


          /s/S. Donald Sussman
          -------------------------------------
                   S. Donald Sussman


         MAK CAPITAL ONE L.L.C.


                   By: /s/Michael A. Kaufman
                       ------------------------
                       Michael A. Kaufman,
                       Managing Member


         MAK CAPITAL FUND LP
         By: MAK GP LLC, general partner


                   By: /s/Michael A. Kaufman
                       -------------------------
                       Michael A. Kaufman,
                       Managing Member


          /s/Michael A. Kaufman
          -------------------------------------
                   Michael A. Kaufman