The markets opened mixed with the Dow losing 17 points to 12,101 while Nasdaq rose 4 points to 2751 as investors monitored developments in Europe.

On the upside

Auxilium Pharmaceuticals (Nasdaq: AUXL) reported positive results from two late stage clinical trials of its Peyronie’s disease treatment Xiaflex.

Galena Biopharma (Nasdaq: GALE) reported upbeat results from a Phase 1/2 clinical trial of its NeuVax vaccine.

Cleveland BioLabs (Nasdaq: CBLI) reported strong survival results from a Good Laboratory Practice efficacy study of its CBLB502.

On the downside

Roth Capital lowered its price target on Dendreon (Nasdaq: DNDN) from $12 to $6.70 saying that the biotechnology firm’s prostate cancer treatment Provenge may lose market share.

Delta Air Lines (NYSE: DAL) reported a smaller than expected 6% gain in May passenger unit revenue.

A Seeking Alpha contributor listed MEMC Electronic Materials (NYSE: WFR) as the worst performing Russell 1000 stock in May.

In the broad market, declining issues outpaced advancers by a margin of nearly 5 to 4 on the NYSE while advancers edged out decliners by 9 to 7 on Nasdaq. The Russell 2000 which tracks small cap stocks added 2 points to 739.