===============================================================================

                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G


                   Under the Securities Exchange Act of 1934
                               (Amendment No. _)*


                                REPLIDYNE, INC.
                                (Name of Issuer)


                    COMMON STOCK, PAR VALUE $0.001 PER SHARE
                         (Title of Class of Securities)


                                   76028W107
                                 (CUSIP Number)

                               DECEMBER 31, 2006
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

         [_]      Rule 13d-1(b)
         [_]      Rule 13d-1(c)
         [X]      Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the reminder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).

===============================================================================


CUSIP NO. 76028W107             Schedule 13G                     Page  2 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person    Perseus-Soros BioPharmaceutical Fund, LP
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               1,368,382
Beneficially            (6)     Shared Voting Power             0
Owned by Each           (7)     Sole Dispositive Power          1,368,382
Reporting Person        (8)     Shared Dispositive Power        0
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,368,382
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               PN

--------------------------------------------------------------------------------


CUSIP NO. 76028W107             Schedule 13G                     Page  3 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person            Perseus-Soros Partners, LLC
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               1,368,382
Beneficially            (6)     Shared Voting Power             0
Owned by Each           (7)     Sole Dispositive Power          1,368,382
Reporting Person        (8)     Shared Dispositive Power        0
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,368,382
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               OO

--------------------------------------------------------------------------------


CUSIP NO. 76028W107             Schedule 13G                     Page  4 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person        Perseus BioTech Fund Partners, LLC
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,368,382
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,368,382
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,368,382
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               OO

--------------------------------------------------------------------------------


CUSIP NO. 76028W107             Schedule 13G                     Page  5 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person                SFM Participation, L.P.
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,368,382
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,368,382
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,368,382
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9       5.1%

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               PN

--------------------------------------------------------------------------------


CUSIP NO. 76028W107             Schedule 13G                     Page  6 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person               SFM AH LLC
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,368,382
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,368,382
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,368,382
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               OO

--------------------------------------------------------------------------------


CUSIP NO. 76028W107             Schedule 13G                     Page  7 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person               Perseuspur, LLC
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,368,382
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,368,382
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,368,382
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               OO

--------------------------------------------------------------------------------


CUSIP NO. 76028W107             Schedule 13G                     Page  8 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person        Frank H. Pearl
         S.S. or I.R.S. Identifica-      (in the capacity described herein)
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           United States

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,384,695*
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,384,695*
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,384,695*
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%*

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               IN

--------------------------------------------------------------------------------

* Includes 16,313 shares of common stock issuable upon the exercise of stock
options. The stock options are held for the benefit of an entity controlled by
affiliates of the Perseus-Soros BioPharmaceutical Fund, LP.


CUSIP NO. 76028W107             Schedule 13G                     Page  9 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person       George Soros
         S.S. or I.R.S. Identifica-     (in the capacity described herein)
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           United States

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,384,695*
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,384,695*
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,384,695*
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%*

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               IA

--------------------------------------------------------------------------------

* Includes 16,313 shares of common stock issuable upon the exercise of stock
options. The stock options are held for the benefit of an entity controlled by
affiliates of the Perseus-Soros BioPharmaceutical Fund, LP.



CUSIP NO. 76028W107             Schedule 13G                     Page  10 of 24


--------------------------------------------------------------------------------
1.       Name of Reporting Person         Soros Fund Management LLC
         S.S. or I.R.S. Identifica-
         tion No. of Above Person

--------------------------------------------------------------------------------
2.       Check the Appropriate Box                              (a)     [_]
         if a Member of a Group                                 (b)     [X]

--------------------------------------------------------------------------------
3.       S.E.C. Use Only

--------------------------------------------------------------------------------
4.       Citizenship or Place of Organization           Delaware

--------------------------------------------------------------------------------
Number of Shares        (5)     Sole Voting Power               0
Beneficially            (6)     Shared Voting Power             1,384,695*
Owned by Each           (7)     Sole Dispositive Power          0
Reporting Person        (8)     Shared Dispositive Power        1,384,695*
--------------------------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,384,695*
--------------------------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes Certain
         Shares
                                                                        [_]
--------------------------------------------------------------------------------
11.      Percent of Class Represented by Amount in Row 9        5.1%*

--------------------------------------------------------------------------------
12.      Type of Reporting Person                               OO; IA

--------------------------------------------------------------------------------

* Includes 16,313 shares of common stock issuable upon the exercise of stock
options. The stock options are held for the benefit of an entity controlled by
affiliates of the Perseus-Soros BioPharmaceutical Fund, LP.



CUSIP NO. 76028W107             Schedule 13G                     Page  11 of 24


Item 1.       (a)    NAME OF ISSUER

                     Replidyne, Inc. (the "Company").

              (b)    ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

                     1450 Infinite Drive
                     Louisville, CO 80027

Item 2.       (a)    NAMES OF PERSONS FILING

                            This  Statement is being filed on behalf of each of
                     the  following  persons   (collectively,   the  "Reporting
                     Persons")

                     (i)    Perseus-Soros   BioPharmaceutical   Fund,   LP,   a
                            Delaware limited partnership ("Perseus-Soros");

                     (ii)   Perseus-Soros  Partners,  LLC, a  Delaware  limited
                            liability  company ("PSP GP" and general partner of
                            Perseus-Soros);

                     (iii)  Perseus  BioTech  Fund  Partners,  LLC,  a Delaware
                            limited  liability  company  ("PBFP  Partners"  and
                            managing member of PSP GP);

                     (iv)   SFM   Participation,   L.P.,  a  Delaware   limited
                            partnership  ("SFM   Participation"   and  managing
                            member of PSP GP);

                     (v)    SFM AH LLC, a Delaware  limited  liability  company
                            ("SFM   AH"   and    general    partner    of   SFM
                            Participation);

                     (vi)   Perseuspur,   LLC,  a  Delaware  limited  liability
                            company  ("Perseuspur"  and managing member of PBFP
                            Partners);

                     (vii)  Mr. Frank H. Pearl ("Mr.  Pearl" and sole member of
                            Perseuspur);

                     (viii) Mr.  George Soros ("Mr.  Soros" and Chairman of SFM
                            LLC); and

                     (ix)   Soros  Fund  Management  LLC,  a  Delaware  limited
                            liability  company ("SFM LLC" and the sole managing
                            member of SFM AH).



CUSIP NO. 76028W107             Schedule 13G                     Page  12 of 24


              (b)    ADDRESS OF PRINCIPAL BUSINESS OFFICE

                     The  address  of the  principal  business  offices  of (i)
                     Perseus-Soros and (ii) PSP, GP is 888 Seventh Avenue, 30th
                     Floor, New York, NY 10106.

                     The address of the principal  business offices of (i) PBFP
                     Partners,  (ii)  Perseuspur  and (iii)  Mr.  Pearl is 2099
                     Pennsylvania  Ave.,  N.W.,  Suite  900,  Washington,  D.C.
                     20006.

                     The address of the principal  business  offices of (i) SFM
                     Participation,  (ii)  SFM AH,  (iii)  SFM LLC and (iv) Mr.
                     Soros is 888  Seventh  Avenue,  33rd Floor,  New York,  NY
                     10106.

              (c)    CITIZENSHIP

                     (i)    Perseus-Soros - a Delaware limited partnership

                     (ii)   PSP GP - a Delaware limited liability company

                     (iii)  PBFP Partners - a Delaware limited liability company

                     (iv)   SFM Participation - a Delaware limited partnership

                     (v)    SFM AH - a Delaware limited liability company

                     (vi)   Perseuspur -  Delaware limited liability company

                     (vii)  Mr. Pearl - United States

                     (viii) Mr. Soros - United States

                     (ix)   SFM LLC - a Delaware limited liability company

              (d)    TITLE OF CLASS OF SECURITIES

                     Common  Stock,  par value  $0.001 per share  (the  "Common
                     Stock" or "Shares")

              (e)    CUSIP NUMBER

                     76028W107

                     Information contained herein concerning SFM Participation,
                     SFM AH,  SFM LLC and Mr.  Soros has been  provided  by SFM
                     LLC. Perseus-Soros,  PSP GP, PBFP Partners, Perseuspur and
                     Mr. Pearl assume no  responsibility  for such information.
                     Information  contained  herein  concerning  PBFP Partners,
                     Perseuspur  and Mr.  Pearl has been  provided by each such
                     Reporting    Person.    Perseus-Soros,    PSP   GP,    SFM
                     Participation,  SFM AH,  SFM LLC and Mr.  Soros  assume no
                     responsibility for such information.



CUSIP NO. 76028W107             Schedule 13G                     Page  13 of 24


Item 3.       This  statement  is not  being  filed  pursuant  to  either  Rule
              13d-1(b) or 13d-2(b) or (c).

Item 4.       OWNERSHIP.

              (a)    AMOUNT BENEFICIALLY OWNED:

                     Each of the Reporting  Persons  other than Mr. Soros,  Mr.
                     Pearl  and SFM  LLC  may be  deemed  to  beneficially  own
                     1,368,382 Shares.

                     Each of Mr. Soros,  Mr. Pearl and SFM LLC may be deemed to
                     beneficially   own  an  aggregate  of  1,384,695   Shares,
                     including  16,313 shares of common stock issuable upon the
                     exercise of stock options.  The stock options are held for
                     the benefit of an entity  controlled  by affiliates of the
                     Perseus-Soros BioPharmaceutical Fund, LP.

              (b)    PERCENTAGE OWNED:

                     Based  on  calculations   made  in  accordance  with  Rule
                     13d-3(d), and there being 26,935,680 Shares outstanding as
                     of October 31, 2006, each of the Reporting  Persons may be
                     deemed  to  beneficially  own  approximately  5.1%  of the
                     outstanding Common Stock.

              (c)    NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS:

                     (i) Each of Perseus-Soros and PSP GP may be deemed to have
                     sole power to direct the  voting  and  disposition  of the
                     1,368,382  Shares  beneficially  owned  by  Perseus-Soros.

                     (ii) By virtue of the relationships  between and among the
                     Reporting Persons as described in Item 2, each of:

                     (a) PBFP Partners,  Perseuspur,  SFM Participation and SFM
                     AH may be deemed to share the power to direct  the  voting
                     and disposition of 1,368,382 Shares  beneficially owned by
                     Perseus-Soros and (b) each of Mr. Soros, Mr. Pearl and SFM
                     LLC may be deemed to share the power to direct  the voting
                     and disposition of the 1,368,382 Shares beneficially owned
                     by Perseus-Soros,  and the 16,313 Shares issuable upon the
                     exercise of stock options.  The stock options are held for
                     the benefit of an entity  controlled  by affiliates of the
                     Perseus-Soros BioPharmaceutical Fund, LP.

Item 5.       OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

              Not applicable.

Item 6.       OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

              The partners of  Perseus-Soros  have the right to  participate in
              the receipt of dividends  from, or proceeds from the sale of, the



CUSIP NO. 76028W107             Schedule 13G                     Page  14 of 24


              securities  held for the account of  Perseus-Soros  in accordance
              with their ownership interests in Perseus-Soros.

Item 7.       IDENTIFICATION  AND  CLASSIFICATION  OF SUBSIDIARY WHICH ACQUIRED
              THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

              Not applicable.

Item 8.       IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

              Not applicable.

Item 9.       NOTICE OF DISSOLUTION OF GROUP

              Not applicable.

Item 10.      CERTIFICATION

              Not applicable.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]





CUSIP NO. 76028W107             Schedule 13G                     Page  15 of 24


                                  SIGNATURES

              After  reasonable  inquiry and to the best of our  knowledge  and
belief,  the  undersigned  certify  that  the  information  set  forth  in this
statement is true, complete and correct.

Dated as of February 13, 2007

                                    PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP


                                    By: Perseus-Soros Partners, LLC
                                        General Partner


                                    By: SFM Participation, L.P.
                                        Managing Member


                                    By: SFM AH LLC
                                        General Partner


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel



CUSIP NO. 76028W107             Schedule 13G                     Page  16 of 24


                                    PERSEUS-SOROS PARTNERS, LLC


                                    By: SFM Participation, L.P.
                                        Managing Member


                                    By: SFM AH LLC
                                        General Partner


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel



                                    PERSEUS BIOTECH FUND PARTNERS, LLC


                                    By: Perseuspur, LLC
                                        Member


                                    By: /s/ Rodd Macklin
                                        ---------------------------------------
                                        Name:   Rodd Macklin
                                        Title:  Secretary and Treasurer




CUSIP NO. 76028W107             Schedule 13G                     Page  17 of 24


                                    SFM PARTICIPATION, L.P.


                                    By: SFM AH LLC
                                        General Partner


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel

                                    SFM AH LLC


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel


                                    PERSEUSPUR, LLC


                                    By: /s/ Rodd Macklin
                                        ---------------------------------------
                                        Name:   Rodd Macklin
                                        Title:  Secretary and Treasurer




CUSIP NO. 76028W107             Schedule 13G                     Page  18 of 24



                                    MR. FRANK H. PEARL


                                    By: /s/ Rodd Macklin
                                        ---------------------------------------
                                        Name:   Rodd Macklin
                                        Title:  Attorney-in-Fact


                                    MR. GEORGE SOROS


                                    By: /s/  Jodye M. Anzalotta
                                        ----------------------------------------
                                        Name:   Jodye M. Anzalotta
                                        Title:  Attorney-in-Fact


                                   SOROS FUND MANAGEMENT LLC


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel






CUSIP NO. 76028W107             Schedule 13G                     Page  19 of 24


                                  EXHIBIT INDEX
                                  -------------

Exhibit 1.        Joint Filing Agreement as required by Rule 13d-1(k)(1)  under
                  the Securities Exchange Act of 1934, as amended.

Exhibit 2.        Power of  Attorney,  dated June 16, 2005  appointing  each of
                  Armando T. Belly,  Jodye  Anzalotta,  Maryann  Canfield,  Jay
                  Schoenfarber and Robert Soros as Attorney-In-Fact  for George
                  Soros.

Exhibit 3.        Power of  Attorney,  dated  April 9,  2003,  appointing  Rodd
                  Macklin as Attorney-in-Fact for Frank H. Pearl.






CUSIP NO. 76028W107             Schedule 13G                     Page  20 of 24


                                                                      EXHIBIT 1


              JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1)

              The   undersigned   acknowledge  and  agree  that  the  foregoing
statement  on Schedule  13G is filed on behalf of each of the  undersigned  and
that all subsequent amendments to this statement on Schedule 13G shall be filed
on behalf of each of the undersigned without the necessity of filing additional
joint  filing  statements.  The  undersigned  acknowledge  that  each  shall be
responsible for the timely filing of such amendments,  and for the completeness
and accuracy of the information concerning him, her or it contained herein, but
shall not be responsible for the  completeness  and accuracy of the information
concerning the other entities or persons,  except to the extent that he, she or
it knows or has reason to believe that such information is inaccurate.

Dated as of February 13, 2007

                                    PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP


                                    By: Perseus-Soros Partners, LLC
                                        General Partner


                                    By: SFM Participation, L.P.
                                        Managing Member


                                    By: SFM AH LLC
                                        General Partner


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel



CUSIP NO. 76028W107             Schedule 13G                     Page  21 of 24


                                    PERSEUS-SOROS PARTNERS, LLC


                                    By: SFM Participation, L.P.
                                        Managing Member


                                    By: SFM AH LLC
                                        General Partner


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel



                                    PERSEUS BIOTECH FUND PARTNERS, LLC


                                    By: Perseuspur, LLC
                                        Member


                                    By: /s/ Rodd Macklin
                                        ---------------------------------------
                                        Name:   Rodd Macklin
                                        Title:  Secretary and Treasurer


                                    SFM PARTICIPATION, L.P.


                                    By: SFM AH LLC
                                        General Partner


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel




CUSIP NO. 76028W107             Schedule 13G                     Page  22 of 24


                                    SFM AH LLC


                                    By: Soros Fund Management LLC
                                        Managing Member


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel


                                    PERSEUSPUR, LLC


                                    By: /s/ Rodd Macklin
                                        ---------------------------------------
                                        Name:   Rodd Macklin
                                        Title:  Secretary and Treasurer


                                    MR. FRANK H. PEARL


                                    By: /s/ Rodd Macklin
                                        ---------------------------------------
                                        Name:   Rodd Macklin
                                        Title:  Attorney-in-Fact


                                    MR. GEORGE SOROS


                                    By: /s/  Jodye M. Anzalotta
                                        ----------------------------------------
                                        Name:   Jodye M. Anzalotta
                                        Title:  Attorney-in-Fact


                                   SOROS FUND MANAGEMENT LLC


                                    By:  /s/  Jodye M. Anzalotta
                                         --------------------------------------
                                         Name:   Jodye M. Anzalotta
                                         Title:  Assistant General Counsel





CUSIP NO. 76028W107             Schedule 13G                     Page  23 of 24


                                                                      EXHIBIT 2


                               POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENT,  that I, GEORGE SOROS,  hereby make,  constitute
and appoint each of ARMANDO T. BELLY,  JODYE ANZALOTTA,  MARYANN CANFIELD,  JAY
SCHOENFARBER  and  ROBERT  SOROS,   acting   individually,   as  my  agent  and
attorney-in-fact  for the purpose of executing  in my name,  (a) in my personal
capacity or (b) in my capacity as Chairman of, member of or in other capacities
with  Soros  Fund  Management  LLC ("SFM  LLC") and each of its  affiliates  or
entities  advised by me or SFM LLC, all documents,  certificates,  instruments,
statements,  filings and agreements ("documents") to be filed with or delivered
to any  foreign or  domestic  governmental  or  regulatory  body or required or
requested  by any other  person or entity  pursuant to any legal or  regulatory
requirement relating to the acquisition,  ownership,  management or disposition
of securities,  futures contracts or other investments, and any other documents
relating or ancillary  thereto,  including  without  limitation  all  documents
relating to filings with the Commodity Futures Trading  Commission and National
Futures Association,  the United States Securities and Exchange Commission (the
"SEC") pursuant to the Securities Act of 1933 or the Securities Exchange Act of
1934  (the  "Act")  and  the  rules  and  regulations  promulgated  thereunder,
including  all  documents  relating to the  beneficial  ownership of securities
required to be filed with the SEC pursuant to Section 13(d) or Section 16(a) of
the Act and any  information  statements  on Form 13F required to be filed with
the SEC pursuant to Section 13(f) of the Act.

All past acts of these  attorneys-in-fact  in  furtherance of the foregoing are
hereby ratified and confirmed.

Execution  of this power of attorney  revokes  that  certain  Power of Attorney
dated as of the 11th March  2005 with  respect  to the same  matters  addressed
above.

This power of attorney shall be valid from the date hereof until revoked by me.

IN WITNESS WHEREOF,  I have executed this instrument as of the 16th day of June
2005.


                                                     GEORGE SOROS

                                                     /s/ Daniel Eule
                                                     --------------------------
                                                     Name:    Daniel Eule
                                                     Title:   Attorney-in-Fact



CUSIP NO. 76028W107             Schedule 13G                     Page  24 of 24


                                                                      EXHIBIT 3


                               POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS, that I, FRANK H. PEARL, hereby make, constitute and
appoint  RODD  MACKLIN  as my agent and  attorney-in-fact  for the  purpose  of
executing  in my name,  (a) in my  personal  capacity  or (b) in my capacity as
Chairman of, member of or in other  capacities with Perseus LLC ("PERSEUS") and
each of its  affiliates or entities  advised by me or Perseus,  all  documents,
certificates,  instruments, statements, filings and agreements ("DOCUMENTS") to
be  filed  with  or  delivered  to any  foreign  or  domestic  governmental  or
regulatory body or required or requested by any other person or entity pursuant
to any legal or regulatory requirement relating to the acquisition,  ownership,
management  or  disposition  of  securities,   futures   contracts,   or  other
investments,  and any other documents relating or ancillary thereto,  including
but not limited to, all  documents  relating  to filings  with the  Commodities
Futures Trading Commission and National Futures Association,  the United States
Securities  and Exchange  Commission  (the "SEC")  pursuant to the  Commodities
Exchange Act and the Securities  Act of 1933 or the Securities  Exchange Act of
1934  (the  "Act")  and  the  rules  and  regulations  promulgated  thereunder,
including  all  documents  relating to the  beneficial  ownership of securities
required to be filed with the SEC pursuant to Section 13(d) or Section 16(a) of
the Act and  information  statements  on Form 13F required to be filed with the
SEC pursuant to Section 13(f) of the Act.

All past acts of the  attorney-in-fact  in  furtherance  of the  foregoing  are
hereby ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN WITNESS WHEREOF, I have executed this instrument as of the 9th day of April,
2003.

                                    /s/ Frank H. Pearl
                                    ------------------------------
                                    FRANK H. PEARL