UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 4)*


                         SPECTRUM PHARMACEUTICALS, INC.
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                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   84763A108
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                                 (CUSIP Number)

Mitchell D. Kaye, Manager                            with a copy to:
Xmark Asset Management, LLC                          Steven E. Siesser, Esq.
301 Tresser Boulevard                                Lowenstein Sandler PC
Suite 1320                                           65 Livingston Avenue
Stamford, CT 06901                                   Roseland, New Jersey  07068
(203) 653-2500                                       (973) 597-2506
--------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  June 7, 2005
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.         84763A108    
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons 
   (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
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2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  Not 
         (b)               Applicable
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3.  SEC Use Only
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4.  Source of Funds (See Instructions):  WC
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5.  Check  if  Disclosure of  Legal Proceedings  Is Required  Pursuant  to Items
    2(d) or 2(e):                 Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:   New York, United States

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    Number of                      7. Sole Voting Power:                  *
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:             *
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:          *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:  1,153,342*
--------------------------------------------------------------------------------
12. Check if  the  Aggregate  Amount in  Row (11) Excludes  Certain  Shares (See
    Instructions):
                                X
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   7.5%*
--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):   IA
--------------------------------------------------------------------------------
*   The reporting  person is Xmark Asset  Management,  LLC  ("XAM"),  a New York
limited liability company.  XAM's interest in the securities  reported herein is
limited to its  pecuniary  interest,  if any,  in Xmark Fund,  L.P.,  a Delaware
limited  partnership  ("Xmark  LP"),  and Xmark  Fund,  Ltd.,  a Cayman  Islands
exempted company ("Xmark Ltd").

Xmark LP is the holder of: (i) 565,922  shares (the "Xmark LP Shares") of Common
Stock,   par  value  $0.001  per  share  (the  "Common   Stock"),   of  Spectrum
Pharmaceuticals,  Inc., a Delaware  corporation (the  "Company");  (ii) warrants
(the "2003 Xmark LP Warrants") which,  subject to certain exercise  restrictions
contained  therein,  entitle  Xmark LP to purchase an aggregate of up to 168,000
shares of Common Stock at an exercise  price of $6.50 per share,  which exercise
price is subject to adjustment as set forth in the 2003 Xmark LP Warrants; (iii)
warrants  (the "2004  Xmark LP  Warrants")  which,  subject to certain  exercise
restrictions contained therein,  entitle Xmark LP to purchase an aggregate of up
to 53,666 shares of Common Stock at an exercise price of $10.00 per share, which
exercise  price is  subject  to  adjustment  as set  forth in the 2004  Xmark LP
Warrants;  and (iv) 108 call options  exercisable  into 10,800  shares of Common
Stock at an exercise price of $10.00 per share.

Xmark Ltd is the holder of: (i) 565,920  shares of Common  Stock (the "Xmark Ltd
Shares," and together  with the Xmark LP Shares,  the  "Shares");  (ii) warrants
(the "2003 Xmark Ltd  Warrants,"  and together  with the 2003 Xmark LP Warrants,
the "2003 Warrants") which, subject to certain exercise  restrictions  contained





therein,  entitle Xmark Ltd to purchase an aggregate of up to 252,000  shares of
Common Stock at an exercise  price of $6.50 per share,  which  exercise price is
subject  to  adjustment  as set  forth in the 2003  Xmark  Ltd  Warrants;  (iii)
warrants (the "2004 Xmark Ltd  Warrants,"  and  together  with the 2004 Xmark LP
Warrants,  the "2004 Warrants") which, subject to certain exercise  restrictions
contained  therein,  entitle  Xmark Ltd to purchase an aggregate of up to 51,335
shares of Common Stock at an exercise price of $10.00 per share,  which exercise
price is subject to adjustment as set forth in the 2004 Xmark Ltd Warrants;  and
(iv) 107 call  options  exercisable  into  10,700  shares of Common  Stock at an
exercise price of $10.00 per share.

The 2003 Warrants and the 2004 Warrants each provide that in no event shall such
warrants  be  exercisable  for  shares of Common  Stock to the  extent  that the
issuance of Common Stock thereunder  would result in the "beneficial  ownership"
(as defined in Section 13(d) of the Securities Exchange Act of 1934, as amended,
and Regulations  13D-G  thereunder) by Xmark LP, Xmark Ltd, or their affiliates,
of more than 4.95% and 4.99%,  respectively,  of the Common Stock (the "Issuance
Limitation").  The Issuance Limitation may not be waived.

XAM serves as  investment  manager  for each of Xmark LP and Xmark Ltd.  In such
capacity,  XAM  possesses  the power to vote and direct the  disposition  of all
securities  held by Xmark LP and  Xmark  Ltd.  Thus,  as of June 7, 2005 for the
purposes  of Reg. Section  240.13d-3,  XAM  may be  deemed to  beneficially  own
1,153,342  shares of Common Stock, or 7.5% of the Common Stock deemed issued and
outstanding as of that date.  Two XAM affiliates acquired in the open market and
currently own 50 January 2007 call options with respect to the Common Stock, the
beneficial ownership of which is hereby disclaimed by the Reporting Person.









Item 4.   Purpose of Transaction.
          ----------------------

          As noted in Amendment  No. 3 to this  Schedule  13D, as filed with the
Securities and Exchange  Commission (the  "Commission") on May 20, 2005, XAM has
recently  raised a number of concerns to the board of  directors  of the Company
(the  "Board")  with respect to the  Company's  corporate  governance  and other
matters.  In that amendment,  XAM noted that, while it remains  committed to the
Company and believes in the potential value of its principal business model, XAM
has concerns about the process for setting executive  compensation,  the Board's
determination to reduce the size of the Board from seven to five directors,  the
Board's  role in setting the  strategic  direction  of the  Company,  as well as
certain other matters.

          On June 7, 2005, XAM sent an open letter to other  shareholders of the
Company (the "Letter").  In the Letter, XAM reiterated some of its concerns with
respect to the Company's corporate governance. Among other things, XAM expressed
concern  regarding the  Company's  compensation  scheme,  including the handsome
rewards to  the Company's Chief Executive  Officer in spite of lackluster  stock
price performance.

          In the Letter, XAM also highlighted certain recent communications with
the Board in which,  among other things, (1) XAM questioned the propriety of Dr.
Rajesh  Shrotriya's  compensation  levels,  (2) XAM demanded  further  detail on
compensation  levels than that provided in the  Company's  proxy  statement,  as
filed with the  Commission  on April 29, 2005,  (3) XAM  requested a seat on the
Company's Board in order to add an independent  voice in the boardroom,  and (4)
XAM questioned the Company's recent  strategic  initiatives and asset purchases.
In its Letter,  XAM also announced to fellow  shareholders its intention to vote
against the slate of directors proposed in the Company's proxy.

          Given the  plurality  voting  standard for  electing  directors of the
Company,  the Reporting Person's desire to withhold its proxy cannot result in a
change in the Board. Nevertheless, the Reporting Person is amending its Schedule
13D on a voluntary  basis  because its efforts may further  evolve in the future
into a plan that results in a change in the Board.


Item 5.   Interest in Securities of the Issuer.
          ------------------------------------ 

          Based upon the Company's  Registration Statement on Form S-3, as filed
with the  Commission  on May 25, 2005,  there were  15,352,949  shares of Common
Stock issued and outstanding  as of May 19, 2005.  As of June 7, 2005,  Xmark LP
and Xmark Ltd beneficially own 1,153,342 shares of Common Stock.

          As of June 7, 2005,  Xmark LP is the holder of (i)  565,922  shares of
Common Stock of the Company,  (ii) warrants which,  subject to certain  exercise
restrictions contained therein,  entitle Xmark LP to purchase up to an aggregate
of 168,000  shares of Common Stock at an exercise  price of $6.50 per share (the
"2003 Xmark LP Warrants"),  which exercise price is subject to adjustment as set
forth in the 2003 Xmark LP Warrants,  (iii) warrants  which,  subject to certain
exercise restrictions  contained therein,  entitle Xmark LP to purchase up to an
aggregate of 53,666  shares of Common  Stock at an exercise  price of $10.00 per
share  (the  "2004  Xmark LP  Warrants"),  which  exercise  price is  subject to





adjustment as set forth in the 2004 Xmark LP Warrants, and (iv) 108 call options
exercisable  into 10,800  shares of Common Stock at an exercise  price of $10.00
per share.  Xmark Ltd is the holder of (i) 565,920 shares of Common Stock,  (ii)
warrants which,  subject to certain  exercise  restrictions  contained  therein,
entitle  Xmark Ltd to purchase up to an  aggregate  of 252,000  shares of Common
Stock at an exercise  price of $6.50 per share (the "2003  Xmark Ltd  Warrants,"
and  together  with the 2003  Xmark LP  Warrants,  the "2003  Warrants"),  which
exercise  price is  subject  to  adjustment  as set forth in the 2003  Xmark Ltd
Warrants,  (iii)  warrants  which,  subject  to  certain  exercise  restrictions
contained  therein,  entitle  Xmark Ltd to purchase up to an aggregate of 51,335
shares of Common Stock at an exercise price of $10.00 per share (the "2004 Xmark
Ltd  Warrants",  and  together  with  the  2004  Xmark LP  Warrants,  the  "2004
Warrants"),  which  exercise  price is subject to adjustment as set forth in the
2004 Xmark Ltd  Warrants,  and (iv) 107 call  options  exercisable  into  10,700
shares of Common Stock at an exercise price of $10.00 per share.

          The 2003  Warrants and the 2004 Warrants each provide that in no event
shall such warrants be exercisable for shares of Common Stock to the extent that
the  issuance  of  Common  Stock  thereunder  would  result  in the  "beneficial
ownership" (as defined in Section 13(d) of the Securities  Exchange Act of 1934,
as amended,  and Regulations  13D-G thereunder) by Xmark LP, Xmark Ltd, or their
affiliates, of more than 4.95% and 4.99%, respectively, of the Common Stock (the
"Issuance  Limitation").  The Issuance Limitation may not be waived. Thus, as of
June 7, 2005, for the purposes of Reg. Section  240.13d-3,  XAM may be deemed to
beneficially  own 1,153,342  shares of Common Stock, or 7.5% of the Common Stock
deemed issued and  outstanding as of that date.  Two XAM affiliates  acquired in
the open market and  currently  own 50 January 2007 call options with respect to
the Common Stock, the beneficial  ownership of which is hereby disclaimed by the
Reporting Person.

          The following table details the transactions effected since the filing
of Amendment No. 3 to the Schedule 13D, in Common Stock, by XAM or any person or
entity  controlled by XAM or any person or entity for which XAM possesses voting
or investment control over the securities thereof (each of which was effected in
an ordinary brokerage transaction):


                                   I. Xmark LP
                                   -----------

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------
   05/31/05                            975                      $5.21


                                  II.  Xmark Ltd
                                  --------------

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------
   05/31/05                            975                      $5.21





Item 7.   Material to Be Filed as Exhibits.
          --------------------------------

          1.  Open Letter to Shareholders dated June 7, 2005.









                                    Signature
                                    ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                            June 7, 2005

                                            XMARK ASSET MANAGEMENT, LLC

                                            /s/ Mitchell D. Kaye 
                                            ------------------------------------
                                            Mitchell D. Kaye, Manager


Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).






                                                                    June 7, 2005

Dear Fellow Shareholders:

     We  believe  it is  appropriate  to  expand  upon some  statements  we have
previously made about Spectrum Pharmaceuticals, Inc. and its management.  On May
20, 2005,  we filed an  amendment  to our Schedule 13D (an SEC Form  required of
holders of over 5% of an issuer's shares) and stated:

          XAM has recently raised a number of concerns to the board of
          directors   of  the  Company   with   respect  to  corporate
          governance.  While XAM remains  committed to the Company and
          believes in the potential  value of its  principal  business
          model, XAM expressed  concerns about the process for setting
          executive compensation,  the Board's determination to reduce
          the size of the  Board  from  seven to five  directors,  the
          Board's  role in  setting  the  strategic  direction  of the
          Company, and certain other matters.

While our  commitment  to the Company  remains  strong,  we want to provide more
detail on the concerns  disclosed in our Schedule  13D, and to do what we can as
major  shareholders  to uncover  and correct  practices  that we believe may not
comport with best practices for corporate governance.

     In April of this year,  we wrote to the  directors  of Spectrum  expressing
concern about compensation issues.  In that letter we stated in part:

          In view of the call throughout corporate America for greater
          focus on reasonable  compensation and "pay for performance",
          I would like to draw the committee's attention to some areas
          of  concern.  For the  year-ended  December  31,  2003,  the
          compensation committee rewarded management  handsomely.  Dr.
          Shrotriya as chief  executive  officer  received  salary and
          bonus  of  $818,000,   compared  to  $260,000  in  2002.  In
          addition,  Dr. Shrotriya  received  stock options in 2003 of
          440,000 shares.

          In your  compensation  committee  report,  you explained the
          rationale for the substantial pay raises,  bonuses and stock
          option   grants  by  focusing  on  what  you   perceived  as
          outstanding performance in 2003. In viewing compensation for
          2004, I hope you will continue to focus on performance.

          One area of  critical  focus  should be to note  that  since
          December  31,  2003,  the  per  share  stock  price  of  the
          Company's  common  stock has dropped  from $8.37 on December
          31, 2003 to $6.66 on  December  31, 2004 (a drop of 20%) and





          to  $5.85 as of  yesterday,  April  25,  2005 (a drop of 30%
          since year-end 2003).  This decline in shareholder value has
          taken place in spite of apparent operational progress at the
          Company.  I am troubled  that this  "progress"  has not been
          converted  into  increased  shareholder  value.  To a  large
          degree,  I believe that management must be held  accountable
          for such a disappointing calculus. Until the capital markets
          reward the Company for its  performance,  I believe  that it
          would be inappropriate  for management to be rewarded by the
          compensation  committee  or the Board.  It would be patently
          inconsistent  with the  committee's  stated goal of aligning
          management  and  stockholder  interests for management to be
          rewarded  while the Company's  shareholders  lose money.  Of
          course,  if and when the market  rewards the Company for its
          progress in terms of an increased market valuation,  also it
          would then be appropriate for management to benefit.

          Obviously,  in light of your fiduciary duty to stockholders,
          it is  for  you  -not  us- to  set  executive  compensation.
          However,  based on the  Company's  2004's  performance,  the
          significant  decline  in market  value  which the  Company's
          stockholders  suffered during this past year and the need to
          conserve cash in light of continuing  losses, I would expect
          this to be a year during which significant  bonuses will not
          be awarded.  I would expect other stockholders to share this
          view if asked.

          Further,  while I  understand  the value of officers  having
          equity in the Company to align their interests with those of
          the  shareholders,  I call your  attention  to the fact that
          this  alignment  is  imperfect,  as stock  options only give
          management the opportunity to share the upside,  but not the
          downside, as we have seen this year. As a result of the very
          significant  stock option  grants last  year,  Dr. Shrotriya
          already is the beneficial  owner of  approximately 5% of the
          company's  common  stock.  With  that size  stake,  there is
          substantial  upside  protection,  and I do not believe  that
          further  option grants of any  significance  are required to
          align his  interests  with  that of the other  stockholders,
          particularly in light of the dilution that the  stockholders
          suffered as a result of last year's option grants.  Again, I
          would not be  surprised if this feeling were shared by other
          stockholders.

In response to this  letter,  representatives  of our firm were assured that the
compensation  committee  of the  board  understood  our  position  and would act
appropriately.

     We were then shocked to see Spectrum's  proxy  statement  filed on April 29
and  see its  disclosures  of  compensation  to  Dr. Shrotriya.  We  again  felt
compelled  to write to the board.  We first  asked our  counsel  to request  the
compensation  committee report  referenced in the proxy  statement.  In an email
sent on May 4, our counsel noted:





          To  follow  up  on  our  conversation  last  night  - I  had
          requested  a copy of the  consultant's  report (as my client
          had  previously  requested  of the  company) and we have not
          received it -  Accordingly,  I asked one of my paralegals to
          obtain the  compensation  data from the proxy  statements of
          the companies  that your proxy  statement  referenced as the
          basis for your consultant's  report....  I attach a copy for
          your  reference.  Obviously this work is not  scientific....
          But in short,  your proxy  statement is disingenuous at best
          in suggesting  that Dr.  Shrotriya is paid on level with his
          peers  when  among  the 16  companies,  he is 1st in  salary
          (tie),  2nd in 2004  cash  bonus and 2nd in number of option
          shares  granted in 2004 (but by far 1st in number of options
          granted as a percentage of the outstanding  shares), and all
          of this without including the 500,000 options he was granted
          on January 3, 2005. With that January 3 grant, Dr. Shrotriya
          also now far  exceeds  his peers in  percentage  of  options
          compared to outstanding  shares (he was already tied for 1st
          at 12/31/04 before that grant).

A copy of the chart that we provided to the Company is attached to this  letter.
Although we are not compensation  experts,  we are active investors in companies
like  Spectrum.  We  gathered  the data  contained  in the  enclosed  chart from
publicly  available  sources we reasonably  believe to be reliable.  We have not
independently  verified any of the information contained in the chart. For those
reasons, we urge caution against reliance on the chart and any conclusions drawn
from the  chart.  As to our own use of the chart,  we are not  relying on any of
those  conclusions  as the sole or even a  paramount  basis  for our view on Dr.
Shrotriya's compensation. The chart is merely one of many illustrative pieces of
the mosaic that depicts our overall concerns.

Receiving no response,  we wrote a letter to the Board on May 5, 2005,  in which
we  demanded  that  litigation  be  commenced   against  those  at  the  Company
responsible for what we saw as a giveaway of excess compensation. To justify our
request, we stated in part:

          I had received  assurances in response to my April 26 letter
          that the Compensation Committee was acting independently and
          took my points very seriously.  .... Thus, I was shocked and
          disgusted  to see in your proxy  filed at the end of the day
          last  Friday  that  Dr.  Shrotriya's   salary  remained   at
          $500,000,  that he received a $250,000 cash bonus,  and that
          he  received  not one but two  stock  option  grants  for an
          aggregate of 950,000 shares. Combined with prior grants, the
          compensation  committee has given away options for about 10%
          of the  outstanding  stock of  the Company to Dr. Shrotriya,
          while  the  shareholders  continue  to lose  money.  What is
          especially galling is that the option exercise prices ($6.66
          and $6.05) are  significantly  less than the price  recently
          paid by investors  ($7.75 per share) who put money  directly
          into the Company in the last financing. ....





          Your proxy claims that a  compensation  consultant was hired
          to provide the  Compensation  Committee  with  guidance with
          respect to executive compensation.  ... As you know, my firm
          invests exclusively in companies in your space.  Accordingly
          I am  very  surprised  that  a  reputable  consultant  could
          recommend  the levels of salary,  bonus and options  granted
          this year in light of the size of the Company as well as its
          substandard stock price performance. ....

          In light of the paucity of information  in the  Compensation
          Committee report, I have attempted to speak to the board. To
          date I have  been  rebuffed.  I feel  that I, and all of the
          shareholders  of the  Company,  are  entitled  to more of an
          explanation than we received in the proxy statement.

          Based on the results reached by the  compensation  committee
          we do not believe that they have acted  independently and in
          accordance with law when evaluating  executive  compensation
          this year,  nor do we believe that they have  fulfilled  the
          role of acting as a fiduciary for the shareholders.  We also
          do not believe that the negotiation  for, nor the acceptance
          of, this bounty by the Chief Executive Officer is consistent
          with his fiduciary duties to the shareholders.


Having received no meaningful response to our  correspondence,  a representative
of our firm spoke with the  Chairman on May 16 and  requested  a board seat.  We
felt that by granting our request (as the Company's second largest  shareholder)
the Board would have the  opportunity  to show that it was not  concerned  about
having a truly independent voice in the boardroom.

As  we  awaited  a  meaningful   response  to  our  concerns   about   executive
compensation,  we were also led to raise other  concerns  about the oversight of
the Company with the Board. For instance the Company's generics strategy strikes
us as  unfocused  and  ill-advised.  We believe  it is harming  the value of the
Company's  shares.  In  addition,  we  believe  that  the CEO has  little  or no
experience  in this very  competitive  segment of the  industry,  and we further
believe  that he should  remain  focused in areas in which his team is  skilled,
such as drug  development.  Along these lines, we question  recent  purchases of
non-core  assets at a time when the stock  price is falling and there has been a
lack of monetization of the Company's existing asset base.

Last night our counsel  finally  received a  responsive  letter from  Spectrum's
counsel.  As to our  request  that we be  granted a board  seat as a showing  of
openness in corporate  governance,  we were told that no decision had been made,
and our request was  deferred  until the Board's next  meeting.  As to our other
concerns,  we were informed that an Investigative  Committee of the Board (whose
members  were not  identified  in the letter)  had been  formed to consider  the
matters we raised,  and that the Committee had  unanimously  determined that our
demands were rejected. We of course will now consult with counsel about pursuing
those claims in another manner.





As a result of this lack of action in response to our communications,  we intend
to vote against the Board's slate of directors at next week's board meeting.  We
know that this cannot  influence the result of the vote as we are not nominating
an opposing slate and the Board is running  unopposed.  (We note that we had not
even  received a proxy  from the  Company  and had to call the  Company to get a
proxy faxed to us.)

However,  we hope to send a message to the Board that we are concerned about its
performance and that it is being watched. We believe that other shareholders are
similarly  dissatisfied.  For our part, we will continue to investigate  matters
which we believe indicate poor governance and control procedures and continue to
make  our  opinions  known  when we do not  believe  that the  current  board is
pursuing  policies  that  enhance  shareholder  value.  We hope  that  this will
encourage  the Board to fulfill its role as a watchdog for the  shareholders  of
the Company and to act as a check on  management's  future  activities.  We also
encourage our fellow  shareholders  to share with  Spectrum's  Board directly or
with us their  opinions on the  propriety of recent  actions the Board has taken
and any future actions they may question.  We believe that an active shareholder
base is one of the more  effective  ways to insure  that  boards  act to fulfill
their fiduciary duties.



                                                 /s/ Mitchell D. Kaye
                                                 -------------------------------
                                                 By: Mitchell D. Kaye
                                                 Title: Chief Investment Officer









                                                             Compensation
                                                                  For
                                                                 2004

------------------------------------------------------------------------------------------------------------------------------------
      Company              Name          Position       Salary      Bonus      Options     Total       Shares          Percentage of
                                                                                           Options     Outstanding       Options
                                                                                                                        (rounded)
------------------------------------------------------------------------------------------------------------------------------------

                                                                                                     
Spectrum              Rajesh         Chairman, Chief    $500,000   $250,000    450,000    1,071,600   15,352,949            7% 
Pharmaceuticals,      Shrotriya      Executive                                                        shares of 
Inc.                                 Officer,                                                         common stock 
                                     President                                                        outstanding as
                                                                                                      of 04/18/05
------------------------------------------------------------------------------------------------------------------------------------
Allos Therapeutics    Michael E.     President and      $351,346   $ 80,000     80,000      895,250   31,175,783 shares     3%
Inc.                  Hart           Chief Executive                                                  of common stock 
                                     Officer                                                          outstanding as of
                                                                                                      3/30/05
------------------------------------------------------------------------------------------------------------------------------------
AVI Biopharma, Inc.   Denis R.       Chief Executive    $330,000   $120,000          0      845,824   44,144,462 shares     2%
                      Burger, Ph.D.  Officer                                                          of common stock 
                                                                                                      outstanding as of
                                                                                                      3/18/05
------------------------------------------------------------------------------------------------------------------------------------
Avigen Inc.           Kenneth G.                        $343,775   $ 25,000    125,000      492,500   20,381,250 shares     2%
                      Chahine,                                                                        of common stock 
                      Ph.D., J.D.                                                                     outstanding as of
                                                                                                      04/06/05
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Cortex                Roger G.       President, Chief   $138,000   $ 63,000    300,000    1,267,195   32,753,122 shares     4%
Pharmaceuticals       Stoll, Ph.D.   Executive                                                        of common stock 
Inc.                                 Officer                                                          outstanding as of
                                                                                                      03/15/05
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Genta Inc.            Raymond P.     Chairman and       $420,000   $160,000     75,000    6,738,262   95,358,215 shares     7%
                      Warrell, Jr.,  Chief Executive                                                  of common stock 
                      M.D.           Officer                                                          outstanding as of
                                                                                                      03/31/05
------------------------------------------------------------------------------------------------------------------------------------
Immunomedics Inc.     Cynthia L.     President and      $500,000   $125,000    150,000    1,020,000   54,073,059 shares     2%
                      Sullivan       Chief Executive                                                  of common stock 
                                     Officer                                                          outstanding as of
                                                                                                      10/13/04
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Kosan Biosciences     Daniel V.      Chairman, Chief    $400,000   $105,000    105,000      570,000   29,189,310 shares     2%
Inc.                  Santi, M.D.,   Executive                                                        of common stock 
                      Ph.D.          Officer and                                                      outstanding as of 
                                     Director                                                         04/01/05
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La Jolla              Steven B.      Chief Executive    $418,855   $144,474    300,000      250,000   73,758,850 shares     0.3%
Pharmaceutical Co.    Engle          Officer and                                                      of common stock 
                                     Chairman                                                         outstanding as of
                                                                                                      03/24/05
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Maxim                 Larry G.       President and      $450,000   $300,000    225,000    1,413,667   28,561,091 shares     5%
Pharmaceuticals       Stambaugh      Chief Executive                                                  of common stock 
Inc.                                 Officer                                                          outstanding as of
                                                                                                      12/31/04
------------------------------------------------------------------------------------------------------------------------------------
Neurobiological       Paul E.        President and       212,500    225,000                 760,000   26,444,487 shares     3%
Technologies Inc*     Frieman        Chief Executive                                                  of common stock 
                                     Officer                                                          and 534,000 of
                                                                                                      preferred stock as
                                                                                                      of 9/24/04
------------------------------------------------------------------------------------------------------------------------------------
Sangamo BioSciences   Edward O.      President and       394,000    170,000    200,000      600,000   23,377,071 shares     3%
Inc.                  Lanphioer II   Chief Executive                                                  of common stock 
                                     Officer                                                          as of 4/11/05
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Seattle Genetics      Clay B.        President and       358,333    180,000     50,000      930,000   42,175,928 shares     2%
Inc.                  Siegall,       Chief Executive                                                  of common stock and
                      Ph.D.          Officer                                                          15,000,000 shares
                                                                                                      of preferred stock
                                                                                                      as of 3/22/05
------------------------------------------------------------------------------------------------------------------------------------
SuperGen Inc.         Dr. James      President and       383,333    100,000  1,250,000    1,468,000   51,145,423 shares     3%
                      Manuso, Ph.D.  Chief Executive                                                  of common stock 
                                     Officer                                                          as of 3/24/05
------------------------------------------------------------------------------------------------------------------------------------
Targeted Genetics     H. Stewart     President and       398,000     81,969    200,000      992,344   85,628,244 shares     1%
Corp.                 Parker         Chief Executive                                                  of common stock 
                                     Officer                                                          as of 3/25/05
------------------------------------------------------------------------------------------------------------------------------------
Vical Inc.            Vijay B.       President and       380,000    200,000    417,000*     675,000   23,515,744 shares     3%
                      Samant         Chief Executive                           *includes              of common stock 
                                     Officer                                   317,500 of             and 15,000,000 
                                                                               restricted             shares of 
                                                                               stock                  preferred stock 
                                                                               awards                 as of 3/24/05
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----------------
* October, 2004 Proxy





Note: Chart does not include additional 500,000 option grant to Dr. Shrotriya on
January 3, 2005, which would bring his percentage of options to 10%.


Caution: Information in chart was taken from public filings of listed companies,
and was not  independently  verified.  Listed  companies are those identified by
Spectrum in its proxy statement  performance  graph as its peer group companies.
No representation is made as to the appropriateness of these companies and their
CEOs for a comparison of executive compensation.