Under the Securities Exchange Act of 1934
(Amendment No. 4)(1)

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

(Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. o

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits.  See §240.13d-7 for other parties to whom copies are to be sent.

(1) The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

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EXPLANATORY NOTE

This Amendment No. 4 to the Schedule 13D amends and supplements the Schedule 13D, filed July 18, 2014 and amended on January 16, 2015, February 5, 2015 and March 25, 2015 (the “Schedule 13D”), by the Filing Persons (as defined below) relating to the Common Stock, par value $0.0001 per share, of Minerva Neurosciences, Inc., a Delaware corporation (the “Issuer”).  The Issuer is filing this amendment to the Schedule 13D solely to update the disclosures set forth therein to include the open market transactions discussed in Item 3 below.

Item 3.                     Source and Amount of Funds or Other Consideration

Item 3 is hereby amended to add the following:

During the period from March 25, 2015 through March 24, 2016, Care Capital Investments III L.P. sold 101,186 shares of Issuer’s Common Stock and Care Capital Offshore Investments III LP sold 1,690 shares of Issuer’s Common Stock in open market transactions.

Item 5.                     Interest in Securities of the Issuer

Item 5 is hereby amended and restated as follows:

(a)                                 As of March 30, 2016, Care Capital Investments III L.P. is the beneficial owner of 1,534,098 shares of the Issuer’s Common Stock, representing 5.5% of the Issuer’s shares of Common Stock outstanding (based upon 27,760,657 shares of Common Stock outstanding, as reported in the Issuer’s Annual Report on Form 10-K for the year ended December 31, 2015 filed on March 14, 2016).  As of March 30, 2016, Care Capital Offshore Investments III LP is the beneficial owner of 25,618 shares of the Issuer’s Common Stock, representing 0.1% of the Issuer’s shares of Common Stock outstanding (based upon 27,760,657 shares of Common Stock outstanding, as reported in the Issuer’s Annual Report on Form 10-K for the year ended December 31, 2015 filed on March 14, 2016).  By virtue of Care Capital III LLC’s status as general partner of Care Capital Investments III L.P. and Care Capital Offshore Investments III LP , Care Capital III LLC may be deemed the beneficial owner of 1,559,716 shares of the Issuer’s Common Stock held by Care Capital Investments III L.P. and Care Capital Offshore Investments III LP , representing 5.6% of the Issuer’s shares of Common Stock outstanding (based upon 27,760,657 shares of Common Stock outstanding, as reported in the Issuer’s Annual Report on Form 10-K for the year ended December 31, 2015 filed on March 14, 2016).  Care Capital III LLC disclaims beneficial ownership of the securities, and this report shall not be deemed an admission that Care Capital III LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their pecuniary interest therein.

(b)                                 By virtue of its status as general partner of Care Capital Investments III L.P. and Care Capital Offshore Investments III LP, Care Capital III LLC may be deemed to share voting and dispositive power with respect to the 1,534,098 shares of Issuer’s Common Stock held by Care Capital Investments III L.P. and 25,618 shares of Issuer’s Common Stock held by Care Capital Offshore Investments III LP.  Care Capital III LLC disclaims

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beneficial ownership of the securities and this report shall not be deemed an admission that Care Capital III LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their pecuniary interest therein.

(c)                                  During the past sixty days prior to the date hereof, the following transactions occurred:

(d)                                 No person, other than Care Capital III LLC, is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by each of Care Capital Investments III L.P. and Care Capital Offshore Investments III LP.

(e)                                  Not applicable.

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SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

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